Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells

Molecular Cancer Therapeutics

Volumn 14, Issue 2, 2015, Pages 586-596

  Dirat, Béatrice ^a,b   Ader, Isabelle ^c,d   Golzio, Muriel ^c,d   Massa, Fabienne ^a,b   Mettouchi, Amel ^a,b   Laurent, Kathiane ^a,b   Larbret, Frédéric ^b   Malavaud, Bernard ^c,d,e   Cormont, Mireille ^a,b   Lemichez, Emmanuel ^a,b   Cuvillier, Olivier ^c,d   Tanti, Jean Franҫois ^a,b   Bost, Frédéric ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^d UNIVERSITÉ PAUL SABATIER   (France)

^e CHU RANGUEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CHEMOKINE RECEPTOR CXCR4; CYCLIC AMP; DIHYDROTACHYSTEROL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; METFORMIN; P REX1 PROTEIN; RAC1 PROTEIN; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; PREX1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL MIGRATION; CELL MOTILITY; CYTOSKELETON; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER CELL LINE; SIGNAL TRANSDUCTION; ACTIN FILAMENT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MOTION; CELL PROLIFERATION; CHEMOTAXIS; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; MALE; METABOLISM; METASTASIS; NUDE MOUSE; PATHOLOGY; PROSTATE TUMOR; TUMOR CELL LINE; TUMOR INVASION;

ACTIN CYTOSKELETON; ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CXCL12; CHEMOTAXIS; CYCLIC AMP; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MALE; METFORMIN; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROSTATIC NEOPLASMS; RAC1 GTP-BINDING PROTEIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84923335695     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-14-0102     Document Type: Article

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