Genetic association studies of obesity in Africa: A systematic review

Obesity Reviews

Volumn 16, Issue 3, 2015, Pages 259-272

  Yako, Y Y ^a,b   Echouffo Tcheugui, J B ^c,d   Balti, E V ^e   Matsha, T E ^b   Sobngwi, E ^f   Erasmus, R T ^g   Kengne, A P ^a,h,i  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b CAPE PENINSULA UNIVERSITY OF TECHNOLOGY   (South Africa)

^c EMORY UNIVERSITY   (United States)

^d MEDSTAR HEALTH RESEARCH INSTITUTE   (United States)

^e VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^f UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^g UNIVERSITY OF STELLENBOSCH   (South Africa)

^h UNIVERSITY OF CAPE TOWN   (South Africa)

ⁱ UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Africa; Body mass index; Genetics; Obesity

Indexed keywords

ACE GENE; ADIPOQ GENE; AFRICA; AGRP GENE; AR GENE; C7ORF31 GENE; CAPN10 GENE; CD36 GENE; DNA POLYMORPHISM; DRD4 GENE; EMBASE; FTO GENE; GENE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GHANAIAN; HEREDITY; HUMAN; LEP GENE; MC3R GENE; MC4R GENE; MEDLINE; NIGERIAN; OBESITY; POPULATION GENETICS; POPULATION GROUP; REVIEW; SGIP1 GENE; SOUTH AFRICAN; STUDY DESIGN; SYSTEMATIC REVIEW; BLACK PERSON; BODY MASS; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; PHENOTYPE;

FTO PROTEIN, HUMAN; PROTEIN;

AFRICA; AFRICAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; OBESITY; PHENOTYPE; POLYMORPHISM, GENETIC; PROTEINS;

EID: 84923393610     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/obr.12260     Document Type: Review

References (83)

1. Kengne AP, Echouffo-Tcheugui J, Sobgnwi E, Mbanya JC. New insights on diabetes mellitus and obesity in Africa. Part 1: prevalence, pathogenesis and comorbidities. Heart 2013; 99: 979-983.
2. Hebebrand J, Hinney A. Environmental and genetic risk factors in obesity. Child Adolesc Psychiatr Clin N Am 2009; 18: 83-94.
3. Lu Y, Loos RJ. Obesity genomics: assessing the transferability of susceptibility loci across diverse populations. Genome Med 2013; 5: 55.
4. Monda KL, Chen GK, Taylor KC etal. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet 2013; 45: 690-696.
5. Wen W, Cho YS, Zheng W etal. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet 2012; 44: 307-311.
6. Adeyemo A, Chen G, Zhou J etal. FTO genetic variation and association with obesity in West Africans and African Americans. Diabetes 2010; 59: 1549-1554.
7. Bollepalli S, Dolan LM, Deka R, Martin LJ. Association of FTO gene variants with adiposity in African-American adolescents. Obesity (Silver Spring) 2010; 18: 1959-1963.
8. Grant SF, Li M, Bradfield JP etal. Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS ONE 2008; 3: e1746.
9. Kang SJ, Chiang CW, Palmer CD etal. Genome-wide association of anthropometric traits in African- and African-derived populations. Hum Mol Genet 2010; 19: 2725-2738.
10. Liu G, Zhu H, Lagou V etal. FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Genet 2010; 11: 57.
11. Ng MC, Hester JM, Wing MR etal. Genome-wide association of BMI in African Americans. Obesity (Silver Spring) 2012; 20: 622-627.
12. Wing MR, Ziegler JM, Langefeld CD etal. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. Int J Obes (Lond) 2011; 35: 1173-1182.
13. Sagoo GS, Little J, Higgins JP. Systematic reviews of genetic association studies. Human Genome Epidemiology Network. PLoS Med 2009; 6: e28.
14. Stroup DF, Berlin JA, Morton SC etal. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008-2012.
15. Kramer H, Wu X, Kan D etal. Angiotensin-converting enzyme gene polymorphisms and obesity: an examination of three black populations. Obes Res 2005; 13: 823-828.
16. Bonilla C, Panguluri RK, Taliaferro-Smith L etal. Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans. Int J Obes (Lond) 2006; 30: 715-721.
17. Matsha T, Fanampe B, Yako Y etal. Association of the ENPP1 rs997509 polymorphism with obesity in South African mixed ancestry learners. East Afr Med J 2010; 87: 323-329.
18. Yako YY, Fanampe BL, Hassan SM, Erasmus RT, van der Merwe L, Matsha TE. Negative association of MC3R variants with weight and blood pressure in Cape Town pupils aged 11-16 years. S Afr Med J 2011; 101: 417-420.
19. Gara S, Ochi H, Chango A etal. C677t polymorphism of MTHFR and G80A polymorphism of RFC genes and their relation with homocysteine levels in obese Tunisian children. Tunis Med 2011; 89: 565-568.
20. Zaki ME, Amr KS, Abdel-Hamid M. APOA2 polymorphism in relation to obesity and lipid metabolism. Cholesterol 2013; 2013: 289481.
21. Hennig BJ, Fulford AJ, Sirugo G etal. FTO gene variation and measures of body mass in an African population. BMC Med Genet 2009; 10: 21.
22. Eisenberg DT, Campbell B, Gray PB, Sorenson MD. Dopamine receptor genetic polymorphisms and body composition in undernourished pastoralists: an exploration of nutrition indices among nomadic and recently settled Ariaal men of northern Kenya. BMC Evol Biol 2008; 8: 173.
23. Joffe YT, van der Merwe L, Evans J etal. The tumor necrosis factor-alpha gene -238G>A polymorphism, dietary fat intake, obesity risk and serum lipid concentrations in black and white South African women. Eur J Clin Nutr 2012; 66: 1295-1302.
24. Yako YY, Fanampe BL, Hassan MS etal. Association of cocaine- and amphetamine-related transcript, leptin and leptin receptor gene polymorphisms with anthropometric obesity phenotype indicators in South African learners. J Nutrigenet Nutrigenomics 2011; 4: 210-221.
25. Lombard Z, Crowther NJ, van der Merwe L, Pitamber P, Norris SA, Ramsay M. Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study. BMJ Open 2012; 2(3). pii: e000873. doi: 10.1136/bmjopen-2012-000873.
26. Tsiotra PC, Boutati E, Dimitriadis G, Raptis SA. High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells. Biomed Res Int 2013; 2013: 487081.
27. Boumaiza I, Omezzine A, Rejeb J etal. Association between four resistin polymorphisms, obesity, and metabolic syndrome parameters in Tunisian volunteers. Genet Test Mol Biomarkers 2012; 16: 1356-1362.
28. Fourati M, Mnif M, Kharrat N etal. Association between Leptin gene polymorphisms and plasma leptin level in three consanguineous families with obesity. Gene 2013; 527: 75-81.
29. Ben Ali S, Kallel A, Sediri Y etal. LEPR p.Q223R Polymorphism influences plasma leptin levels and body mass index in Tunisian obese patients. Arch Med Res 2009; 40: 186-190.
30. Boumaiza I, Omezzine A, Rejeb J etal. Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. Genet Test Mol Biomarkers 2012; 16: 726-733.
31. Ben Ali S, Ben Yahia F, Sediri Y etal. Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. Clin Biochem 2009; 42: 1642-1647.
32. El-Shal AS, Pasha HF, Rashad NM. Association of resistin gene polymorphisms with insulin resistance in Egyptian obese patients. Gene 2013; 515: 233-238.
33. Bouhaha R, Baroudi T, Ennafaa H etal. Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population. Clin Biochem 2010; 43: 549-552.
34. Joffe YT, van der Merwe L, Carstens M etal. Tumor necrosis factor-alpha gene -308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African women. J Nutr 2010; 140: 901-907.
35. Joffe YT, van der Merwe L, Collins M etal. The -308 G/A polymorphism of the tumour necrosis factor-alpha gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African women. Genes Nutr 2011; 6: 353-359.
36. Frayling TM, Timpson NJ, Weedon MN etal. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894.
37. Scuteri A, Sanna S, Chen WM etal. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007; 3: e115.
38. Thorleifsson G, Walters GB, Gudbjartsson DF etal. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009; 41: 18-24.
39. Cha SW, Choi SM, Kim KS etal. Replication of genetic effects of FTO polymorphisms on BMI in a Korean population. Obesity (Silver Spring) 2008; 16: 2187-2189.
40. Hotta K, Nakata Y, Matsuo T etal. Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet 2008; 53: 546-553.
41. Tan JT, Dorajoo R, Seielstad M etal. FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. Diabetes 2008; 57: 2851-2857.
42. Villalobos-Comparan M, Teresa Flores-Dorantes M, Teresa Villarreal-Molina M etal. The FTO gene is associated with adulthood obesity in the Mexican population. Obesity (Silver Spring) 2008; 16: 2296-2301.
43. Wing MR, Ziegler J, Langefeld CD etal. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Hum Genet 2009; 125: 615-626.
44. Peters U, North KE, Sethupathy P etal. A systematic mapping approach of 16q12.2/FTO and BMI in more than 20, 000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. PLoS Genet 2013; 9: e1003171.
45. Loos RJ, Lindgren CM, Li S etal. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768-775.
46. Willer CJ, Speliotes EK, Loos RJ etal. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
47. Been LF, Nath SK, Ralhan SK etal. Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs. Obesity (Silver Spring) 2010; 18: 425-429.
48. Cheung CY, Tso AW, Cheung BM etal. Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population. J Clin Endocrinol Metab 2010; 95: 1395-1403.
49. Croteau-Chonka DC, Marvelle AF, Lange EM etal. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. Obesity (Silver Spring) 2011; 19: 1019-1027.
50. Huang W, Sun Y, Sun J. Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations. Endocrine 2011; 39: 69-74.
51. Taylor AE, Sandeep MN, Janipalli CS etal. Associations of FTO and MC4R variants with obesity traits in Indians and the role of rural/urban environment as a possible effect modifier. J Obes 2011; 2011: 307542.
52. Xi B, Chandak GR, Shen Y, Wang Q, Zhou D. Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis. PLoS ONE 2012; 7: e45731.
53. Hester JM, Wing MR, Li J etal. Implication of European-derived adiposity loci in African Americans. Int J Obes (Lond) 2012; 36: 465-473.
54. Jacobsson JA, Schioth HB, Fredriksson R. The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO. Obes Rev 2012; 13: 1096-1109.
55. Haupt A, Thamer C, Staiger H etal. Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes 2009; 117: 194-197.
56. Razquin C, Marti A, Martinez JA. Evidences on three relevant obesogenes: MC4R, FTO and PPARgamma. Approaches for personalized nutrition. Mol Nutr Food Res 2011; 55: 136-149.
57. Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 2008; 16: 1961-1965.
58. Beckers S, Zegers D, Van Gaal LF, Van Hul W. The role of the leptin-melanocortin signalling pathway in the control of food intake. Crit Rev Eukaryot Gene Expr 2009; 19: 267-287.
59. Smemo S, Tena JJ, Kim KH etal. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 2014; 507: 371-375.
60. Dankel SN, Fadnes DJ, Stavrum AK etal. Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS ONE 2010; 5: e11033.
61. Sanchez-Quinto F, Botigue LR, Civit S etal. North African populations carry the signature of admixture with Neandertals. PLoS ONE 2012; 7: e47765.
62. Petersen DC, Libiger O, Tindall EA etal. Complex patterns of genomic admixture within southern Africa. PLoS Genet 2013; 9: e1003309.
63. Amer MA, Ghattas MH, Abo-Elmatty DM, Abou-El-Ela SH. Evaluation of glutathione S-transferase P1 genetic variants affecting type-2 diabetes susceptibility and glycemic control. Arch Med Sci 2012; 8: 631-636.
64. Bayoumy NM, El-Shabrawi MM, Hassan HH. Association of cluster of differentiation 36 gene variant rs1761667 (G>A) with metabolic syndrome in Egyptian adults. Saudi Med J 2012; 33: 489-494.
65. El-Shal AS, Shalaby SM, Aly NM, Rashad NM, Abdelaziz AM. Genetic variation in the vitamin D receptor gene and vitamin D serum levels in Egyptian women with polycystic ovary syndrome. Mol Biol Rep 2013; 40: 6063-6073.
66. Ghattas MH, Mehanna ET, Mesbah NM, Abo-Elmatty DM. Association of estrogen receptor alpha gene polymorphisms with metabolic syndrome in Egyptian women. Metabolism 2013; 62: 1437-1442.
67. Jowett JB, Elliott KS, Curran JE etal. Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes. Diabetes 2004; 53: 2467-2472.
68. Cummings N, Shields KA, Curran JE etal. Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass. Int J Obes (Lond) 2012; 36: 201-206.
69. El Achhab Y, Meyre D, Bouatia-Naji N etal. Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population. Diabetes Metab 2009; 35: 37-42.
70. Argyropoulos G, Brown AM, Willi SM etal. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. J Clin Invest 1998; 102: 1345-1351.
71. Mayfield DK, Brown AM, Page GP, Garvey WT, Shriver MD, Argyropoulos G. A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes. Biochem Biophys Res Commun 2001; 287: 568-573.
72. Siffert W, Forster P, Jockel KH etal. Worldwide ethnic distribution of the G protein (beta)3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and black African individuals. J Am Soc Nephrol 1999; 10: 1921-1930.
73. Pegoraro RJ, Ranjith N, Rom L. Coagulation gene polymorphisms as risk factors for myocardial infarction in young Indian Asians. Cardiovasc J S Afr 2005; 16: 152-157.
74. Rooyen JM, Pretorius PJ, Britz M etal. Genetic polymorphisms of beta2- and beta3-adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women. Exp Clin Endocrinol Diabetes 2008; 116: 236-240.
75. Berman P, Collins M, Baumgarten I etal. Association between the 4 bp proinsulin gene insertion polymorphism (IVS-69) and body composition in black South African women. Obesity (Silver Spring) 2009; 17: 1298-1300.
76. Yako YY, Fanampe BL, Hassan SM, Erasmus RT, van der Merwe L, Matsha TE. Negative association of MC3R variants with weight and blood pressure in Cape Town pupils aged 11-16 years. S Afr Med J 2011; 101: 417-420.
77. Joffe YT, van der Merwe L, Evans J etal. Interleukin-6 gene polymorphisms, dietary fat intake, obesity and serum lipid concentrations in black and white South African women. Nutrients 2014; 6: 2436-2465.
78. Chouchane L, Danguir J, Beji C etal. Genetic variation in the stress protein hsp70-2 gene is highly associated with obesity. Int J Obes Relat Metab Disord 2001; 25: 462-466.
79. Ouederni TB, Sanchez-Corona J, Flores Martinez SE etal. The G1057D polymorphism of IRS-2 gene is not associated with type 2 diabetes and obese patients among ethnic groups in Tunisian population. Clin Biochem 2009; 42: 1169-1173.
80. Ezzidi I, Mtiraoui N, Nemr R etal. Variants within the calpain-10 gene and relationships with type 2 diabetes (T2DM) and T2DM-related traits among Tunisian Arabs. Diabetes Metab 2010; 36: 357-362.
81. Boumaiza I, Omezzine A, Rejeb J etal. Association between eight adiponectin polymorphisms, obesity, and metabolic syndrome parameters in Tunisian volunteers. Metab Syndr Relat Disord 2011; 9: 419-426.
82. Mehri S, Mahjoub S, Hammami S etal. Renin-angiotensin system polymorphisms in relation to hypertension status and obesity in a Tunisian population. Mol Biol Rep 2012; 39: 4059-4065.
83. Berhouma R, Kouidhi S, Ammar M, Abid H, Ennafaa H, Benammar-Elgaaied A. Correlation of peroxisome proliferator-activated receptor (PPAR-gamma) mRNA expression with Pro12Ala polymorphism in obesity. Biochem Genet 2013; 51: 256-263.