North African Populations Carry the Signature of Admixture with Neandertals

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Sánchez Quinto, Federico ^a   Botigué, Laura R ^a   Civit, Sergi ^c   Arenas, Conxita ^c   Ávila Arcos, María C ^d   Bustamante, Carlos D ^b   Comas, David ^a   Lalueza Fox, Carles ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CONTROLLED STUDY; ETHNIC DIFFERENCE; ETHNIC GROUP; EUROPEAN; GENE SIGNATURE; GENETIC ANALYSIS; GENOME; GENOTYPE; HOMO NEANDERTHALENSIS; HUMAN; MIGRATION; NORTH AFRICAN; SAHARAN; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICA SOUTH OF THE SAHARA; AFRICA, NORTHERN; ANIMALS; ASIA; EUROPE; GENE POOL; GENEALOGY AND HERALDRY; GENETICS, POPULATION; HUMANS; NEANDERTHALS; PRINCIPAL COMPONENT ANALYSIS;

EID: 84867649172     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047765     Document Type: Article

References (32)

1. Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, et al. (2010) A draft sequence of the Neandertal genome. Science 328: 710-722.
2. Reich D, Green RE, Kircher M, Krause J, Patterson N, et al. (2010) Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature 468: 1053-1060.
3. Reich D, Patterson N, Kircher M, Delfin F, Nandineni MR, et al. (2011) Denisova Admixture and the First Modern Human Dispersals into Southeast Asia and Oceania. Am J Hum Genet 89: 516-528.
4. Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, et al. (2011) The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans. Science 334: 89-94.
5. Hammer MF, Woerner AE, Mendez FL, Watkins JC, Wall JD, (2011) Genetic evidence for archaic admixture in Africa. Proc Natl Acad Sci USA 108: 15123-15128.
6. Rasmussen M, Guo X, Wang Y, Lohmueller KE, Rasmussen S, et al. (2011) An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia. Science 334: 94-98.
7. Yotova V, Lefebvre JF, Moreau C, Gbeha E, Hovhannesyan K, et al. (2011) An X-linked haplotype of Neandertal origin is present among all non-African populations. Mol Biol Evol 28: 1957-1962.
8. Eriksson A, Manica A, (2012) Effect of ancient population structure on the degree of polymorphism shared between modern human populations and ancient hominins. Proc Natl Acad Sci USA 109: 13956-13960.
9. Yang MA, Malaspinas AS, Durand EY, Slatkin M (2012) Ancient structure in Africa unlikely to explain Neanderthal and non-African genetic similarity. Mol Biol Evol Apr 18. [Epub ahead of print].
10. Osborne AH, Vance D, Rohling E, Barton N, Rogerson M, et al. (2008) A humid corridor across the Sahara for the migration "Out of Africa" of early modern humans 120,000 years ago. Proc Natl Acad Sci USA 105: 16444-16447.
11. Balter M, (2011) Was North African the launch pad for Modern Human migrations? Science 331: 20-23.
12. Barton RNE, Bouzouggar A, Collcutt SN, Schwenninger J-L, Clark-Balzan L, (2009) OSL dating of the Aterian levels at Grotte de Dar es-Soltan I (Rabat, Morocco) and possible implications for the dispersal of modern Homo sapiens. Quaternary Sci Rev 28: 1914-1931.
13. Garcea EAA (2010) The spread of Aterian peoples in North Africa. In: Garcea, E.A.A., editor. South-Eastern Mediterranean Peoples Between 130,000 and 10,000 years ago. Oxford: Oxbow Books.
14. Bouzouggar A, Barton RNE, Vanhaeren M, D'Errico F, Collcutt S, et al. (2007) 82,000-year-old shell beads from North Africa and implications for the origins of modern human behavior. Proc Natl Acad Sci USA 104: 9964-9969.
15. Harvati K, Hublin J-J (2012) Morphological continuity of the face in the late Middle and Upper Pleistocene hominins from northwestern Africa - A 3D geometric morphometric analysis. In: Hublin J-J, McPherron S, editors. Modern Origins: A North African Perspective. Dordrecht: Springer.
16. Hublin J-J, Verna C, Bailey S, Smith T, Olejniczak A, et al. (2012) Dental evidence from the Aterian human populations of morocco. In: Hublin J-J, McPherron S, editors. Modern Origins: A North African Perspective. Dordrecht: Springer.
17. Henn BM, Botigué LR, Gravel S, Wang W, Brisbin A, et al. (2012) Genomic ancestry of North Africans supports back-to-Africa migrations. Plos Genetics 8: e1002397.
18. Sankararaman S, Patterson N, Li H, Pääbo S, Reich D (2012) The date of interbreeding between Neandertals and modern humans. arXiv: 1208.2238v1.
19. International HapMap 3 Consortium, Altshuler DM, Gibbs RA, Peltonen L, Altshuler DM, et al (2010) Integrating common and ra genetic variation indiverse human populations. Nature 467: 52-57.
20. Novembre J, Johnson T, Bryc K, Kutalik Z, Boyko AR, et al. (2008) Genes mirror geography within Europe. Nature 456: 98-101.
21. Skoglund P, Malmström H, Raghavan M, Stora J, Hall P, et al. (2012) Origins and Genetic Legacy of Neolithic Farmers and Hunter-Gatherers in Europe. Science 336: 466-469.
22. Kuhner MK, Beerli P, Yamato J, Felsenstein J, (2000) Usefulness of single nucleotide polymorphism data for estimating population parameters. Genetics 156: 439-447.
23. Albrechtsen A, Nielsen FC, Nielsen R, (2010) Ascertainment biases in SNP chips affect measures of population divergence. Mol Biol Evol 27: 2534-2547.
24. Alexander DH, Novembre J, Lange K, (2009) Fast model-based estimation of ancestry in unrelated individuals. Genome Res 19: 1655-1664.
25. Hunter-Zinck H, Musharoff S, Salit J, Al-Ali KA, Chouchane L, et al. (2010) Population genetic structure of the people of Qatar. Am J Hum Genet 87: 17-25.
26. Lao O, Lu TT, Nothnagel M, Junge O, Freitag-Wolf S, et al. (2008) Correlation between genetic and geographic structure in Europe. Curr Biol 18: 1241-1248.
27. Reich D, Thangaraj K, Patterson N, Price AL, Singh L, (2009) Reconstructing Indian population history. Nature 461: 489-494.
28. Skoglund P, Jakobsson M, (2011) Archaic human ancestry in East Asia. Proc Natl Acad Sci USA 108: 18301-18306.
29. Kunsch HK, (1989) The jackknife and the bootstrap for general stationary observations. Ann Stat 17: 1217-1241.
30. Busing F, Meijer E, Van Der Leeden R, (1999) Delete-m jackknife for unequal m. Stat Comput 9: 3-8.
31. Durand EY, Patterson N, Reich D, Slatkin M, (2011) Testing for ancient admixture between closely related populations. Mol Biol Evol 28: 2239-2252.
32. Meyer M, Kircher M, Gansauge MT, Li H, Racimo F, et al. (2012) A High-Coverage Genome Sequence from an Archaic Denisovan Individual. Science. Aug 31. [Epub ahead of print].