Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers

Genetic Testing and Molecular Biomarkers

Volumn 16, Issue 7, 2012, Pages 726-733

  Boumaiza, Imen ^a   Omezzine, Asma ^a   Rejeb, Jihène ^a   Rebhi, Lamia ^a   Ouedrani, Amani ^a   Ben Rejeb, Nabila ^a   Nabli, Naoufel ^a   Ben Abdelaziz, Ahmed ^a   Bouslama, Ali ^a  

^a SAHLOUL UNIVERSITY HOSPITAL   (Tunisia)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LEPTIN RECEPTOR; LIPID;

ADULT; ARTICLE; BODY MASS; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIETARY INTAKE; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HUMAN; INSULIN RESISTANCE; INSULINEMIA; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MORBIDITY; OBESITY; WAIST CIRCUMFERENCE;

ADULT; AMINO ACID SUBSTITUTION; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL; ENERGY INTAKE; FEMALE; HAPLOTYPES; HUMANS; INSULIN; LEPTIN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; RECEPTORS, LEPTIN; RISK FACTORS; TUNISIA;

EID: 84863888278     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2011.0324     Document Type: Article

References (50)

1. Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539-553. (Pubitemid 28319935)
2. Alberti KG, Zimmet P, Shaw J (2005) The metabolic syndrome-a new worldwide definition. Lancet 366:1059-1062. (Pubitemid 41338752)
3. Ben Ali S, Kallel A, Ftouhi B, et al. (2009) Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients. Clin Biochem 42:584-588.
4. Boumaiza I, Omezzine A, Rejeb I, et al. (2011) Association between eight adiponectin polymorphisms, obesity and metabolic syndrome parameters in Tunisian volunteers. Metab Syndr Relat Disord 6:1-8.
5. Chagnon YC, Chung WK, Pérusse L, et al. (1999) Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Québec Family Study. Int J Obes Relat Metab Disord 23:278-286. (Pubitemid 29118858)
6. Chagnon YC, Wilmore JH, Borecki IB, et al. (2000) Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J Clin Endocrinol Metab 85:29-34. (Pubitemid 32268785)
7. Chobanian AV, Bakris GL, Black HR (2003) Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 289:2560-2572. (Pubitemid 37430158)
8. Chung WK, Power-Kehoe L, Chua M, et al. (1997) Exonic and intronic sequence variation in the human leptin receptor gene (LEPR). Diabetes 46:1509-1511. (Pubitemid 27369091)
9. Considine RV, Sinha MK, Heiman ML, et al. (1996) Serum im-munoreactive-leptin concentrations in normal weight and obese humans. N Engl J Med 334:292-295. (Pubitemid 26033933)
10. Constantin A, Costache G, Sima AV, et al. (2010) Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects. Biochem Biophys Res Commun 391:282-286.
11. Cummings DE, Schwartz MW (2003) Genetic and pathophysi-ology of human obesity. Annu Rev Med 54:453-471.
12. Duarte SFP, Francischetti EA, Genelhu VA, et al. (2007) LEPR p.Q223R, b3-AR p.W64R and LEP c-2548G> A gene variants in obese Brazilian subjects. Genet Mol Res 6:1035-1043. (Pubitemid 350292814)
13. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 285:2486-2497.
14. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clin Chem 18:499-502.
15. Fruhbeck G (2006) Intracellular signaling pathways activated by leptin. Biochem J 393:7-20. (Pubitemid 43049298)
16. Gong DW, Bi S, Pratley RE, et al. (1996) Genomic structure and promoter analysis of the human obese gene. J Biol Chem 271:3971-3974. (Pubitemid 26070491)
17. Gotoda T, Manning BS, Goldstone AP, et al. (1997) Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Genet 6:869-876. (Pubitemid 27239070)
18. Gottlieb MG, Bodanese LC, Leite LE, et al. (2009) Association between the Gln223Arg polymorphism of the leptin receptor and metabolic syndrome in free-living community elderly. Metab Syndr Relat Disord 7:341-348.
19. Heo M, Leibel RL, Fontaine KR, et al. (2002) A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. Int J Obes 26:640-646. (Pubitemid 34499283)
20. Hinuy HM, Hirata MH, Forti N, et al. (2008) Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women. Arq Bras Endocrinol Metab 52:611-616.
21. Hinuy HM, Hirata MH, Sampaio MF, et al. (2010) Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals. Arq Bras Endocrinol Metabol 54:282-288.
22. Hoffstedt J, Eriksson P, Mottagui-Tabar S, et al. (2002) A polymorphism in the leptin promoter region (-2548G/A) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res 34:355-359.
23. Huuskonen A, Lappalainen J, Tanskanen M, et al. (2010) Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training. Cell Biochem Funct 28:306-312.
24. Inui A (1999) Feeding and body-weight regulation by hypotha-lamic neuropeptides mediation of the actions of leptin. Trends Neurosci 22:62-67. (Pubitemid 29125552)
25. Le Stunff C, Le Bihan C, Schork NJ, et al. (2000) A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes 49:2196-2200.
26. Lowontin RC (1984) The interaction of selection and linkage 1. General considerations: heterotic models. Genetics 49:49-67.
27. Lu H, Sun J, Xu Y, et al. (2007) Association between the leptin receptor gene polymorphism and lipoprotein profile in chinese type 2 diabetes. Diabetes Metab Synd Clin Res Rev 1:259-265. (Pubitemid 47629716)
28. Mammès O, Betoulle D, Aubert R, et al. (2000) Association of the G-2548A polymorphism in the 5¢ region of the LEP gene with overweight. Ann Hum Genet 64:391-394. (Pubitemid 32055730)
29. Mattevi VS, Zembrzuski VM, Hutz MH (2002) Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord 26:1179-1185.
30. Matthews DR, Hosker JP, Rudenski AS, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419. (Pubitemid 15018832)
31. Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215.
32. Moshfegh AJ, Rhodes DG, Baer DJ, et al. (2008) The US Department of Agriculture automated multiple-pass method reduces bias in the collection of energy intakes. Am J Clin Nutr 88:324-332.
33. Otero M, Lago R, Lago F (2005) Leptin, from fat to inflammation: old questions and new inslights. FEBS Lett 579:295-301. (Pubitemid 40092403)
34. Paracchini V, Pedotti P, Taioli E (2005) Genetics of leptin and obesity: a huge review. Am J Epidemiol 162:101-114. (Pubitemid 41373535)
35. Portolés O, Sorĺi JV, Francés F, et al. (2006) Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. Eur J Epidemiol 21:605-612. (Pubitemid 44546622)
36. Quinton ND, Lee AJ, Ross RJ, et al. (2001) A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet 108:233-236. (Pubitemid 32293670)
37. Ren W, Zhang SH, Wu J, et al. (2004) Polymorphism of the leptin gene promoter in pedigrees of type 2 diabetes mellitus in Chongqing, China. Chin Med J 117:558-561. (Pubitemid 38579076)
38. Rosmond R, Chagnon YC, Holm G, et al. (2000) Hypertension in obesity and the leptin receptor gene locus. J Clin Endocrinol Metab 85:3126-3131.
39. Rossetti L, Massillon D, Barzilai N, et al. (1997) Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 272:27758-27763. (Pubitemid 27473574)
40. Seufert J (2004) Leptin effects on pancreatic beta-cell gene expression and function. Diabetes 53:152-158.
41. Steinberg GR, Bonen A, Dyck DJ (2002) Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats. Am J Physiol Endocrinol Metab 282:593-600.
42. Takahashi-Yasuno A, Masuzaki H, Miyawaki T, et al. (2003) Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by sim-vastatin in Japanese men. Diabetes Res Clin Pract 62:169-175. (Pubitemid 37414983)
43. Van der Vleuten GM, Kluijtmans LA, Hijmans A, et al. (2006) The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia. Int J Obes 30:892-898. (Pubitemid 43801187)
44. Walley AJ, Blakemore AI, Froguel P (2006) Genetics of obesity and the prediction of risk for health. Hum Mol Genet 15:124-130.
45. Wang TN, Huang MC, Chang WT, et al. (2006) G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity 14:183-187.
46. Wauters M, Considine RV, Chagnon M, et al. (2002) Leptin levels, leptin receptor gene polymorphisms, and energy metabolism in women. Obes Res 10:394-400. (Pubitemid 135688250)
47. World Health Organisation (1995) Physical status: the use and interpretation anthropometry: report of a WHO Expert Committee, WHO Technical Report Series. WHO, Geneva 854:321-344.
48. Yiannakouris N, Yannakoulia M, Relistas L, et al. (2001) The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin En-docrinol Metab 86:4434-4439. (Pubitemid 32848571)
49. Yoo J, Seo B, Kim Y (2005) SNP analyzer: a web-based integrated work bench for single nucleotide polymorphism analysis. Nucleic Acids Res 33:483-488.
50. Zhang Y, Proenca R, Maffei M, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432. (Pubitemid 24365442)