Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: Transfer of binding site to the CXCR3 receptor

Journal of Biological Chemistry

Volumn 279, Issue 4, 2004, Pages 3033-3041

  Rosenkilde, Mette M ^a   Gerlach, Lars Ole ^a,c   Jakobsen, Janus S ^a   Skerlj, Renato T ^b   Bridger, Gary J ^a,b   Schwartz, Thue W ^a,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b GENZYME CORPORATION   (United States)

^c 7TM Pharma A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CARBOXYLIC ACIDS; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE;

BIORECEPTORS; LIGANDS; PEPTIDES;

BIOCHEMISTRY;

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); CHEMOKINE RECEPTOR CXCR4;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BIOAVAILABILITY; CENTRAL NERVOUS SYSTEM; CHO CELL; DRUG ANTAGONISM; IMMUNE SYSTEM; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; TISSUE SPECIFICITY;

ANTI-HIV AGENTS; BINDING SITES; HETEROCYCLIC COMPOUNDS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 1642535388     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309546200     Document Type: Article

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