메뉴 건너뛰기




Volumn 77, Issue 2, 2009, Pages 96-103

Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model

Author keywords

Angiogenesis; Glioblastoma multiforme; HIF 1 ; Hypoxia; Microenvironment; Pimonidazole; VEGF

Indexed keywords

VASCULOTROPIN;

EID: 60549104814     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2008.11.002     Document Type: Article
Times cited : (91)

References (49)
  • 3
    • 0025111609 scopus 로고
    • Tumour angiogenesis: the role of oncogenes and tumour suppressor genes
    • Bouck N. Tumour angiogenesis: the role of oncogenes and tumour suppressor genes. Cancer Cells 2 6 (1990) 179-185
    • (1990) Cancer Cells , vol.2 , Issue.6 , pp. 179-185
    • Bouck, N.1
  • 5
    • 0033769478 scopus 로고    scopus 로고
    • Optical sensorbased oxygen tension measurements correspond with hypoxia marker binding in three human tumor xenograft lines
    • Bussink J., Kaanders J.H., Strik A.M., Vojnovic B., and van Der Kogel A.J. Optical sensorbased oxygen tension measurements correspond with hypoxia marker binding in three human tumor xenograft lines. Radiat. Res. 154 5 (2000) 547-555
    • (2000) Radiat. Res. , vol.154 , Issue.5 , pp. 547-555
    • Bussink, J.1    Kaanders, J.H.2    Strik, A.M.3    Vojnovic, B.4    van Der Kogel, A.J.5
  • 6
    • 21344454671 scopus 로고    scopus 로고
    • Observation of incipient tumour angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation
    • Cao Y., Li C.Y., Moeller J.B., Yu D., Zhao Y., Dreher M.R., Shan S., and Dewhirst M.W. Observation of incipient tumour angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. Cancer Res. 65 13 (2005) 5498-5505
    • (2005) Cancer Res. , vol.65 , Issue.13 , pp. 5498-5505
    • Cao, Y.1    Li, C.Y.2    Moeller, J.B.3    Yu, D.4    Zhao, Y.5    Dreher, M.R.6    Shan, S.7    Dewhirst, M.W.8
  • 7
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology 69 Suppl.3 (2005) 4-10
    • (2005) Oncology , vol.69 , Issue.SUPPL.3 , pp. 4-10
    • Carmeliet, P.1
  • 8
    • 0033000313 scopus 로고    scopus 로고
    • Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia
    • Dewhirst M.W., Ong E.T., Braun R.D., Smith B., Klitzman B., Evans S.M., and Wilson D. Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. Br. J. Cancer 79 11-12 (1999) 1717-1722
    • (1999) Br. J. Cancer , vol.79 , Issue.11-12 , pp. 1717-1722
    • Dewhirst, M.W.1    Ong, E.T.2    Braun, R.D.3    Smith, B.4    Klitzman, B.5    Evans, S.M.6    Wilson, D.7
  • 9
    • 0037024440 scopus 로고    scopus 로고
    • Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis
    • Fenton B.M., Paoni S.F., Beauchamp B.K., and Ding I. Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis. Br. J. Cancer 86 (2002) 1831-1836
    • (2002) Br. J. Cancer , vol.86 , pp. 1831-1836
    • Fenton, B.M.1    Paoni, S.F.2    Beauchamp, B.K.3    Ding, I.4
  • 10
    • 85013312416 scopus 로고
    • Tumour angiogenesis: therapeutic implications
    • Folkman J. Tumour angiogenesis: therapeutic implications. N. Engl. J. Med. 285 (1971) 1182-1186
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 11
    • 0015311426 scopus 로고
    • Anti-angiogenesis: new concept for therapy of solid tumours
    • Folkman J. Anti-angiogenesis: new concept for therapy of solid tumours. Ann. Surg. 175 (1972) 409-416
    • (1972) Ann. Surg. , vol.175 , pp. 409-416
    • Folkman, J.1
  • 12
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • Folkman J., Watson K., Ingber D., and Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339 (1989) 5-61
    • (1989) Nature , vol.339 , pp. 5-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 14
    • 0030916215 scopus 로고    scopus 로고
    • A sensitive and robust assay for urokinase and tissue-type plasminogen activators (uPA and tPA) and their inhibitors type 1 (PAI-1) in breast tumour cytosols
    • Grebenschikov N., Geurts-Moespot A., Witte H., de Heuvel J., Leake R., Sweep F., and Benraad T. A sensitive and robust assay for urokinase and tissue-type plasminogen activators (uPA and tPA) and their inhibitors type 1 (PAI-1) in breast tumour cytosols. Int. J. Biol. Markers 12 1 (1997) 6-14
    • (1997) Int. J. Biol. Markers , vol.12 , Issue.1 , pp. 6-14
    • Grebenschikov, N.1    Geurts-Moespot, A.2    Witte, H.3    de Heuvel, J.4    Leake, R.5    Sweep, F.6    Benraad, T.7
  • 16
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumourigenesis
    • Hanahan D., and Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumourigenesis. Cell 86 3 (1996) 353-364
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 17
    • 48249143173 scopus 로고    scopus 로고
    • Comparison of angiogenesis-related factor expression in primary tumor cultures under normal and hypoxic growth conditions
    • Heinzman J.M., Brower S.L., and Bush J.E. Comparison of angiogenesis-related factor expression in primary tumor cultures under normal and hypoxic growth conditions. Cancer Cell Int. 8 11 (2008)
    • (2008) Cancer Cell Int. , vol.8 , Issue.11
    • Heinzman, J.M.1    Brower, S.L.2    Bush, J.E.3
  • 18
    • 41149138113 scopus 로고    scopus 로고
    • Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
    • Jain R.K. Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer. Nat. Rev. Cancer 8 4 (2008) 309-316
    • (2008) Nat. Rev. Cancer , vol.8 , Issue.4 , pp. 309-316
    • Jain, R.K.1
  • 21
    • 0035906856 scopus 로고    scopus 로고
    • 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon
    • Konerding M.A., Fait E., and Gaumann A. 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon. Br. J. Cancer 84 10 (2001) 1354-1362
    • (2001) Br. J. Cancer , vol.84 , Issue.10 , pp. 1354-1362
    • Konerding, M.A.1    Fait, E.2    Gaumann, A.3
  • 22
    • 0034021278 scopus 로고    scopus 로고
    • Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer
    • Leek R.D., Hunt N.C., Landers R.J., Lewis C.E., Royds J.A., and Harris A.L. Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J. Pathol. 190 (2000) 430-436
    • (2000) J. Pathol. , vol.190 , pp. 430-436
    • Leek, R.D.1    Hunt, N.C.2    Landers, R.J.3    Lewis, C.E.4    Royds, J.A.5    Harris, A.L.6
  • 24
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • Levy A.P., Levy N.S., and Goldberg M.A. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem. 271 (1996) 2746-2753
    • (1996) J. Biol. Chem. , vol.271 , pp. 2746-2753
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 25
    • 0034684999 scopus 로고    scopus 로고
    • Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models
    • Li C.Y., Shan S., Huang Q., Braun R.D., Lanzen J., Hu K., Lin P., and Dewhirst M.W. Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. J. Natl. Cancer Inst. 92 (2000) 143-147
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 143-147
    • Li, C.Y.1    Shan, S.2    Huang, Q.3    Braun, R.D.4    Lanzen, J.5    Hu, K.6    Lin, P.7    Dewhirst, M.W.8
  • 26
    • 34548018979 scopus 로고    scopus 로고
    • Visualization of hypoxia in microscopic tumours by immunofluorescent microscopy
    • Li X.F., Carlin S., Urano M., Russell J., Ling C.C., O, and ' Donoghue J.A. Visualization of hypoxia in microscopic tumours by immunofluorescent microscopy. Cancer Res. 67 16 (2007) 7646-7653
    • (2007) Cancer Res. , vol.67 , Issue.16 , pp. 7646-7653
    • Li, X.F.1    Carlin, S.2    Urano, M.3    Russell, J.4    Ling, C.C.5    O'Donoghue, J.A.6
  • 29
    • 0035951690 scopus 로고    scopus 로고
    • Intratumour heterogeneity in microvessel oxyhaemoglobin saturations
    • Måseide K., and Rofstad E.K. Intratumour heterogeneity in microvessel oxyhaemoglobin saturations. Cancer lett. 162 2 (2001) 245-251
    • (2001) Cancer lett. , vol.162 , Issue.2 , pp. 245-251
    • Måseide, K.1    Rofstad, E.K.2
  • 30
    • 1642329821 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer
    • Mizukami Y., Li J., Zhang X., Zimmer M.A., Iliopoulos O., and Chung D.C. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 64 (2004) 1765-1772
    • (2004) Cancer Res. , vol.64 , pp. 1765-1772
    • Mizukami, Y.1    Li, J.2    Zhang, X.3    Zimmer, M.A.4    Iliopoulos, O.5    Chung, D.C.6
  • 31
    • 33744914879 scopus 로고    scopus 로고
    • Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-Kinase/Rho/ROCK and c-Myc
    • Mizukami Y., Fujiki K., Duerr E.M., Gala M., Jo W.S., Zhang X., and Chung D.C. Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-Kinase/Rho/ROCK and c-Myc. J. Biol. Chem. 281 20 (2006) 13957-13963
    • (2006) J. Biol. Chem. , vol.281 , Issue.20 , pp. 13957-13963
    • Mizukami, Y.1    Fujiki, K.2    Duerr, E.M.3    Gala, M.4    Jo, W.S.5    Zhang, X.6    Chung, D.C.7
  • 32
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumours: role of reoxygenation, free radicals, and stress granules
    • Moeller B.J., Cao Y., Li C.Y., and Dewhirst M.W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumours: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5 (2004) 429-441
    • (2004) Cancer Cell , vol.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3    Dewhirst, M.W.4
  • 33
    • 48549083677 scopus 로고    scopus 로고
    • VEGFR3: a new target for antiangiogenesis therapy?
    • Padera T.P., and Jain R.K. VEGFR3: a new target for antiangiogenesis therapy?. Dev Cell. 15 2 (2008) 178-179
    • (2008) Dev Cell. , vol.15 , Issue.2 , pp. 178-179
    • Padera, T.P.1    Jain, R.K.2
  • 35
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9 (2003) 677-684
    • (2003) Nat. Med. , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 38
    • 0032801526 scopus 로고    scopus 로고
    • Comparisons among pimonidazole binding, oxygen electrode measurements and radiation response in C3H mouse tumours
    • Raleigh J.A., Chou S.C., Arteel G.E., and Horsman M.R. Comparisons among pimonidazole binding, oxygen electrode measurements and radiation response in C3H mouse tumours. Radiat. Res. 151 (1999) 580-589
    • (1999) Radiat. Res. , vol.151 , pp. 580-589
    • Raleigh, J.A.1    Chou, S.C.2    Arteel, G.E.3    Horsman, M.R.4
  • 39
    • 4444248801 scopus 로고    scopus 로고
    • Targeting chemotherapy-induced VEGF up-regulation by VEGF antisense oligonucleotides in HNSCC cell lines
    • Riedel F., Gotte K., Goessler U., Sadick H., and Hormann K. Targeting chemotherapy-induced VEGF up-regulation by VEGF antisense oligonucleotides in HNSCC cell lines. Anticancer Res. 24 (2004) 2179-2183
    • (2004) Anticancer Res. , vol.24 , pp. 2179-2183
    • Riedel, F.1    Gotte, K.2    Goessler, U.3    Sadick, H.4    Hormann, K.5
  • 40
    • 0029150035 scopus 로고
    • Application of an image analysis system to the quantitation of tumour perfusion and vascularity in human glioma xenografts
    • Rijken P.F.J.W., Bernsen H.J.J.A., and van der Kogel A.J. Application of an image analysis system to the quantitation of tumour perfusion and vascularity in human glioma xenografts. Microvasc. Res. 50 (1995) 141-153
    • (1995) Microvasc. Res. , vol.50 , pp. 141-153
    • Rijken, P.F.J.W.1    Bernsen, H.J.J.A.2    van der Kogel, A.J.3
  • 42
    • 0036270745 scopus 로고    scopus 로고
    • Quantitative analysis of varying profiles of hypoxia in relation to functional vessels in different human glioma xenograft lines
    • Rijken P.F.J.W., Peters J.P.W., and van der Kogel A.J. Quantitative analysis of varying profiles of hypoxia in relation to functional vessels in different human glioma xenograft lines. Radiat. Res. 157 (2002) 626-632
    • (2002) Radiat. Res. , vol.157 , pp. 626-632
    • Rijken, P.F.J.W.1    Peters, J.P.W.2    van der Kogel, A.J.3
  • 43
    • 0032473399 scopus 로고    scopus 로고
    • Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines
    • Scott P.A., Gleadle J.M., Bicknell R., and Harris A.L. Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines. Int. J. Cancer 75 (1998) 706-712
    • (1998) Int. J. Cancer , vol.75 , pp. 706-712
    • Scott, P.A.1    Gleadle, J.M.2    Bicknell, R.3    Harris, A.L.4
  • 44
    • 0029035872 scopus 로고
    • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumours
    • Secomb T.W., Hsu R., Ong E.T., Gross J.F., and Dewhirst M.W. Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumours. Acta Oncol. 34 (1995) 313-316
    • (1995) Acta Oncol. , vol.34 , pp. 313-316
    • Secomb, T.W.1    Hsu, R.2    Ong, E.T.3    Gross, J.F.4    Dewhirst, M.W.5
  • 45
    • 0034094192 scopus 로고    scopus 로고
    • EORTC Receptor and Biomarker Study Group report: a sandwich enzyme-linked immunosorbent assay for vascular endothelial growth factor in blood and tumour tissue extracts
    • Span P.N., Grebenschikov N., Geurts-Moespot J., Westphal J.R., Lucassen A.M.J., and Sweep C.G.J. EORTC Receptor and Biomarker Study Group report: a sandwich enzyme-linked immunosorbent assay for vascular endothelial growth factor in blood and tumour tissue extracts. Int. J. Biol. Markers 15 2 (2000) 184-191
    • (2000) Int. J. Biol. Markers , vol.15 , Issue.2 , pp. 184-191
    • Span, P.N.1    Grebenschikov, N.2    Geurts-Moespot, J.3    Westphal, J.R.4    Lucassen, A.M.J.5    Sweep, C.G.J.6
  • 46
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 47
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumourigenesis
    • Tang N., Wang L., Esko J., Giordano F.J.M., Huang Y., Gerber H.P., Ferrara N., and Johnson R.S. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumourigenesis. Cancer Cell 6 5 (2004) 485-495
    • (2004) Cancer Cell , vol.6 , Issue.5 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.M.4    Huang, Y.5    Gerber, H.P.6    Ferrara, N.7    Johnson, R.S.8
  • 48
    • 16844379943 scopus 로고    scopus 로고
    • Hypoxia and anemia: effects on tumour biology and treatment resistance
    • Vaupel P., and Mayer A. Hypoxia and anemia: effects on tumour biology and treatment resistance. Transfus. Clin. Biol. 12 (2005) 5-10
    • (2005) Transfus. Clin. Biol. , vol.12 , pp. 5-10
    • Vaupel, P.1    Mayer, A.2
  • 49
    • 8544221117 scopus 로고    scopus 로고
    • Vascular density in melanoma xenografts correlates with vascular permeability factor expression but not with metastatic potential
    • Westphal J.R., Van 't Hullenaar R.G.M., and Van der Laak J.A.W.M. Vascular density in melanoma xenografts correlates with vascular permeability factor expression but not with metastatic potential. Br. J. Cancer 76 (1997) 561-570
    • (1997) Br. J. Cancer , vol.76 , pp. 561-570
    • Westphal, J.R.1    Van 't Hullenaar, R.G.M.2    Van der Laak, J.A.W.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.