Pyrrolo[2,3-h]quinolinones: A new ring system with potent photoantiproliferative activity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 24, 2006, Pages 8712-8728

  Barraja, Paola ^a   Diana, Patrizia ^a   Montalbano, Alessandra ^a   Dattolo, Gaetano ^a   Cirrincione, Girolamo ^a   Viola, Giampietro ^b   Vedaldi, Daniela ^b   Dall'Acqua, Francesco ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Angelicin; Antitumour activity; Photochemotherapy; Pyrroloquinolinones

Indexed keywords

3 BENZOYL 7 BENZYL 1,5,6,7 TETRAHYDRO 2H PYRROLO[2,3 H]QUINOLIN 2 ONE; 3 BENZOYL 7,8 DIMETHYL 1,5,6,7 TETRAHYDRO 2H PYRROLO[2,3 H]QUINOLIN 2 ONE; 3 CYANO 8 METHYL 7 PHENYL 1,5,6,7 TETRAHYDRO 2H PYRROLO[2,3 H]QUINOLIN 2 ONE; 3 ETHOXYCARBONYL 8 METHYL 7 PHENYL 1,5,6,7 TETRAHYDRO 2H PYRROLO[2,3 H]QUINOLIN 2 ONE; 4,8 DIMETHYL 1,7 DIHYDRO 2H PYRROLO[2,3 H]QUINOLIN 2 ONE; 7 BENZYL 8 METHYL 3 PHENYLSULFONYL 1,5,6,7 TETRAHYDRO 2H PYRROLO[2,3 H]QUINOLIN 2 ONE; 7,8 DIMETHYL 3 PHENYLSULFONYL 1,5,6,7 TETRAHYDRO 2H PYRROLO[2,3 H]QUINOLIN 2 ONE; 8 METHYL 7 PHENYL 3 BENZOYL 1,5,6,7 TETRAHYDRO 2H PYRROLO[2,3 H]QUINOLIN 2 ONE; 8 METHYL 7 PHENYL 3 PHENYLSULFONYL 1,5,6,7 TETRAHYDRO 2H PYRROLO[2,3 H]QUINOLIN 2 ONE; ANGELICIN; ANTINEOPLASTIC AGENT; METHOXSALEN; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DNA DAMAGE; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG SYNTHESIS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC 50; LIPID PEROXIDATION; LYSOSOME; MITOCHONDRION; PHOTODEGRADATION; PHOTOTOXICITY; PHYSICAL CHEMISTRY; RADIATION DOSE; ULTRAVIOLET A RADIATION;

ACRIDINE ORANGE; ADENOCARCINOMA; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-LINKING REAGENTS; DNA; DNA DAMAGE; ERYTHROCYTE MEMBRANE; FIBROSARCOMA; FLUORESCENT DYES; HL-60 CELLS; HUMANS; INTERCALATING AGENTS; LIPID PEROXIDATION; LYSOSOMES; MASS SPECTROMETRY; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROTEINS; QUINOLONES; RHODAMINES; ULTRAVIOLET RAYS;

EID: 33750526864     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.061     Document Type: Article

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