Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity

European Journal of Medicinal Chemistry

Volumn 74, Issue , 2014, Pages 340-357

  Spanò, Virginia ^a   Montalbano, Alessandra ^a   Carbone, Anna ^a   Parrino, Barbara ^a   Diana, Patrizia ^a   Cirrincione, Girolamo ^a   Castagliuolo, Ignazio ^b   Brun, Paola ^b   Issinger, Olaf Georg ^c   Tisi, Silvia ^b   Primac, Irina ^b   Vedaldi, Daniela ^b   Salvador, Alessia ^b   Barraja, Paola ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Antimitotic activity; Antiproliferative activity; Pyrrolo 3,4 h quinazolines; Tubulin polymerization; Vascular disrupting activity

Indexed keywords

MATRIGEL; PYRROLO[3,4 H]QUINAZOLINE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMITOTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL MEDIATED CYTOTOXICITY; CELL MIGRATION; DRUG ACTIVITY; DRUG SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE ASSEMBLY; TUMOR CELL LINE;

ANTIMITOTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; PYRROLO[3,4-H]QUINAZOLINES; TUBULIN POLYMERIZATION; VASCULAR DISRUPTING ACTIVITY;

CELL DEATH; CELL LINE, TUMOR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LYSOSOMES; MITOCHONDRIA; MITOSIS; PYRROLES; QUINAZOLINES;

EID: 84893428486     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.014     Document Type: Article

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