Study of TNFα-308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population

Clinical Biochemistry

Volumn 43, Issue 6, 2010, Pages 549-552

  Bouhaha, Rym ^a   Baroudi, Thouraya ^a   Ennafaa, Hajer ^a   Vaillant, Emanuel ^c   Abid, Hafawa ^b   Sassi, Rim ^a   Vatin, Vincent ^c   Froguel, Philippe ^c   Gaaied, Amel Benammar el ^a   Meyre, David ^c   Vaxillaire, Martine ^c  

^a FACULTÉ DES SCIENCES DE TUNIS   (Tunisia)

^b CHARLES NICOLLE HOSPITAL   (Tunisia)

^c INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Genetic polymorphisms; Inflammation; Obesity; Tunisian population; Type 2 diabetes

Indexed keywords

INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; IL6 PROTEIN, HUMAN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POPULATION RISK; PRIORITY JOURNAL; RISK ASSESSMENT; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; TUNISIA; AGED; CASE CONTROL STUDY; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PHYSIOLOGY; POPULATION GENETICS; PROMOTER REGION; RISK FACTOR;

ADULT; AGED; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GENOTYPE; HUMANS; INTERLEUKIN-6; LINKAGE (GENETICS); MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RISK FACTORS; TUMOR NECROSIS FACTOR-ALPHA; TUNISIA;

EID: 77950859077     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2010.01.008     Document Type: Article

References (37)

1. Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414(6865):782-787.
2. Haslam D.W., James W.P. Obesity. Lancet 2005, 36:1197-1209.
3. Bouguerra R., Alberti H., Salem L.B., et al. The global diabetes pandemic: the Tunisian experience. Eur. J. Clin. Nutr. 2007, 61:160-165.
4. Ben Amara H., Jelidi J., Bouguerra R., et al. Tunisian children reference for body mass index and prevalence of obesity. Tunis Med. 2008, 86(10):906-911.
5. Ben Mami Ben Miled F., Dakhli S., Blouza S., Achour A. Obesity in children. Tunis Med. 2000, 78(3):162-166.
6. Singh B., Mallika V., Goswami B. Metabolic syndrome: diagnosis, potential markers and management-an update. Clin. Chim. Acta 2006, 1.
7. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Ivest. 2003, 112:1796-1808.
8. Xu H., Barnes G.T., Yang Q., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Ivest. 2003, 112:1821-1830.
9. Hotamisgil G.S., Shargil N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
10. Zouari Bouassida K., Chouchane L., Jellouli K., et al. Polymorphism of stress protein HSP70-2 gene in Tunisian: susceptibility implications in type 2 diabetes and obesity. Diabetes Metab. 2004, 30:175-180.
11. David J., Mac Ewan TNF receptor subtype signalling: differences and cellular consequences. Cell. Signal. 2002, 14:477-492.
12. Chen Q., Pekala Phillip H. Tunor necrosis factor-α-induced insulin resistance in adipocytes. P. S. E. B. M. 2000, 223.
13. Sookoian S.C., González C., Pirola C.J. Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome. Obes. Res. 2005 Dec., 13(12):2122-2131.
14. Kubaszek A., Pihlajamäki J., Komarovski V., et al. Promoter polymorphisms of TNF-α (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. Diabetes 2003, 52:1872-1876.
15. Heijmans B.T., Westendorp R.G., Droog S., Kluft C., Knook D.L., Slagboom P.E. Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort. Genes Immun. 2002, 3(4):225-228.
16. Dalziel B., Gosby A.K., Richman R.M., Bryson J.M., Caterson I.D. Association of the TNF-alpha -308 G/A promoter polymorphism with insulin resistance in obesity. Obes. Res. 2002, 10(5):401-407.
17. Huth C., Heid I.M., Vollmert C., et al. IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies. Diabetes 2006, 55(10):2915-2921.
18. Hamid Y.H., Rose C.S., Urhammer S.A., et al. Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes. Diabetologia 2005, 48(2):251-260.
19. Wolford J.K., Colligan P.B., Gruber J.D., Bogardus C. Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Mol. Genet. Metab. 2003, 80(3):338-343.
20. Stephens J.W., Hurel S.J., Cooper J.A., Acharya J., Miller G.J., Humphries S.E. A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus. Mol. Genet. Metab. 2004, 82:180-186.
21. Vozarova B., Fernandez-Real J.M., Knowler W.C., et al. The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum. Genet. 2003, 112:409-413.
22. Zha J.M., DI W.J., Zhu T., et al. Comparison of gene transcription between subcutaneous and visceral adipose tissue in Chinese adults. Endocr. J. 2009, 30.
23. Heesen M., Wessiepe M., Kunz D., Vasickova K., Blomeke B. Rapid and reliable genotyping for the Toll-like receptor 4 A896G polymorphism using fluorescence-labeled hybridization probes in a real-time polymerase chain reaction assay. Clin. Chim. Acta 2003, 333:47-49.
24. Bouhaha R., Meyre D., Kamoun H.A., et al. Effect of ENPP1/PC-1-K121Q and PPARgamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population. Diabetes Res. Clin. Pract. 2008, 81(3):278-283.
25. Mohamed-Ali V., Goodrick S., Rawesh A., et al. Subcutaneous adipose tissue releases interrleukin-6, but not tumor necrosis factor-α in vivo. J. Clin. Endocrinol. Metab. 1997, 82:4196-4200.
26. Bastard J.P., Jardel C., Bruckert E., et al. Elevated levels of interleukins 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J. Clin. Endocrinol. Metab. 2000, 85:3338-3342.
27. Caro J.F., Sinha M.K., Kolaczybski J.W., Zhang P.L., Consdine R.V. Leptin: the tale of an obesity gene. Diabetes 1996, 45:1455-1462.
28. Ben Ali S., Kallel A., Ftouhi B., et al. Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients. Clin. Biochem. 2009, 42:584-588.
29. Huth C., Illig T., Herder C., Gieger C., et al. Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index. Ann. Med. 2009, 41(2):128-138.
30. Hamman A., Mantzoros C., Vidal-Puig A., Flier J.S. Genetic variability in the TNF- promoter is not associated with type 2 diabetes mellitus (NIDDM). Biochem. Biophys. Res. Commun. 1995, 211:833-839.
31. Fernández-Real J.M., Broch M., Vendrell J., et al. Interleukin-6 gene polymorphism and insulin sensitivity. Diabetes 2000, 49:517-520.
32. Kubaszek A., Pihlajamäki J., Punnonen K., et al. The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity. Diabetes 2003, 52:558-561.
33. Möhlig M., Boeing H., Spranger J., et al. Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes. J. Clin. Endocrinol. Metab. 2004, 89:1885-1890.
34. Vaxillaire M., Veslot J., Dina C., et al. DESIR Study Group. Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study. Diabetes 2008, 57(1):244-254.
35. Waltson J., Seibert M., Yen C.J., Cheskin L.J., Andersen R.E. Tumor necrosis factor α -238 and -308 polymorphisms do not associated to obesity and insulin resistance. Diabetes 1999, 48:2096-2098.
36. Cuenca J., Pérez C.A., Aguirre A.J., Schiattino I., Aguillón J.C. Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF): implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population. Biol. Res. 2001, 34(3-4):237-241.
37. Cherni L., Loueslati B.Y., Pereira L., Ennafaa H., Amorim A., El Gaaied A.B. Female gene pools of Berber and Arab neighboring communities in central Tunisia: microstructure of mtDNA variation in North Africa. Hum. Biol. 2005, 77(1):61-70.