Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein

Journal of Biological Chemistry

Volumn 287, Issue 25, 2012, Pages 20898-20903

  Lee, Jun Ho ^a,d   Jin, Yetao ^a,e   He, Guifen ^a   Zeng, Shelya X ^a,b   Wang, Yunyuan V ^c   Wahl, Geoffrey M ^c   Lu, Hua ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d Seoul National University   (South Korea)

^e CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABNORMAL CONDITIONS; KINASE CASCADE; MOUSE EMBRYONIC FIBROBLASTS; NORMAL TISSUE; SOLID TUMORS; TUMOR SUPPRESSORS;

CELL CULTURE; ENZYMES; TUMORS;

PHOSPHORYLATION;

ALANINE; ATR PROTEIN; CHECKPOINT KINASE 1; MUTANT PROTEIN; PROTEIN 14 3 3; PROTEIN 14 3 3 GAMMA; PROTEIN MDMX; PROTEIN P53; PROTEIN SERINE THREONINE KINASE INHIBITOR; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

14-3-3 PROTEINS; ANIMALS; CELL CYCLE PROTEINS; CELL HYPOXIA; CELL LINE, TUMOR; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; MICE; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862278775     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.336875     Document Type: Article

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