Association of the enpp1 rs997509 polymorphism with obesity in South African mixed ancestry learners

East African Medical Journal

Volumn 87, Issue 8, 2010, Pages 323-329

  Matsha, T ^a   Fanampe, B ^a   Yako, Y ^b   Hassan, S ^a   Hoffmann, M ^b   Van Der Merwe, L ^c,d   Erasmus, R T ^b  

^a CAPE PENINSULA UNIVERSITY OF TECHNOLOGY   (South Africa)

^b UNIVERSITY OF STELLENBOSCH   (South Africa)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^d UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; INORGANIC PYROPHOSPHATASE; PHOSPHODIESTERASE;

ADOLESCENT; ARTICLE; CASE CONTROL STUDY; CHILD; FEMALE; GENETICS; HUMAN; MALE; OBESITY; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH AFRICA;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; FEMALE; HUMANS; MALE; OBESITY; PHOSPHORIC DIESTER HYDROLASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PYROPHOSPHATASES; SOUTH AFRICA;

EID: 84875904268     PISSN: 0012835X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. South African Society for the Study of Obesity. SASSO Draft Guidelines on the prevention and management of overweight and obesity in South Africa. Reference Document, v10: For expert comment, February 2001.
2. Medical Research Council. Umthente uhlaba usamila: The 1 st South African National Youth Risk Behaviour Survey [online]. Pretoria: Department of Health, (2002). Available at http://www.mrc.ac.za/healthpromotion/healthpromotion.
3. Steyn, N.P., Labadarios, M.B., Mauder, E,. et al. Secondary anthropometric data analysis of the national food consumption survey in South Africa: The double burden. Nutrition 2005; 21: 4-13.
4. Armstrong, M.E., Lambert, M.I., Sharwood, K.A. and Lambert, E.V. Obesity and overweight in South African primary school children-the Health of the Nation Study. S. Afr. Med. J. 2006; 96: 439-444.
5. American Diabetes Association. Consensus Development Conference on Insulin Resistance. 1997 November 5-6, Diabetes Care 1998; 21: 310-314.
6. Yensel, C.S., Preud’homme, D. and Curry, D.M. Childhood obesity and insulin-resistant syndrome. J. Pediatr. Nurs. 2004; 19: 238-246.
7. Reaven, G.M. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
8. Eckel, R.H., Grundy, S.M. and Zimmet PZ. The metabolic syndrome, Lancet. 2005; 365: 1415-1428.
9. Matsha, T., Hassan, S., Bhata, A., et al. Metabolic Syndrome in 10-16 year old learners from the Western Cape, South Africa: Comparison of the NCEP ATP III and IDF criteria. Atherosclerosis. 2008; doi: 10.1016/j,atherosclerosis.
10. Chung, W.K. and Leibel, R.L. Molecular physiology of syndromic obesities in humans. Trends Endocrinol. Metab. 2005; 16: 261-272.
11. Maddux, B.A., Sbraccia, P., Kumakura, S., et al. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Nature 1995; 373: 448-451.
12. Maddux, B.A. and Goldfine, I.D. Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes 2000; 49:13-19.
13. Pizzuti, A., Frittitta, L., Argiolas, A., et al. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes. 1999; 48: 1881-1884.
14. M atsuoka, N., Patki, A., Tiwari, H.K., et al. Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults. Int. J. Obes. (London) 2006; 30: 233-237.
15. Goldfine, I.D., Maddux, S.A., Youngren, J.F., et al. The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities, Endocr Rev. 2008; 29:62-75.
16. Bochenski, J., Placha, G., Wanic, K., et al. New polymorphism of EN PP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals. Diabetes 2006 55: 2626-2630.
17. Santoro, N., Cirillo, G., Lepore, M.G., et al. Effect of the rs997509 Polymorphism on the Association between Ectonucleotide Pyrophosphatase Phosphodiesterase 1 and Metabolic Syndrome and Impaired Glucose Tolerance in Childhood Obesity. J Clin Endocrinol Metab. 2009; 94: 300-305.
18. Statistics South Africa-Census 2001. www.statssa.gov.za/census01/
19. Cole T J, Bellizzi MC, Flegal KM,. et al. Establishing a standard definition for child overweight and obesity worldwide: International survey. Brit. Med. J. 2000; 320: 1240-1243.
20. W orld Health Organization. International Society of Hypertension Guidelines for the Management of Hypertension. J. Hypertens 1999; 17: 151-183.
21. Hall, T. A. A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT, Acids Symp Ser 1999; 41: 95-98.
22. Abate, N., Chandalia, M., Satija, P., et al. ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes, Diabetes. 2005; 54: 1207-1213.
23. Abate, N., Carulli, L., Cabo-Chan, A. Jr., et al. Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance J. Clin. Endocrinol. Metab. 2003; 88: 5927-5934.
24. Kubaszek, A., Markkanen, A., Eriksson, J.G., et al. The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth. J. Clin. Endocrinol. Metab. 2004; 89: 2044-2047.
25. Gu, H.F., Almgren, P., Lindholm, E., et al. Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis, Diabetes 2000; 49:1601-1603.
26. Alberti, K.G., Zimmet, P. and Shaw, J. IDF Epidemiology Task Force Consensus Group, The metabolic syndrome--a new worldwide definition, Lancet. 2005; 366:1059-1062.
27. E xecutive summary of the clinical guidelines on the identification, evaluation and treatment of overweight and obesity in adults. Arch. Intern. Med. 1998; 158: 1581-1586.
28. 28, Lyon, H.N., Florez, J.C., Bersaglieri, T., et al. Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. Diabetes. 2006; 55: 3180-3184.
29. Chandalia, M., Grundy, S.M., Adams-Huet, B. and Abate, N. Ethnic differences in the frequency of EN PP1/PC1 121Q genetic variant in the Dallas Heart Study cohort. J. Diabetes Complicat. 2007; 21: 143-148.
30. T anyolac, S., Mahley, R.W., Hodoglugil, U. and Goldfine, I.D. Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population. Obesity. 2008; 16: 2468-2471.