Association of cocaine-and amphetamine-related transcript, leptin and leptin receptor gene polymorphisms with anthropometric obesity phenotype indicators in south african learners

Journal of Nutrigenetics and Nutrigenomics

Volumn 4, Issue 4, 2011, Pages 210-221

  Yako, Y Y ^a   Fanampe, B L ^b   Hassan, M S ^b   Erasmus, R T ^a   Van Der Merwe, L ^c,d   Van Rensburg, S J ^a,e   Matsha, T E ^b  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b CAPE PENINSULA UNIVERSITY OF TECHNOLOGY   (South Africa)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^d UNIVERSITY OF THE WESTERN CAPE   (South Africa)

^e STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Cocaine amphetamine related transcript; Leptin; Leptin receptor; Obesity

Indexed keywords

COCAINE AMPHETAMINE RELATED TRANSCRIPT; GHRELIN; LEPTIN; LEPTIN RECEPTOR; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ADOLESCENT; ANTHROPOMETRY; ARTICLE; BODY MASS; CHILD; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGRO; OBESITY; PHENOTYPE; PRIORITY JOURNAL; SCHOOL CHILD; WAIST CIRCUMFERENCE;

ADOLESCENT; ANTHROPOMETRY; BODY WEIGHTS AND MEASURES; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEARNING; LEPTIN; MALE; NERVE TISSUE PROTEINS; OBESITY; PHENOTYPE; POLYMORPHISM, GENETIC; POPULATION; RECEPTORS, LEPTIN; SCHOOLS; SOUTH AFRICA;

EID: 80052665495     PISSN: 16616499     EISSN: 16616758     Source Type: Journal    
DOI: 10.1159/000329614     Document Type: Article

References (58)

1. Puoane T, Steyn K, Bradshaw D, Laubscher R, Fourie J, Lambert V, Mbananga N: Obesity in South Africa: the South African demographic and health survey. Obes Res 2002; 10: 1038-1048. (Pubitemid 135688921)
2. Rocchini AP: Childhood obesity and a diabetes epidemic. N Engl J Med 2002; 346: 113-122.
3. Reddy SP, Resnicow K, James S, Kambaran N, Omardien R, Mbewu AD: Underweight, overweight and obesity among South African adolescents: results of the 2002 National Youth Risk Behaviour Survey. Public Health Nutr 2008; 12: 203-207.
4. Kimani-Murage EW, Kahn K, Pettifor JM, Tollman SM, Dunger DB, Gómez-Olivé XF, Norris SA: The prevalence of stunting, overweight and obesity, and metabolic disease risk in rural South African children. BMC Public Health 2010; 10: 158.
5. Mukuddem-Petersen J, Kruger HS: Association between stunting and overweight among 10-15-y-old children in the North West Province of South Africa: the THUSA BANA Study. Int J Obes Relat Metab Disord 2004; 28: 842-851. (Pubitemid 39005684)
6. Somers A, Hassan MS, Rusford E, Erasmus RT: Overweight and obesity in learners residing in the Belhar, Delft and Mfuleni communities of Cape Town, Western Cape, South Africa. Med Technol SA 2006; 20: 11-20.
7. Amstrong MEG, Lambert KA, Sharwood KA, Lambert EV: Obesity and overweight in South African primary school children-the Health of the Nation Study. S Afr Med J 2006; 96: 439-443.
8. Mvo Z, Dick J, Steyn K: Perceptions of overweight African women about acceptable body size of women and children. Curationis 1999; 22: 27-31.
9. Desmore A: The Cape Coloured people to-day: an address delivered to the league of Coloured peoples, London. Afr Aff 1937; 36: 347-356.
10. Wang Y, Lobstein T: Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 2006; 1: 11-25.
11. Rankinen T, Bray MS, Hagberg JM, Pérusse L, Roth SM, Wolfarth B, Bouchard C: The human gene map for performance and health-related fitness phenotypes: the 2005 update. Med Sci Sports Exerc 2006; 38: 1863-1888. (Pubitemid 44707790)
12. Frayling TM, Timpson NJ, Weedon MN, et al: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894. (Pubitemid 46764279)
13. Loos RJ, Lindgren CM, Li S, et al: Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768-775. (Pubitemid 351748863)
14. Willer CJ, Speliotes EK, Loos RJ: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
15. Flier JS: Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004; 116: 337-350. (Pubitemid 38167322)
16. Cone RD: Anatomy and regulation of the central melanocortin system. Nat Neurosci 2005; 8: 571-578. (Pubitemid 40594196)
17. Roth H, Korn T, Rosenkranz K, Hinney A: Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents. Hum Genet 1998; 103: 540-546. (Pubitemid 28548475)
18. Li WD, Reed DR, Lee JH, Xu W, Kilker RL, Sodam BR, Price RA: Sequence variants in the 5flanking region of the leptin gene are associated with obesity in women. Ann Hum Genet 1999; 63(Pt 3):227-234. (Pubitemid 29471966)
19. Chagnon YC, Wilmore JH, Borecki IB: Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J Clin Endocrinol Metab 2000; 85: 29-34. (Pubitemid 32268785)
20. Jiang Y, Wilk JB, Borecki I, et al: Common variants in the 5region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet 2004; 75: 220-230. (Pubitemid 38943865)
21. Lee YS, Poh LK, Kek BL, Loke KY: The role of melanocortin 3 receptor gene in childhood obesity. Diabetes 2007; 56: 2622-2630. (Pubitemid 47523271)
22. Mencarelli M, Walker GE, Maestrini S, et al: Sporadic mutations in melanocortin receptor 3 in morbid obese individuals. Eur J Hum Genet 2008; 16: 581-586. (Pubitemid 351594124)
23. Ando T, Ichimaru Y, Konjiki F, Shoji M, Komaki G: Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women. Am J Clin Nutr 2007; 86: 25-32. (Pubitemid 47041589)
24. Zwirska-Korczala K, Konturek SJ, Sodowski M, et al: Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome. J Physiol Pharmacol 2007; 58(suppl 1):13-35. (Pubitemid 350022256)
25. Steinle NI, Pollin TI, O'Connell JR, Mitchell BD, Shuldiner AR: Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish. J Clin Endocrinol Metab 2005; 90: 6672-6677. (Pubitemid 41759331)
26. Li WJ, Zhen YS, Sun K, et al: Ghrelin receptor gene polymorphisms are associated with female metabolic syndrome in Chinese population. Chin Med J (Engl) 2008; 121: 1666-1669.
27. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A: Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998; 19: 155-157. (Pubitemid 28248796)
28. Krude H, Biebermann H, Schnabel D, et al: Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J Clin Endocrinol Metab 2003; 88: 4633-4640. (Pubitemid 37357504)
29. Farooqi IS, Drop S, Clements A, et al: Heterozygosity for a POMC-null mutation and increased obesity risk in humans. Diabetes 2006; 55: 2549-2553. (Pubitemid 44871155)
30. Miraglia del Giudice E, Santoro N, Cirillo G, D'Urso L, Di Toro R, Perrone L: Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. Diabetes 2001; 50: 2157-2160. (Pubitemid 33643685)
31. Yamada K, Yuan X, Otabe S, Koyanagi A, Koyama W, Makita Z: Sequencing of the putative promoter region of the cocaine-and amphetamine-regulated-transcript gene and identification of polymorphic sites associated with obesity. Int J Obes Relat Metab Disord 2002; 26: 132-136. (Pubitemid 34098680)
32. Guérardel A, Barat-Houari M, Vasseur F, et al: Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population. BMC Genet 2005; 6: 19.
33. Yanik T, Dominguez G, Kuhar MJ, Del Giudice EM, Loh YP: The Leu34Phe ProCART mutation leads to cocaine-and amphetamine-regulated transcript (CART) deficiency: a possible cause for obesity in humans. Endocrinology 2006; 147: 39-43. (Pubitemid 43004260)
34. Rigoli L, Munafò C, Di Bella C, Salpietro A, Procopio V, Salpietro C: Molecular analysis of the CART gene in overweight and obese Italian children using family-based association methods. Acta Paediatr 2010; 99: 722-726.
35. Evans J, Collins M, Jennings C, et al: The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease. Eur J Endocrinol 2007; 157: 633-640. (Pubitemid 350187380)
36. Joffe YT, van der Merwe L, Carstens M, et al: Tumor necrosis factor-alpha gene-308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African women. J Nutr 2010; 140: 901-907.
37. Yako YY, Fanampe BL, Hassan MS, Erasmus RT, van der Merwe L, Matsha TE: Negative association of MC3R variants with weight and blood pressure in learners aged 11-16 years from Cape Town, South Africa. S Afr Med J 2011;101:417-420.
38. Matsha T, Hassan S, Bhata A, et al: Metabolic syndrome in 10-16-year-old learners from the Western Cape, South Africa: comparison of the NCEP ATP III and IDF criteria. Atherosclerosis 2009; 205: 363-365.
39. Retzlaff BM, Dowdy AA, Walden CE, Bovbjerg VE, Knopp RH: The Northwest Lipid Research Clinic Fat Intake Scale: validation and utility. Am J Public Health 1997; 87: 181-185. (Pubitemid 27120551)
40. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH: Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000; 320: 1240-1251.
41. Schaid DJ, Rowland CM, Tines DE, et al: Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002; 70: 425e34.
42. Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995; 57: 289-300.
43. Perneger TV: What's wrong with Bonferroni adjustments. BMJ 1998; 316: 1236-1238. (Pubitemid 28171344)
44. Nyholt DR: A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 2004; 74: 765-769. (Pubitemid 38420107)
45. Paracchini V, Pedotti P, Taioli E: Genetics of leptin and obesity: a HuGE review. Am J Epidemiol 2005; 162: 101-114. (Pubitemid 41373535)
46. Chomtho S, Fewtrell MS, Jaffe A, Williams JE, Wells JC: Evaluation of arm anthropometry for assessing pediatric body composition: evidence from healthy and sick children. Pediatr Res 2006; 59: 860-865. (Pubitemid 44297643)
47. Maz̈ćölu MM, Hatipölu N, Oztürk A, Ciçek B, Ustünbä HB, Kurtölu S: Waist circumference and mid-upper arm circumference in evaluation of obesity in children aged between 6 and 17 years. J Clin Res Pediatr Endocrinol 2010; 2: 144-150.
48. Quinton ND, Lee AJ, Ross RJ, Eastell R, Blakemore AI: A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet 2001; 108: 233-236. (Pubitemid 32293670)
49. Park KS, Shin HD, Park BL, et al: Polymorphisms in the leptin receptor (LEPR)-putative association with obesity and T2DM. J Hum Genet 2006; 51: 85-91.
50. Han HR, Ryu HJ, Cha HS, et al: Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. Clin Genet 2008; 74: 105-115. (Pubitemid 351974272)
51. Heo M, Leibel RL, Fontaine KR, et al: A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. Int J Obes Relat Metab Disord 2002; 26: 640-646. (Pubitemid 34499283)
52. Hager J, Clement K, Francke S, et al: A polymorphism in the 5untranslated region of the human ob gene is associated with low leptin levels. Int J Obes Relat Metab Disord 1998; 22: 200-205. (Pubitemid 28112018)
53. Hart Sailors ML, Folsom AR, Ballantyne CM, et al: Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. Diabetes Obes Metab 2007; 9: 548-557. (Pubitemid 47018518)
54. Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J: Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. Mol Genet Metab 2005; 86: 293-299. (Pubitemid 41412187)
55. Loos RJ, Rankinen T, Chagnon Y, Tremblay A, Pérusse L, Bouchard C: Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Québec Family Study. Int J Obes (Lond) 2006; 30: 183-190. (Pubitemid 41790796)
56. Souren NY, Paulussen AD, Steyls A, et al: Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins. Int J Obes (Lond) 2008; 32: 1233-1239.
57. Lakka TA, Rankinen T, Weisnagel SJ, et al: Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. Diabetes 2004; 53: 1603-1608. (Pubitemid 38697676)
58. Angeli CB, Kimura L, Auricchio MT, et al: Analyses of seven candidate genes suggest interacting pathways for obesity-related traits in Brazilian populations. Obesity (Silver Spring) 2011, E-pub ahead of print.