Nucleophilic substitutions in the isoindole series as a valuable tool to synthesize derivatives with antitumor activity

Tetrahedron

Volumn 67, Issue 11, 2011, Pages 2072-2080

  Diana, Patrizia ^a   Martorana, Annamaria ^a   Barraja, Paola ^a   Montalbano, Alessandra ^a   Carbone, Anna ^a   Cirrincione, Girolamo ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Antitumor activity; Colchicine analogues; Docking; Isoindoles; Nucleophilic substitutions

Indexed keywords

1 ACETYL 3 [(4 METHOXYPHENYL)SULFANYL] 2H ISOINDOLE; 1 CARBOXALDEHYDE 3 [(4 METHOXYPHENYL)SULFANYL] 2H ISOINDOLE; CARBON; ISOINDOLE DERIVATIVE; NITROGEN; NUCLEOPHILE; OXYGEN; SULFUR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL COUNT; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; GEOGRAPHIC INFORMATION SYSTEM; HUMAN; HUMAN CELL; NUCLEOPHILICITY; PRIORITY JOURNAL;

EID: 79952038223     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2011.01.056     Document Type: Article

References (22)

1. R. Bonnett, and S.A. North A.R. Katritzky, A.J. Boulton, Advances in Heterocycles Chemistry Vol. 29 1981 341 399
2. F.S. Babichev, V.A. Kovtunenko, and A.K. Tyltin Russ. Chem. Rev. 50 1981 1087 1103
3. O.V. Hordiyenko, I.V. Rudenko, A.V. Biitseva, A.V. Turov, A. Arrault, N. Brosse, O. Fabre, B. Jamart-Grgoire, R.I. Zubatyuk, and O.V. Shishkin Tetrahedron 65 2009 6218 6225
4. G. Cirrincione, A.M. Almerico, A. Passannanti, P. Diana, and F. Mingoia Synthesis 1997 1169 1173
5. P. Barraja, P. Diana, A. Carbone, and G. Cirrincione Tetrahedron 64 2008 11625 11631
6. P. Barraja, V. Span, P. Diana, A. Carbone, G. Cirrincione, D. Vedaldi, A. Salvador, G. Viola, and F. Dall'Acqua Bioorg. Med. Chem. Lett. 19 2009 1711 1714
7. P. Barraja, V. Span, P. Diana, A. Carbone, and G. Cirrincione Tetrahedron Lett. 50 2009 5389 5391
8. Allison, B.; Rabinowitz, M.H. Patent WO 2008124518, 2008;
9. Chem. Abstr. 149 2008 448404
10. Cirrincione, G.; Diana, P. WO 2008041264, 2008;
11. Chem. Abstr. 148 2008 426916
12. Cheng, Y.; Tomaszewski, M.; Yang, H. WO 2007139464, 2007;
13. Chem. Abstr. 148 2007 54892
14. P. Diana, A. Martorana, P. Barraja, A. Montalbano, G. Dattolo, G. Cirrincione, F. Dall'Acqua, A. Salvador, D. Vedaldi, G. Basso, and G. Viola J. Med. Chem. 51 2008 2387 2399
15. G. La Regina, M.C. Edler, A. Brancale, S. Kandil, A. Colluccia, F. Piscitelli, E. Hamel, G. De Martino, R. Matesanz, J.F. Diaz, A.I. Scovassi, E. Prosperi, A. Lavecchia, E. Novellino, M. Artico, and R. Silvestri J. Med. Chem. 50 2007 2865 2874
16. H. von Dobeneck, H. Reinhard, H. Dueubel, and D. Wolkenstein Chem. Ber. 102 1969 1357 1362
17. A. Nagle, W. Hur, and N.S. Gray Curr. Drug Targets 7 2006 305 326
18. E. Pasquier, N. Andr, and D. Braguer Curr. Cancer Drug Targets 7 2007 566 581
19. G.R. Pettit, S.G. Singh, M.R. Boyd, E. Hamel, R.K. Pettit, J.M. Schmidt, and F. Hogan J. Med. Chem. 38 1995 1666 1672
20. M.A. Jordan, and L. Wilson Nat. Rev. Cancer 4 2004 253 265
21. R.B. Ravelli, B. Gigant, P.A. Curmi, I. Jourdan, S. Lachkar, A. Sobel, and M. Knossow Nature 428 2004 198 202
22. 15 GLIDE Version 4.5, Prime, Version 1.6 2007 Schrödinger LLC New York, NY