Release of cAMP gating by the α6β4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells

Journal of Cell Biology

Volumn 143, Issue 6, 1998, Pages 1749-1760

  O'Connor, Kathleen L ^a   Shaw, Leslie M ^a   Mercurio, Arthur M ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cyclic AMP; Cytoskeleton; Integrin; Migration; Phosphodiesterase

Indexed keywords

CYCLIC AMP; INTEGRIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INVASION; CELL MIGRATION; CHANNEL GATING; CHEMOTAXIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS;

1-METHYL-3-ISOBUTYLXANTHINE; 1-PHOSPHATIDYLINOSITOL 3-KINASE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANTIBODIES; ANTIGENS, SURFACE; BREAST NEOPLASMS; CHEMOTAXIS; CULTURE MEDIA, CONDITIONED; CYCLIC AMP; FEMALE; FIBROBLASTS; FORSKOLIN; HUMANS; INTEGRIN ALPHA6BETA4; INTEGRINS; KINETICS; LYSOPHOSPHOLIPIDS; NEOPLASM INVASIVENESS; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINONES; ROLIPRAM; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0032517857     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.143.6.1749     Document Type: Article

References (8)

1. Aznavoorian, S., M.L. Stracke, J. Parsons, J. McClanahan, and L.A. Liotta. 1996. Integrin αvβ3 mediates chemotactic and haptotactic motility in human melanoma cells through different signaling pathways. J. Biol. Chem. 271:3247-3254.
2. Borradori, L., and A. Sonnenberg. 1996. Hemidesmosomes-roles in adhesion, signaling and human disease. Curr. Opin. Cell Biol. 8:647-656.
3. Chao, C., M.M. Lotz, A.C. Clarke, and A.M. Mercurio. 1996. A function for the integrin α6β4 in the invasive properties of colorectal carcinoma cells. Cancer Res. 56:4811-4819.
4. Clark, E.A., and J.S. Brugge. 1995. Integrins and signal transduction pathways: The road taken. Science. 268:233-239.
5. 4 integrin cytoplasmic domain. J. Biol. Chem. 270:22672-22676.
6. Conti, M., G. Nemoz, C. Sette, and E. Vicini. 1995. Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocrine Rev. 16:370-389.
7. Dexter, D.L., J.A. Barbosa, and P. Calabresi. 1979. N,N-dimethylformamide-induced alterations of cell culture characteristics and loss of tumorigenicity in cultured human colon carcinoma cells. Cancer Res. 39:1020-1025.
8. Domanico, S.Z., A.J. Pelletier, W.L. Havran, and V. Quaranta. 1997. Integrin α6Aβ1 induces CD81-dependent cell motility without engaging the extracellular matrix migation substrate. Mol. Biol. Cell. 8:2253-2265.