메뉴 건너뛰기




Volumn 40, Issue 3, 2009, Pages 186-190

LEPR p.Q223R Polymorphism Influences Plasma Leptin Levels and Body Mass Index in Tunisian Obese Patients

Author keywords

Body mass index; LEPR; Leptin; Polymorphism

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; LIPID;

EID: 67349258284     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2009.02.008     Document Type: Article
Times cited : (44)

References (34)
  • 1
    • 0000067107 scopus 로고    scopus 로고
    • Genetics and pathophysiology of human obesity
    • Cummings D.E., and Schwartz M.W. Genetics and pathophysiology of human obesity. Annu Rev Med 54 (2003) 453-471
    • (2003) Annu Rev Med , vol.54 , pp. 453-471
    • Cummings, D.E.1    Schwartz, M.W.2
  • 2
    • 33845567553 scopus 로고    scopus 로고
    • Genetics of obesity in humans
    • Farooqi S., and O'Rahilly S. Genetics of obesity in humans. Endocr Rev 27 (2006) 710-718
    • (2006) Endocr Rev , vol.27 , pp. 710-718
    • Farooqi, S.1    O'Rahilly, S.2
  • 3
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Hallaas J., Gajiwala K.S., Maffei M., et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 (1995) 543-546
    • (1995) Science , vol.269 , pp. 543-546
    • Hallaas, J.1    Gajiwala, K.S.2    Maffei, M.3
  • 4
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia L., Dembski M., Weng X., et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83 (1995) 1263-1271
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.1    Dembski, M.2    Weng, X.3
  • 5
    • 0034847530 scopus 로고    scopus 로고
    • The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability
    • Yiannakouris N., Yannakoulia M., Melistas L., Chan J.L., Klimis-Zacas D., and Mantzoros C. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab 86 (2001) 4434-4439
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4434-4439
    • Yiannakouris, N.1    Yannakoulia, M.2    Melistas, L.3    Chan, J.L.4    Klimis-Zacas, D.5    Mantzoros, C.6
  • 6
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • Lee G.H., Proenca R., Montez J.M., et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379 (1996) 632-635
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.H.1    Proenca, R.2    Montez, J.M.3
  • 7
    • 0030267744 scopus 로고    scopus 로고
    • Nonsense mutation of leptin receptor in obese spontaneously hypertensive Kolesky rat
    • Takaya K., Ogawa Y., Hiraoka J., et al. Nonsense mutation of leptin receptor in obese spontaneously hypertensive Kolesky rat. Nat Genet 14 (1996) 130-131
    • (1996) Nat Genet , vol.14 , pp. 130-131
    • Takaya, K.1    Ogawa, Y.2    Hiraoka, J.3
  • 8
    • 0344450708 scopus 로고    scopus 로고
    • A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    • Clément K., Vaisse C., Lahlou N., et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392 (1998) 398-401
    • (1998) Nature , vol.392 , pp. 398-401
    • Clément, K.1    Vaisse, C.2    Lahlou, N.3
  • 9
    • 3142728590 scopus 로고    scopus 로고
    • Tests of linkage and/or association of the LEPR gene polymoprhisms with obesity phenotypes in Caucasian nuclear families
    • Liu Y.J., Rocha-Sanchez S.M., and Liu P.Y. Tests of linkage and/or association of the LEPR gene polymoprhisms with obesity phenotypes in Caucasian nuclear families. Physiol Genomics 17 (2004) 101-106
    • (2004) Physiol Genomics , vol.17 , pp. 101-106
    • Liu, Y.J.1    Rocha-Sanchez, S.M.2    Liu, P.Y.3
  • 10
    • 9844266242 scopus 로고    scopus 로고
    • Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity
    • Matsuoka N., Ogawa Y., Hosoda K., et al. Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia 40 (1997) 1204-1210
    • (1997) Diabetologia , vol.40 , pp. 1204-1210
    • Matsuoka, N.1    Ogawa, Y.2    Hosoda, K.3
  • 11
    • 0030915473 scopus 로고    scopus 로고
    • Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians
    • Thompson D.B., Ravussin E., Bennett P.H., and Bogardus C. Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians. Hum Mol Genet 6 (1997) 975-979
    • (1997) Hum Mol Genet , vol.6 , pp. 975-979
    • Thompson, D.B.1    Ravussin, E.2    Bennett, P.H.3    Bogardus, C.4
  • 12
    • 0029885220 scopus 로고    scopus 로고
    • The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations
    • Considine R.V., Considine E.L., Williams C.J., Hyde T.M., and Caro J.F. The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 45 (1996) 992-994
    • (1996) Diabetes , vol.45 , pp. 992-994
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3    Hyde, T.M.4    Caro, J.F.5
  • 13
    • 0030927064 scopus 로고    scopus 로고
    • Leptin receptor gene variation and obesity: lack of association in a white British male population
    • Gotoda T., Manning B.S., Goldstone A.P., et al. Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Genet 6 (1997) 869-876
    • (1997) Hum Mol Genet , vol.6 , pp. 869-876
    • Gotoda, T.1    Manning, B.S.2    Goldstone, A.P.3
  • 14
    • 18344396039 scopus 로고    scopus 로고
    • A meta-analytic investigation of linkage, and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference
    • Heo M., Leibel R.L., Fontaine K.R., et al. A meta-analytic investigation of linkage, and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. Int J Obes Relat Metab Disord 26 (2002) 640-646
    • (2002) Int J Obes Relat Metab Disord , vol.26 , pp. 640-646
    • Heo, M.1    Leibel, R.L.2    Fontaine, K.R.3
  • 15
    • 0003588157 scopus 로고    scopus 로고
    • Physical status: The use and interpretation of anthropometry: Report of a WHO Expert Committee
    • World Health Organisation, 1995; No 854, pp, WHO: Geneva
    • World Health Organisation. Physical status: the use and interpretation of anthropometry: Report of a WHO Expert Committee, WHO Technical Report Series, 1995; No 854, pp. 321-344. WHO: Geneva.
    • WHO Technical Report Series , pp. 321-344
  • 16
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald W.T., Levy R.I., and Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18 (1972) 499-502
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 17
    • 0000135930 scopus 로고
    • Standardized Southern blot workshop techniques
    • Dupont B. (Ed), Springer, New York
    • Marcadet A., O'Connel P., and Cohen D. Standardized Southern blot workshop techniques. In: Dupont B. (Ed). Histocompatibility Testing (1987), Springer, New York 587-590
    • (1987) Histocompatibility Testing , pp. 587-590
    • Marcadet, A.1    O'Connel, P.2    Cohen, D.3
  • 18
    • 0030611940 scopus 로고    scopus 로고
    • The Gln223Arg and Lys656Asn polymorphisms in the human leptin receptor do not associate with traits related to obesity
    • Silver K., Walston J., Chung W.K., et al. The Gln223Arg and Lys656Asn polymorphisms in the human leptin receptor do not associate with traits related to obesity. Diabetes 46 (1997) 1898-1900
    • (1997) Diabetes , vol.46 , pp. 1898-1900
    • Silver, K.1    Walston, J.2    Chung, W.K.3
  • 19
    • 33947581477 scopus 로고    scopus 로고
    • LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity
    • Mergen H., Karaaslan C., Mergen M., Denïz Özsoy E., and Ozata M. LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity. Endocr J 54 (2007) 89-94
    • (2007) Endocr J , vol.54 , pp. 89-94
    • Mergen, H.1    Karaaslan, C.2    Mergen, M.3    Denïz Özsoy, E.4    Ozata, M.5
  • 20
    • 0036732501 scopus 로고    scopus 로고
    • Association analysis of genes involved in the leptin-signalling pathway with obesity in Brazil
    • Mattevi V.S., Zembrzuki V.M., and Hutz M.H. Association analysis of genes involved in the leptin-signalling pathway with obesity in Brazil. Int J Obes Relat Metab Disord 26 (2002) 1179-1185
    • (2002) Int J Obes Relat Metab Disord , vol.26 , pp. 1179-1185
    • Mattevi, V.S.1    Zembrzuki, V.M.2    Hutz, M.H.3
  • 21
    • 33746126567 scopus 로고    scopus 로고
    • p.Q223R leptin receptor polymorphism associated with obesity in Brazilian multiethnic subjects
    • Duarte S.F., Francischetti E.A., Genelhu-Abreu V.A., et al. p.Q223R leptin receptor polymorphism associated with obesity in Brazilian multiethnic subjects. Am J Hum Biol 18 (2006) 448-453
    • (2006) Am J Hum Biol , vol.18 , pp. 448-453
    • Duarte, S.F.1    Francischetti, E.A.2    Genelhu-Abreu, V.A.3
  • 23
    • 34249666244 scopus 로고    scopus 로고
    • Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women
    • Fairbrother U.L., Tankó L.B., Walley A.J., Christiansen C., Froguel P., and Blakemore A.I.F. Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. J Bone Mineral Res 22 (2007) 544-550
    • (2007) J Bone Mineral Res , vol.22 , pp. 544-550
    • Fairbrother, U.L.1    Tankó, L.B.2    Walley, A.J.3    Christiansen, C.4    Froguel, P.5    Blakemore, A.I.F.6
  • 24
    • 48349132166 scopus 로고    scopus 로고
    • Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population
    • Masuo K., Straznicky N.E., Lambert G.W., et al. Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population. Hypertens Res 31 (2008) 1093-1099
    • (2008) Hypertens Res , vol.31 , pp. 1093-1099
    • Masuo, K.1    Straznicky, N.E.2    Lambert, G.W.3
  • 25
    • 33749616410 scopus 로고    scopus 로고
    • Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain
    • Portolés O., Sorlí J.V., Francés F., et al. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. Eur J Epidemiol 21 (2006) 605-612
    • (2006) Eur J Epidemiol , vol.21 , pp. 605-612
    • Portolés, O.1    Sorlí, J.V.2    Francés, F.3
  • 26
    • 4243372108 scopus 로고    scopus 로고
    • Association of GLN223ARG polymorphism in the leptin receptor gene with serum leptin levels and BMI in postmenopausal Caucasian women
    • Blakemore A.I.F., Lee A.J., Quinton N.D., Ross R.J.M., and Eastell R. Association of GLN223ARG polymorphism in the leptin receptor gene with serum leptin levels and BMI in postmenopausal Caucasian women. Int J Obes Relat Metab Disord 22 (1998) S40
    • (1998) Int J Obes Relat Metab Disord , vol.22
    • Blakemore, A.I.F.1    Lee, A.J.2    Quinton, N.D.3    Ross, R.J.M.4    Eastell, R.5
  • 27
    • 0035073893 scopus 로고    scopus 로고
    • A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women
    • Quinton N.D., Lee A.J., Ross R.J., Eastell R., and Blakemore A.I. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet 108 (2000) 233-236
    • (2000) Hum Genet , vol.108 , pp. 233-236
    • Quinton, N.D.1    Lee, A.J.2    Ross, R.J.3    Eastell, R.4    Blakemore, A.I.5
  • 29
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine R.V., Sinha M.K., Heiman M.L., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334 (1996) 292-295
    • (1996) N Engl J Med , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 30
    • 0034457109 scopus 로고    scopus 로고
    • Leptin and aging: correlation with endocrine changes in male and female healthy adult population of different body weights
    • Isidori A.M., Strollo F., Morè M., et al. Leptin and aging: correlation with endocrine changes in male and female healthy adult population of different body weights. J Clin Endocrinol Metab 85 (2000) 1954-1962
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1954-1962
    • Isidori, A.M.1    Strollo, F.2    Morè, M.3
  • 31
    • 10144245924 scopus 로고    scopus 로고
    • Insulin and cortisol promote leptin production in cultured human fat cells
    • Wabitsch M., Jensen P.B., Blum W.F., et al. Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes 45 (1996) 1435-1438
    • (1996) Diabetes , vol.45 , pp. 1435-1438
    • Wabitsch, M.1    Jensen, P.B.2    Blum, W.F.3
  • 32
    • 19744366848 scopus 로고    scopus 로고
    • TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patients
    • Oge A., Bayraktar F., Saygili F., Guney E., and Demir S. TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patients. Endocr J 52 (2005) 213-217
    • (2005) Endocr J , vol.52 , pp. 213-217
    • Oge, A.1    Bayraktar, F.2    Saygili, F.3    Guney, E.4    Demir, S.5
  • 34
    • 33644852049 scopus 로고    scopus 로고
    • Leptin levels in pre- and post-menopausal Pakistani women
    • Ayub N., Khan S.R., and Syed F. Leptin levels in pre- and post-menopausal Pakistani women. J Pak Med Assoc 56 (2006) 3-5
    • (2006) J Pak Med Assoc , vol.56 , pp. 3-5
    • Ayub, N.1    Khan, S.R.2    Syed, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.