Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I

Journal of Medicinal Chemistry

Volumn 51, Issue 8, 2008, Pages 2387-2399

  Diana, Patrizia ^a   Martorana, Annamaria ^a   Barraja, Paola ^a   Montalbano, Alessandra ^a   Dattolo, Gactano ^a   Cirrincione, Girolamo ^a   Dall'Acqua, Francesco ^b   Salvador, Alessia ^b   Vedaldi, Daniela ^b   Basso, Giuseppe ^b   Viola, Giampietro ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

11 CYANO 2,3 DICHLOROISOINDOLO[2,1 A]QUINOXALINE; 11 CYANO 2,3 DIMETHYLISOINDOLO[2,1 A]QUINOXALINE; 11 CYANO 3 METHOXYISOINDOLO[2,1 A]QUINOXALINE; 11 CYANOISOINDOLO[2,1 A]QUINOXALINE; 2,3 DICHLORO 5H ISOINDOLO[2,1 A]QUINOXALIN 6 ONE; 2,3 DIMETHYL 5H ISOINDOLO[2,1 A]QUINOXALIN 6 ONE; 3 METHOXY 5H ISOINDOLO[2,1 A]QUINOXALIN 6 ONE; 4 METHYL 5H ISOINDOLO[2,1 A]QUINOXALIN 6 ONE; 5H ISOINDOLO[2,1 A]QUINOXALIN 6 ONE; DNA TOPOISOMERASE; QUINOXALINE DERIVATIVE; TUBULIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; DEPOLARIZATION; DRUG INHIBITION; DRUG SCREENING; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MITOSIS INDEX; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, FLUORESCENCE; MITOSIS; POLYMERS; QUINOXALINES; REACTIVE OXYGEN SPECIES; SPECTROPHOTOMETRY, INFRARED; TUBULIN;

EID: 43049130352     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070834t     Document Type: Article

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