Association of FTO gene variants with adiposity in African-American adolescents

Obesity

Volumn 18, Issue 10, 2010, Pages 1959-1963

  Bollepalli, Sureka ^a   Dolan, Lawrence M ^a   Deka, Ranjan ^a   Martin, Lisa J ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FTO PROTEIN, HUMAN; PROTEIN;

ADOLESCENT; AFRICAN AMERICAN; ARTICLE; BODY MASS; CHILD; ETHNOLOGY; FEMALE; GENETICS; GENOTYPE; HUMAN; MALE; OBESITY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOSITY; ADOLESCENT; AFRICAN AMERICANS; BODY MASS INDEX; CHILD; FEMALE; GENOTYPE; HUMANS; MALE; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS;

EID: 77957105975     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2010.82     Document Type: Article

References (30)

1. Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006;295:1549-1555.
2. Serdula MK, Ivery D, Coates RJ, et al. Do obese children become obese adults? A review of the literature. Prev Med 1993;22:167-177.
3. Bao W, Srinivasan SR, Wattigney WA, Berenson GS. Persistence of multiple cardiovascular risk clustering related to syndrome X from childhood to young adulthood. The Bogalusa Heart Study. Arch Intern Med 1994;154:1842-1847.
4. Wattigney WA, Webber LS, Srinivasan SR, Berenson GS. The emergence of clinically abnormal levels of cardiovascular disease risk factor variables among young adults: the Bogalusa Heart Study. Prev Med 1995;24:617-626.
5. Demerath EW, Choh AC, Czerwinski SA, et al. Genetic and environmental influences on infant weight and weight change: the Fels Longitudinal Study. Am J Hum Biol 2007;19:692-702.
6. Wardle J, Carnell S, Haworth CM, Plomin R. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr 2008;87:398-404.
7. Rankinen T, Zuberi A, Chagnon YC, et al. The human obesity gene map: the 2005 update. Obesity (Silver Spring) 2006;14:529-644.
8. Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-726.
9. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894.
10. Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007;3:e115.
11. Grant SF, Li M, Bradfield JP, et al. Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS ONE 2008;3:e1746.
12. Wing MR, Ziegler J, Langefeld CD, et al. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Hum Genet 2009;125:615-626.
13. Dolan LM, Bean J, DAlessio D, et al. Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents. J Pediatr 2005;146:751-758.
14. Obesity and cardiovascular disease risk factors in black and white girls: the NHLBI Growth and Health Study. Am J Public Health 1992;82:1613-1620.
15. Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. Mapping complex disease loci in whole-genome association studies. Nature 2004; 429:446-452.
16. Peeters A, Beckers S, Verrijken A, et al. Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 2008;93:481-484.
17. Martin LJ, Woo JG, Avery CL, et al. Multiple testing in the genomics era: findings from Genetic Analysis Workshop 15, Group 15. Genet Epidemiol 2007;31 Suppl 1:S124-S131.
18. López-Bermejo A, Petry CJ, Díaz M, et al. The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks. J Clin Endocrinol Metab 2008;93:1501-1505.
19. Hunt SC, Stone S, Xin Y, et al. Association of the FTO gene with BMI. Obesity (Silver Spring) 2008;16:902-904.
20. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008;359:2558-2566.
21. Hakanen M, Raitakari OT, Lehtimäki T, et al. FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab 2009;94:1281-1287.
22. Haworth CM, Carnell S, Meaburn EL, et al. Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity (Silver Spring) 2008;16:2663-2668.
23. Müller TD, Hinney A, Scherag A, et al. Fat mass and obesity associated gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC Med Genet 2008;9:85.
24. Cossrow N, Falkner B. Race/ethnic issues in obesity and obesity-related comorbidities. J Clin Endocrinol Metab 2004;89:2590-2594.
25. Bacha F, Saad R, Gungor N, Janosky J, Arslanian SA. Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab 2003;88:2534-2540.
26. Church C, Lee S, Bagg EA, et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 2009;5:e1000599.
27. Fischer J, Koch L, Emmerling C, et al. Inactivation of the Fto gene protects from obesity. Nature 2009;458:894-898.
28. Gerken T, Girard CA, Tung YC, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007;318:1469-1472.
29. Haupt A, Thamer C, Staiger H, et al. Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes 2009;117:194-197.
30. Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 2008;16:1961-1965.