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Volumn 45, Issue 2, 2015, Pages 101-109

Biology of hypoxia

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ADENOSINE PHOSPHATE; HYPOXIA INDUCIBLE FACTOR 1; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; MICRORNA; NITROIMIDAZOLE DERIVATIVE; OXYGEN; PIMONIDAZOLE; PROTEIN KINASE B; PROTEIN P53;

EID: 84924058436     PISSN: 00012998     EISSN: 15584623     Source Type: Journal    
DOI: 10.1053/j.semnuclmed.2014.10.002     Document Type: Review
Times cited : (129)

References (96)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: The next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0034114513 scopus 로고    scopus 로고
    • Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line
    • J. Bussink, J.H. Kaanders, and P.F. Rijken Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line Radiat Res 153 2000 398 404
    • (2000) Radiat Res , vol.153 , pp. 398-404
    • Bussink, J.1    Kaanders, J.H.2    Rijken, P.F.3
  • 4
    • 84876993950 scopus 로고    scopus 로고
    • Normalizing tumor microenvironment to treat cancer: Bench to bedside to biomarkers
    • R.K. Jain Normalizing tumor microenvironment to treat cancer: Bench to bedside to biomarkers J Clin Oncol 31 2013 2205 2218
    • (2013) J Clin Oncol , vol.31 , pp. 2205-2218
    • Jain, R.K.1
  • 5
    • 84884566959 scopus 로고    scopus 로고
    • The irradiated tumor microenvironment: Role of tumor-associated macrophages in vascular recovery
    • J.S. Russell, and J.M. Brown The irradiated tumor microenvironment: Role of tumor-associated macrophages in vascular recovery Front Physiol 4 2013 157
    • (2013) Front Physiol , vol.4 , pp. 157
    • Russell, J.S.1    Brown, J.M.2
  • 6
    • 84867514301 scopus 로고    scopus 로고
    • Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy
    • T.W. Meijer, J.H. Kaanders, and P.N. Span Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy Clin Cancer Res 18 2012 5585 5594
    • (2012) Clin Cancer Res , vol.18 , pp. 5585-5594
    • Meijer, T.W.1    Kaanders, J.H.2    Span, P.N.3
  • 7
    • 84924043110 scopus 로고    scopus 로고
    • Glossary terms in radiation biology
    • 4th ed (pp 356). Taylor & Francis Abingdon, Oxon
    • A.J. van der Kogel, and M. Joiner Glossary terms in radiation biology Basic Clinical Radiobiology 4th ed (pp 356). 2009 Taylor & Francis Abingdon, Oxon
    • (2009) Basic Clinical Radiobiology
    • Van Der Kogel, A.J.1    Joiner, M.2
  • 8
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • M. Höckel, and P. Vaupel Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects J Natl Cancer Inst 93 2001 266 276
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Höckel, M.1    Vaupel, P.2
  • 10
    • 0040091483 scopus 로고
    • Ueber Desensibilisierung gegen Roentgen - Und Radiumstrahlen
    • G. Schwarz Ueber Desensibilisierung gegen Roentgen - Und Radiumstrahlen Muenchner Med Wochenschr 56 1909 1217 1218
    • (1909) Muenchner Med Wochenschr , vol.56 , pp. 1217-1218
    • Schwarz, G.1
  • 11
    • 0000912662 scopus 로고
    • Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
    • A.G. Ide, N.H. Baker, and S.L. Warren Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber Am J Roentgenol 42 1939 891 899
    • (1939) Am J Roentgenol , vol.42 , pp. 891-899
    • Ide, A.G.1    Baker, N.H.2    Warren, S.L.3
  • 12
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
    • G.H. Algire, H.W. Chalkley, and F.Y. Legallais Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants J Natl Cancer Inst 6 1945 73 85
    • (1945) J Natl Cancer Inst , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2    Legallais, F.Y.3
  • 13
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • J. Folkman Tumor angiogenesis: Therapeutic implications N Engl J Med 285 1971 1182 1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 14
    • 60549104814 scopus 로고    scopus 로고
    • Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model
    • E.M. Hendriksen, P.N. Span, and J. Schuuring Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model Microvasc Res 77 2009 96 103
    • (2009) Microvasc Res , vol.77 , pp. 96-103
    • Hendriksen, E.M.1    Span, P.N.2    Schuuring, J.3
  • 15
    • 0032952966 scopus 로고    scopus 로고
    • Evidence for characteristic vascular patterns in solid tumours: Quantitative studies using corrosion casts
    • M.A. Konerding, W. Malkusch, and B. Klapthor Evidence for characteristic vascular patterns in solid tumours: Quantitative studies using corrosion casts Br J Cancer 80 1999 724 732
    • (1999) Br J Cancer , vol.80 , pp. 724-732
    • Konerding, M.A.1    Malkusch, W.2    Klapthor, B.3
  • 16
    • 0028958059 scopus 로고
    • Vascularity and perfusion of human gliomas xenografted in the athymic nude mouse
    • H.J. Bernsen, P.F. Rijken, and T. Oostendorp Vascularity and perfusion of human gliomas xenografted in the athymic nude mouse Br J Cancer 71 1995 721 726
    • (1995) Br J Cancer , vol.71 , pp. 721-726
    • Bernsen, H.J.1    Rijken, P.F.2    Oostendorp, T.3
  • 17
    • 84906080054 scopus 로고    scopus 로고
    • Hypoxia, metabolism, and growth factor signaling in head and neck squamous cell carcinoma: Correlation between primary and xenograft tumors
    • H. Stegeman, S.E. Rademakers, and P.N. Span Hypoxia, metabolism, and growth factor signaling in head and neck squamous cell carcinoma: Correlation between primary and xenograft tumors Head Neck 36 2014 1288 1295
    • (2014) Head Neck , vol.36 , pp. 1288-1295
    • Stegeman, H.1    Rademakers, S.E.2    Span, P.N.3
  • 18
    • 0029035872 scopus 로고
    • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors
    • T.W. Secomb, R. Hsu, and E.T. Ong Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors Acta Oncol 34 1995 313 316
    • (1995) Acta Oncol , vol.34 , pp. 313-316
    • Secomb, T.W.1    Hsu, R.2    Ong, E.T.3
  • 19
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • R.H. Thomlinson, and L.H. Gray The histological structure of some human lung cancers and the possible implications for radiotherapy Br J Cancer 9 1955 539 549
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 20
    • 0033000313 scopus 로고    scopus 로고
    • 2 gradients in window chamber tumours: Impact on tumour hypoxia
    • 2 gradients in window chamber tumours: Impact on tumour hypoxia Br J Cancer 79 1999 1717 1722
    • (1999) Br J Cancer , vol.79 , pp. 1717-1722
    • Dewhirst, M.W.1    Ong, E.T.2    Braun, R.D.3
  • 21
    • 0018760476 scopus 로고
    • Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
    • J.M. Brown Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation Br J Radiol 52 1979 650 656
    • (1979) Br J Radiol , vol.52 , pp. 650-656
    • Brown, J.M.1
  • 22
    • 84862659615 scopus 로고    scopus 로고
    • 2 fluctuation pattern and cycling hypoxia in human cervical carcinoma and melanoma xenografts
    • 2 fluctuation pattern and cycling hypoxia in human cervical carcinoma and melanoma xenografts Int J Radiat Oncol Biol Phys 83 2012 1317 1323
    • (2012) Int J Radiat Oncol Biol Phys , vol.83 , pp. 1317-1323
    • Ellingsen, C.1    Ovrebø, K.M.2    Galappathi, K.3
  • 23
    • 84898542253 scopus 로고    scopus 로고
    • Hypoxia in tumors: Pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinical implications
    • P. Vaupel, and A. Mayer Hypoxia in tumors: Pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinical implications Adv Exp Med Biol 812 2014 19 24
    • (2014) Adv Exp Med Biol , vol.812 , pp. 19-24
    • Vaupel, P.1    Mayer, A.2
  • 25
    • 33846850493 scopus 로고    scopus 로고
    • Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers
    • A.S. Ljungkvist, J. Bussink, and J.H. Kaanders Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers Radiat Res 167 2007 127 145
    • (2007) Radiat Res , vol.167 , pp. 127-145
    • Ljungkvist, A.S.1    Bussink, J.2    Kaanders, J.H.3
  • 27
    • 0034307206 scopus 로고    scopus 로고
    • Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescense based fiber-optic probes
    • J. Bussink, J.H. Kaanders, and A.M. Strik Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescense based fiber-optic probes Radiother Oncol 57 2000 21 30
    • (2000) Radiother Oncol , vol.57 , pp. 21-30
    • Bussink, J.1    Kaanders, J.H.2    Strik, A.M.3
  • 28
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • M. Nordsmark, M. Overgaard, and J. Overgaard Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck Radiother Oncol 41 1996 31 39
    • (1996) Radiother Oncol , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 30
    • 4644283094 scopus 로고    scopus 로고
    • Assessment of tumor oxygenation by electron paramagnetic resonance: Principles and applications
    • B. Gallez, C. Baudelet, and B.F. Jordan Assessment of tumor oxygenation by electron paramagnetic resonance: Principles and applications NMR Biomed 17 2004 240 262
    • (2004) NMR Biomed , vol.17 , pp. 240-262
    • Gallez, B.1    Baudelet, C.2    Jordan, B.F.3
  • 31
    • 0029033810 scopus 로고
    • Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation
    • F. Goda, J.A. OHara, and E.S. Rhodes Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation Cancer Res 55 1995 2249 2252
    • (1995) Cancer Res , vol.55 , pp. 2249-2252
    • Goda, F.1    Ohara, J.A.2    Rhodes, E.S.3
  • 33
    • 0026542912 scopus 로고
    • 19F magnetic resonance spectroscopy and immunohistochemistry
    • 19F magnetic resonance spectroscopy and immunohistochemistry Radiat Res 129 1992 71 78
    • (1992) Radiat Res , vol.129 , pp. 71-78
    • Kwock, L.1    Gill, M.2    McMurry, H.L.3
  • 34
    • 0028224408 scopus 로고
    • Non-invasive determination of tumor oxygen tension and local variation with growth
    • R.P. Mason, P.P. Antich, and E.E. Babcock Non-invasive determination of tumor oxygen tension and local variation with growth Int J Radiat Oncol Biol Phys 29 1994 95 103
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 95-103
    • Mason, R.P.1    Antich, P.P.2    Babcock, E.E.3
  • 35
    • 0034038284 scopus 로고    scopus 로고
    • Effects of nicotinamide and carbogen on tumour oxygenation, blood flow, energetics and blood glucose levels
    • S.P. Robinson, F.A. Howe, and M. Stubbs Effects of nicotinamide and carbogen on tumour oxygenation, blood flow, energetics and blood glucose levels Br J Cancer 82 2000 2007 2014
    • (2000) Br J Cancer , vol.82 , pp. 2007-2014
    • Robinson, S.P.1    Howe, F.A.2    Stubbs, M.3
  • 36
    • 35448972596 scopus 로고    scopus 로고
    • Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome
    • S.M. Evans, K.L. Du, and A.A. Chalian Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome Int J Radiat Oncol Biol Phys 69 2007 1024 1031
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , pp. 1024-1031
    • Evans, S.M.1    Du, K.L.2    Chalian, A.A.3
  • 37
    • 84864003904 scopus 로고    scopus 로고
    • Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: Results of a phase III randomized trial
    • G.O. Janssens, S.E. Rademakers, and C.H. Terhaard Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: Results of a phase III randomized trial J Clin Oncol 30 2012 1777 1783
    • (2012) J Clin Oncol , vol.30 , pp. 1777-1783
    • Janssens, G.O.1    Rademakers, S.E.2    Terhaard, C.H.3
  • 38
    • 0028785458 scopus 로고
    • Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver
    • G.E. Arteel, R.G. Thurman, and J.M. Yates Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver Br J Cancer 72 1995 889 895
    • (1995) Br J Cancer , vol.72 , pp. 889-895
    • Arteel, G.E.1    Thurman, R.G.2    Yates, J.M.3
  • 39
    • 0029012868 scopus 로고
    • Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids
    • M.W. Gross, U. Karbach, and K. Groebe Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids Int J Cancer 61 1995 567 573
    • (1995) Int J Cancer , vol.61 , pp. 567-573
    • Gross, M.W.1    Karbach, U.2    Groebe, K.3
  • 40
    • 0025354544 scopus 로고
    • Intermittent blood flow in the KHT sarcoma - Flow cytometry studies using Hoechst 33342
    • A.I. Minchinton, R.E. Durand, and D.J. Chaplin Intermittent blood flow in the KHT sarcoma - Flow cytometry studies using Hoechst 33342 Br J Cancer 62 1990 195 200
    • (1990) Br J Cancer , vol.62 , pp. 195-200
    • Minchinton, A.I.1    Durand, R.E.2    Chaplin, D.J.3
  • 41
    • 0032944785 scopus 로고    scopus 로고
    • Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: Effects of carbogen and nicotinamide
    • J. Bussink, J.H. Kaanders, and P.F. Rijken Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: Effects of carbogen and nicotinamide Radiother Oncol 50 1999 173 184
    • (1999) Radiother Oncol , vol.50 , pp. 173-184
    • Bussink, J.1    Kaanders, J.H.2    Rijken, P.F.3
  • 42
    • 52449099235 scopus 로고    scopus 로고
    • 18F]FMISO autoradiography and pimonidazole immunohistochemistry in human head and neck carcinoma xenografts
    • 18F]FMISO autoradiography and pimonidazole immunohistochemistry in human head and neck carcinoma xenografts Eur J Nucl Med Mol Imaging 35 2008 1803 1811
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , pp. 1803-1811
    • Troost, E.G.1    Laverman, P.2    Philippens, M.E.3
  • 43
    • 33748185692 scopus 로고    scopus 로고
    • 18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors
    • 18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors Radiother Oncol 80 2006 157 164
    • (2006) Radiother Oncol , vol.80 , pp. 157-164
    • Troost, E.G.1    Laverman, P.2    Kaanders, J.H.3
  • 44
    • 84887334596 scopus 로고    scopus 로고
    • 18F-FDG PET early response evaluation of locally advanced non-small cell lung cancer treated with concomitant chemoradiotherapy
    • 18F-FDG PET early response evaluation of locally advanced non-small cell lung cancer treated with concomitant chemoradiotherapy J Nucl Med 54 2013 1528 1534
    • (2013) J Nucl Med , vol.54 , pp. 1528-1534
    • Usmanij, E.A.1    De Geus-Oei, L.F.2    Troost, E.G.3
  • 45
    • 77954029167 scopus 로고    scopus 로고
    • PET-CT for response assessment and treatment adaptation in head and neck cancer
    • J. Bussink, C.M. van Herpen, and J.H. Kaanders PET-CT for response assessment and treatment adaptation in head and neck cancer Lancet Oncol 11 2010 661 669
    • (2010) Lancet Oncol , vol.11 , pp. 661-669
    • Bussink, J.1    Van Herpen, C.M.2    Kaanders, J.H.3
  • 46
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • G.L. Semenza Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics Oncogene 29 2010 625 634
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 47
    • 60549083256 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    • G.L. Semenza Regulation of cancer cell metabolism by hypoxia-inducible factor 1 Semin Cancer Biol 19 2009 12 16
    • (2009) Semin Cancer Biol , vol.19 , pp. 12-16
    • Semenza, G.L.1
  • 48
    • 46749121459 scopus 로고    scopus 로고
    • Causes and consequences of increased glucose metabolism of cancers
    • R.J. Gillies, I. Robey, and R.A. Gatenby Causes and consequences of increased glucose metabolism of cancers J Nucl Med 49 2008 24S 42S
    • (2008) J Nucl Med , vol.49 , pp. 24S-42S
    • Gillies, R.J.1    Robey, I.2    Gatenby, R.A.3
  • 49
    • 34249982595 scopus 로고    scopus 로고
    • YC-1 inhibits HIF-1 expression in prostate cancer cells: Contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia
    • H.L. Sun, Y.N. Liu, and Y.T. Huang YC-1 inhibits HIF-1 expression in prostate cancer cells: Contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia Oncogene 26 2007 3941 3951
    • (2007) Oncogene , vol.26 , pp. 3941-3951
    • Sun, H.L.1    Liu, Y.N.2    Huang, Y.T.3
  • 50
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • M.W. Dewhirst, Y. Cao, and B. Moeller Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response Nat Rev Cancer 8 2008 425 437
    • (2008) Nat Rev Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 51
    • 0347594127 scopus 로고    scopus 로고
    • Vascular endothelial growth factor independently predicts the efficacy of postoperative radiotherapy in node-negative breast cancer patients
    • P. Manders, F.C. Sweep, and V.C. Tjan-Heijnen Vascular endothelial growth factor independently predicts the efficacy of postoperative radiotherapy in node-negative breast cancer patients Clin Cancer Res 9 2003 6363 6370
    • (2003) Clin Cancer Res , vol.9 , pp. 6363-6370
    • Manders, P.1    Sweep, F.C.2    Tjan-Heijnen, V.C.3
  • 52
    • 0043123069 scopus 로고    scopus 로고
    • Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: Association with treatment outcome
    • P.N. Span, J. Bussink, and P. Manders Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: Association with treatment outcome Br J Cancer 89 2003 271 276
    • (2003) Br J Cancer , vol.89 , pp. 271-276
    • Span, P.N.1    Bussink, J.2    Manders, P.3
  • 53
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • B.G. Wouters, and M. Koritzinsky Hypoxia signalling through mTOR and the unfolded protein response in cancer Nat Rev Cancer 8 2008 851 864
    • (2008) Nat Rev Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 54
    • 28844470269 scopus 로고    scopus 로고
    • The unfolded protein response: A novel component of the hypoxic stress response in tumors
    • D.E. Feldman, V. Chauhan, and A.C. Koong The unfolded protein response: A novel component of the hypoxic stress response in tumors Mol Cancer Res 3 2005 597 605
    • (2005) Mol Cancer Res , vol.3 , pp. 597-605
    • Feldman, D.E.1    Chauhan, V.2    Koong, A.C.3
  • 55
    • 33746886623 scopus 로고    scopus 로고
    • "translating" tumor hypoxia: Unfolded protein response (UPR)-dependent and UPR-independent pathways
    • C. Koumenis, and B.G. Wouters "Translating" tumor hypoxia: Unfolded protein response (UPR)-dependent and UPR-independent pathways Mol Cancer Res 4 2006 423 436
    • (2006) Mol Cancer Res , vol.4 , pp. 423-436
    • Koumenis, C.1    Wouters, B.G.2
  • 56
    • 0036837864 scopus 로고    scopus 로고
    • Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha
    • C. Koumenis, C. Naczki, and M. Koritzinsky Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha Mol Cell Biol 22 2002 7405 7416
    • (2002) Mol Cell Biol , vol.22 , pp. 7405-7416
    • Koumenis, C.1    Naczki, C.2    Koritzinsky, M.3
  • 57
    • 4344648874 scopus 로고    scopus 로고
    • Activating transcription factor 4 is translationally regulated by hypoxic stress
    • J.D. Blais, V. Filipenko, and M. Bi Activating transcription factor 4 is translationally regulated by hypoxic stress Mol Cell Biol 24 2004 7469 7482
    • (2004) Mol Cell Biol , vol.24 , pp. 7469-7482
    • Blais, J.D.1    Filipenko, V.2    Bi, M.3
  • 58
    • 1442307970 scopus 로고    scopus 로고
    • Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells
    • K. Ameri, C.E. Lewis, and M. Raida Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells Blood 103 2004 1876 1882
    • (2004) Blood , vol.103 , pp. 1876-1882
    • Ameri, K.1    Lewis, C.E.2    Raida, M.3
  • 59
    • 74849136799 scopus 로고    scopus 로고
    • Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia
    • T. Rzymski, M. Milani, and D.C. Singleton Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia Cell Cycle 8 2009 3838 3847
    • (2009) Cell Cycle , vol.8 , pp. 3838-3847
    • Rzymski, T.1    Milani, M.2    Singleton, D.C.3
  • 60
    • 84871882783 scopus 로고    scopus 로고
    • Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response
    • A. Nagelkerke, J. Bussink, and H. Mujcic Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response Breast Cancer Res 15 2013 R2
    • (2013) Breast Cancer Res , vol.15 , pp. R2
    • Nagelkerke, A.1    Bussink, J.2    Mujcic, H.3
  • 61
    • 84888096859 scopus 로고    scopus 로고
    • Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3
    • H. Mujcic, A. Nagelkerke, and K.M. Rouschop Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3 Clin Cancer Res 19 2013 6126 6137
    • (2013) Clin Cancer Res , vol.19 , pp. 6126-6137
    • Mujcic, H.1    Nagelkerke, A.2    Rouschop, K.M.3
  • 62
    • 84887024055 scopus 로고    scopus 로고
    • The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response
    • A. Nagelkerke, J. Bussink, and A.J. van der Kogel The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response Radiother Oncol 108 2013 415 421
    • (2013) Radiother Oncol , vol.108 , pp. 415-421
    • Nagelkerke, A.1    Bussink, J.2    Van Der Kogel, A.J.3
  • 63
    • 84893596560 scopus 로고    scopus 로고
    • LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy
    • A. Nagelkerke, A.M. Sieuwerts, and J. Bussink LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy Endocr Relat Cancer 21 2014 101 112
    • (2014) Endocr Relat Cancer , vol.21 , pp. 101-112
    • Nagelkerke, A.1    Sieuwerts, A.M.2    Bussink, J.3
  • 64
    • 84923259951 scopus 로고    scopus 로고
    • Therapeutic targeting of autophagy in cancer. Part I: Molecular pathways controlling autophagy
    • A. Nagelkerke, F.C. Sweep, and A. Geurts-Moespot Therapeutic targeting of autophagy in cancer. Part I: Molecular pathways controlling autophagy Semin Cancer Biol 2014 10.1016/j.semcancer.2014.05.004
    • (2014) Semin Cancer Biol
    • Nagelkerke, A.1    Sweep, F.C.2    Geurts-Moespot, A.3
  • 65
    • 84906273649 scopus 로고    scopus 로고
    • The unfolded protein response as a target for cancer therapy
    • A. Nagelkerke, J. Bussink, and F.C. Sweep The unfolded protein response as a target for cancer therapy Biochim Biophys Acta 1846 2014 277 284
    • (2014) Biochim Biophys Acta , vol.1846 , pp. 277-284
    • Nagelkerke, A.1    Bussink, J.2    Sweep, F.C.3
  • 66
    • 84923257166 scopus 로고    scopus 로고
    • Therapeutic targeting of autophagy in cancer. Part II: Pharmacological modulation of treatment-induced autophagy
    • A. Nagelkerke, J. Bussink, and A. Geurts-Moespot Therapeutic targeting of autophagy in cancer. Part II: Pharmacological modulation of treatment-induced autophagy Semin Cancer Biol 2014 10.1016/j.semcancer.2014.06.001
    • (2014) Semin Cancer Biol
    • Nagelkerke, A.1    Bussink, J.2    Geurts-Moespot, A.3
  • 67
    • 74949118681 scopus 로고    scopus 로고
    • The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
    • K.M. Rouschop, T. van den Beucken, and L. Dubois The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5 J Clin Invest 120 2010 127 141
    • (2010) J Clin Invest , vol.120 , pp. 127-141
    • Rouschop, K.M.1    Van Den Beucken, T.2    Dubois, L.3
  • 68
    • 84867206311 scopus 로고    scopus 로고
    • Activation of AKT by hypoxia: A potential target for hypoxic tumors of the head and neck
    • H. Stegeman, J.H. Kaanders, and D.L. Wheeler Activation of AKT by hypoxia: A potential target for hypoxic tumors of the head and neck BMC Cancer 12 2012 463
    • (2012) BMC Cancer , vol.12 , pp. 463
    • Stegeman, H.1    Kaanders, J.H.2    Wheeler, D.L.3
  • 69
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • E. Laughner, P. Taghavi, and K. Chiles HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression Mol Cell Biol 21 2001 3995 4004
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3
  • 70
    • 0036789574 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    • C.C. Hudson, M. Liu, and G.G. Chiang Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin Mol Cell Biol 22 2002 7004 7014
    • (2002) Mol Cell Biol , vol.22 , pp. 7004-7014
    • Hudson, C.C.1    Liu, M.2    Chiang, G.G.3
  • 71
    • 0035955406 scopus 로고    scopus 로고
    • Molecular biology. Glimpses of a tiny RNA world
    • G. Ruvkun Molecular biology. Glimpses of a tiny RNA world Science 294 2001 797 799
    • (2001) Science , vol.294 , pp. 797-799
    • Ruvkun, G.1
  • 72
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - MicroRNAs with a role in cancer
    • A. Esquela-Kerscher, and F.J. Slack Oncomirs - MicroRNAs with a role in cancer Nat Rev Cancer 6 2006 259 269
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 73
    • 78649378267 scopus 로고    scopus 로고
    • MicroRNA functions in stress responses
    • A.K. Leung, and P.A. Sharp MicroRNA functions in stress responses Mol Cell 40 2010 205 215
    • (2010) Mol Cell , vol.40 , pp. 205-215
    • Leung, A.K.1    Sharp, P.A.2
  • 74
    • 84886443752 scopus 로고    scopus 로고
    • MicroRNAs in the tumour microenvironment: Big role for small players
    • P. Soon, and H. Kiaris MicroRNAs in the tumour microenvironment: Big role for small players Endocr Relat Cancer 20 2013 R257 R267
    • (2013) Endocr Relat Cancer , vol.20 , pp. R257-R267
    • Soon, P.1    Kiaris, H.2
  • 76
    • 40949137731 scopus 로고    scopus 로고
    • Hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer
    • C. Camps, F.M. Buffa, and S. Colella hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer Clin Cancer Res 14 2008 1340 1348
    • (2008) Clin Cancer Res , vol.14 , pp. 1340-1348
    • Camps, C.1    Buffa, F.M.2    Colella, S.3
  • 77
    • 47049119934 scopus 로고    scopus 로고
    • MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3
    • P. Fasanaro, Y. DAlessandra, and V. Di Stefano MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3 J Biol Chem 283 2008 15878 15883
    • (2008) J Biol Chem , vol.283 , pp. 15878-15883
    • Fasanaro, P.1    Dalessandra, Y.2    Di Stefano, V.3
  • 78
    • 84902649752 scopus 로고    scopus 로고
    • Multiple functions of hypoxia-regulated miR-210 in cancer
    • Q. Qin, W. Furong, and L. Baosheng Multiple functions of hypoxia-regulated miR-210 in cancer J Exp Clin Cancer Res 33 2014 50
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 50
    • Qin, Q.1    Furong, W.2    Baosheng, L.3
  • 79
    • 84887463065 scopus 로고    scopus 로고
    • Epigenetic regulation of hypoxia-responsive gene expression: Focusing on chromatin and DNA modifications
    • Y.P. Tsai, and K.J. Wu Epigenetic regulation of hypoxia-responsive gene expression: Focusing on chromatin and DNA modifications Int J Cancer 134 2014 249 256
    • (2014) Int J Cancer , vol.134 , pp. 249-256
    • Tsai, Y.P.1    Wu, K.J.2
  • 80
    • 34147161066 scopus 로고    scopus 로고
    • Hypoxia-induced and stress-specific changes in chromatin structure and function
    • A.B. Johnson, and M.C. Barton Hypoxia-induced and stress-specific changes in chromatin structure and function Mutat Res 618 2007 149 162
    • (2007) Mutat Res , vol.618 , pp. 149-162
    • Johnson, A.B.1    Barton, M.C.2
  • 81
    • 40649114443 scopus 로고    scopus 로고
    • Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
    • A.B. Johnson, N. Denko, and M.C. Barton Hypoxia induces a novel signature of chromatin modifications and global repression of transcription Mutat Res 640 2008 174 179
    • (2008) Mutat Res , vol.640 , pp. 174-179
    • Johnson, A.B.1    Denko, N.2    Barton, M.C.3
  • 82
  • 83
    • 0036179376 scopus 로고    scopus 로고
    • Hypoxia links ATR and p53 through replication arrest
    • E.M. Hammond, N.C. Denko, and M.J. Dorie Hypoxia links ATR and p53 through replication arrest Mol Cell Biol 22 2002 1834 1843
    • (2002) Mol Cell Biol , vol.22 , pp. 1834-1843
    • Hammond, E.M.1    Denko, N.C.2    Dorie, M.J.3
  • 84
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • E.M. Hammond, M.J. Dorie, and A.J. Giaccia ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation J Biol Chem 278 14 2003 12207 12213
    • (2003) J Biol Chem , vol.278 , Issue.14 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 85
    • 0033572417 scopus 로고    scopus 로고
    • Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
    • R. Alarcón, C. Koumenis, and R.K. Geyer Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation Cancer Res 59 1999 6046 6051
    • (1999) Cancer Res , vol.59 , pp. 6046-6051
    • Alarcón, R.1    Koumenis, C.2    Geyer, R.K.3
  • 86
    • 84862278775 scopus 로고    scopus 로고
    • Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein
    • J.H. Lee, Y. Jin, and G. He Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein J Biol Chem 287 2012 20898 20903
    • (2012) J Biol Chem , vol.287 , pp. 20898-20903
    • Lee, J.H.1    Jin, Y.2    He, G.3
  • 87
  • 88
    • 33646229339 scopus 로고    scopus 로고
    • Genome-wide analysis of p53 under hypoxic conditions
    • E.M. Hammond, D.J. Mandell, and A. Salim Genome-wide analysis of p53 under hypoxic conditions Mol Cell Biol 26 2006 3492 3504
    • (2006) Mol Cell Biol , vol.26 , pp. 3492-3504
    • Hammond, E.M.1    Mandell, D.J.2    Salim, A.3
  • 89
    • 13944278507 scopus 로고    scopus 로고
    • The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality
    • T.M. Johnson, E.M. Hammond, and A. Giaccia The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality Nat Genet 37 2005 145 152
    • (2005) Nat Genet , vol.37 , pp. 145-152
    • Johnson, T.M.1    Hammond, E.M.2    Giaccia, A.3
  • 90
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • T.G. Graeber, C. Osmanian, and T. Jacks Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours Nature 379 1996 88 91
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 91
    • 35448940364 scopus 로고    scopus 로고
    • Adaptive landscapes and emergent phenotypes: Why do cancers have high glycolysis?
    • R.J. Gillies, and R.A. Gatenby Adaptive landscapes and emergent phenotypes: Why do cancers have high glycolysis? J Bioenerg Biomembr 39 2007 251 257
    • (2007) J Bioenerg Biomembr , vol.39 , pp. 251-257
    • Gillies, R.J.1    Gatenby, R.A.2
  • 92
    • 57749111596 scopus 로고    scopus 로고
    • Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
    • V. Ganapathy, M. Thangaraju, and P.D. Prasad Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond Pharmacol Ther 121 2009 29 40
    • (2009) Pharmacol Ther , vol.121 , pp. 29-40
    • Ganapathy, V.1    Thangaraju, M.2    Prasad, P.D.3
  • 94
    • 58149287834 scopus 로고    scopus 로고
    • Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage
    • M. Busk, M.R. Horsman, and S. Jakobsen Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage Eur J Nucl Med Mol Imaging 35 2008 2294 2303
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , pp. 2294-2303
    • Busk, M.1    Horsman, M.R.2    Jakobsen, S.3
  • 95
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • H. Lu, R.A. Forbes, and A. Verma Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis J Biol Chem 277 2002 23111 23115
    • (2002) J Biol Chem , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 96
    • 53049087909 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells
    • T. McFate, A. Mohyeldin, and H. Lu Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells J Biol Chem 283 2008 22700 22708
    • (2008) J Biol Chem , vol.283 , pp. 22700-22708
    • McFate, T.1    Mohyeldin, A.2    Lu, H.3


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