Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells

Molecular Medicine Reports

Volumn 5, Issue 4, 2012, Pages 1068-1074

  Esfahanian, Nilufar ^a   Shakiba, Yadollah ^b   Nikbin, Behroz ^b   Soraya, Hamid ^a   Maleki Dizaji, Nasrin ^a   Ghazi Khansari, Mahmood ^b   Garjani, Alireza ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Endothelial cells; Matrix metalloproteinase; Metformin; Migration; Proliferation

Indexed keywords

GELATINASE A; GELATINASE B; LACTATE DEHYDROGENASE; MESSENGER RNA; METFORMIN;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL;

AMP-ACTIVATED PROTEIN KINASES; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOGLYCEMIC AGENTS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; METFORMIN; PYRAZOLES; PYRIMIDINES;

EID: 84858268243     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.753     Document Type: Article

References (45)

1. Li D, Yeung SC, Hassan MM, Konopleva M and Abbruzzese JL: Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology 137: 482-488, 2009.
2. Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR and Morris AD: Metformin and reduced risk of cancer in diabetic patients. BMJ 330: 1304-1305, 2005. (Pubitemid 40813563)
3. Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD and Evans JM: New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 32: 1620-1625, 2009.
4. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, et al: Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108: 1167-1174, 2001. (Pubitemid 32995375)
5. Owen MR, Doran E and Halestrap AP: Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 15: 348, 2000.
6. Hay N and Sonenberg N: Upstream and downstream of mTOR. Genes Dev 18: 1926-1945, 2004. (Pubitemid 39071573)
7. Beevers CS, Li F, Liu L and Huang S: Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. Int J Cancer 119: 757-764, 2006. (Pubitemid 44051438)
8. Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR and Hardie DG: Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2: 28, 2003.
9. Lizcano JM, Goransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Makela TP, Hardie DG, et al: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 23: 833-843, 2004. (Pubitemid 38418750)
10. Ji H, Ramsey MR, Hayes DN, et al: LKB1 modulates lung cancer differentiation and metastasis. Nature 448: 807-810, 2007. (Pubitemid 47266337)
11. Folkman J and D'Amore PA: Blood vessel formation: what is its molecular basis? Cell 87: 1153-1155, 1996. (Pubitemid 27010098)
12. Kalluri R: Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 3: 422-433, 2003.
13. Haas TA: Endothelial cell regulation of matrix metalloproteinases. Can J Physiol Pharmacol 83: 1-7, 2005.
14. Sluijter JP, de Kleijin DP and Pasterkamp G: Vascular remodeling and protease inhibition: bench to bedside. Cardiovas Res 69: 595-603, 2006. (Pubitemid 43139723)
15. Tan BK, Adya R, Chen J, Farhatullah S, Heutling D, Mitchell D, Lehnert H and Randeva HS: Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1. Cardiovasc Res 83: 566-574, 2009.
16. Xavier DO, Amaral LS, Gomes MA, et al: Metformin inhibits inflammatory angiogenesis in a murine sponge model. Biomed Pharmacother 64: 220-225, 2010.
17. Linford NJ and Dorsa DM: 17beta-estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin. Steroids 67: 1029-1040, 2002. (Pubitemid 35345166)
18. Bowker SL, Majumdar SR, Veugelers P and Johnson JA: Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29: 254-258, 2006. (Pubitemid 44106500)
19. Currie CJ, Poole CD and Gale EA: The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 52: 1766-1777, 2009.
20. Wright JL and Stanford JL: Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study. Cancer Causes Control 20: 1617-1622, 2009.
21. Memmott RM, Mercado JR, Maier CR, Kawabata S, Fox SD and Dennis PA: Metformin prevents tobacco carcinogen - induced lung tumorigenesis. Cancer Prev Res (Phila) 3: 1066-1076, 2010.
22. Hwang YP and Jeong HG: Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Ca-dependent pathway: phorbol-12-myristate-13-acetate- induced/extracellular signal-regulated kinase/activator protein-1. Br J Pharmacol 160: 1195-1211, 2010.
23. Schafer G: Biguanides. A review of history, pharmacodynamics and therapy. Diabete Metab 9: 148-163, 1983.
24. Stumvoll M, Nurjhan N, Perriello G, Dailey G and Gerich JE: Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 333: 550-554, 1995.
25. Hundal RS, Krssak M, Dufour S, et al: Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 49: 2063-2069, 2000.
26. Hundal HS, Ramlal T, Reyes R, Leiter LA and Klip A: Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells. Endocrinology 131: 1165-1173, 1992.
27. Galuska D, Nolte LA, Zierath JR and Wallberg-Henriksson H: Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM. Diabetologia 37: 826-832, 1994. (Pubitemid 24247854)
28. Lin HZ, Yang SQ, Chuckaree C, Kuhajda F, Ronnet G and Diehl AM: Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med 6: 998-1003, 2000.
29. Hardie DG, Hawley SA and Scott JW: AMP-activated protein kinase - development of the energy sensor concept. J Physiol 574: 7-15, 2006. (Pubitemid 43905792)
30. Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J, Foretz M and Viollet B: 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 26: 5336-5347, 2006. (Pubitemid 44036203)
31. Li X, Han Y, Pang W, Li C, Xie X, Shyy JY and Zhu Y: AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb Vasc Biol 28: 1789-1795, 2008.
32. Nagata D, Mogi M and Walsh K: AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J Biol Chem 278: 31000-31006, 2003. (Pubitemid 36994613)
33. Kefas BA, Cai Y, Kerckhofs K, Ling Z, Martens G, Heimberg H, Pipeleers D and Van de Casteele M: Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochem Pharmacol 68: 409-416, 2004. (Pubitemid 38887423)
34. Saitoh M, Nagai K, Nakagawa K, Yamamura T, Yamamoto S and Nishizaki T: Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochem Pharmacol 67: 2005-2011, 2004. (Pubitemid 38591388)
35. Rattan R, Giri S, Singh AK and Singh I: 5-Aminoimidazole-4-carboxamide-1- beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem 280, 39582-39593, 2005. (Pubitemid 41713917)
36. Isakovic A, Harhaji L, Stevanovic D, Markovic Z, Sumarac-Dumanovic M, Starcevic V, Micic D and Trajkovic V: Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. Cell Mol Life Sci 64: 1290-1302, 2007. (Pubitemid 46791062)
37. Zhou W, Han WF, Landree LE, et al: Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Res 67: 2964-2971, 2007. (Pubitemid 46724832)
38. Okoshi R, Ozaki T, Yamamoto H, Ando K, Koida N, Ono S, Koda T, Kamijo T, Nakagawara A and Kizaki H: Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem 283: 3979-3987, 2008.
39. Alessi DR, Sakamoto K and Bayascas JR: LKB1-dependent signaling pathways. Annu Rev Biochem 75: 137-163, 2006. (Pubitemid 44118029)
40. Shaw MM, Gurr WK, McCrimmon RJ, Schorderet DF and Sherwin RS: 5′AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells. J Cell Mol Med 11: 286-298, 2007. (Pubitemid 46693327)
41. Antonoff MB and D'Cunha J: Teaching an old drug new tricks: metformin as a targeted therapy for lung cancer. Semin Thorac Cardiovasc Surg 22: 195-196, 2010.
42. Hong-Brown LQ, Brown CR, Huber DS and Lang CH: Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase. J Cell Biochem 105: 814-823, 2008.
43. Kim JE and Choi HC: Losartan inhibits vascular smooth muscle cell proliferation through activation of AMP-activated protein kinase. Korean J Physiol Pharmacol 14: 299-304, 2010.
44. Hanemaaijer R, Koolwijk P, le Clercq L, de Vree WJ and van Hinsbergh VW: Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor alpha, interleukin 1 and phorbol ester. Biochem J 15: 803-809, 1993. (Pubitemid 24008200)
45. Morizane Y, Thanos A, Takeuchi K, et al: AMP-activated protein kinase suppresses matix metalloproteinase-9 expression in mouse embryonic fibroblasts. J Biol Chem 286: 16030-16038, 2011.