Synthesis and biological evaluation of 1-(6-methylpyridin-2-yl)-5- (quinoxalin-6-yl)-1,2,3-triazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 4, 2013, Pages 1083-1086

  Li, Fei ^a   Park, Yunjeong ^a   Hah, Jung Mi ^b   Ryu, Jae Sang ^a  

^a Ewha Womans University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

1,2,3 Triazole; ALK5; Anticancer; Click chemistry; TGF type 1 receptor kinase

Indexed keywords

1 (6 METHYLPYRIDIN 2 YL) 5 (QUINOXALIN 6 YL) 1,2,3 TRIAZOLE DERIVATIVE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COPPER; MITOGEN ACTIVATED PROTEIN KINASE 14; PALLADIUM; STAUROSPORINE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; CATALYSIS; CYCLOADDITION; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50;

CLICK CHEMISTRY; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84872939277     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.12.008     Document Type: Article

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