Rho GTPase, Rac1, regulates Skp2 levels, vascular smooth muscle cell proliferation, and intima formation in vitro and in vivo

Cardiovascular Research

Volumn 80, Issue 2, 2008, Pages 290-298

  Bond, Mark ^a   Wu, Yih Jer ^b,c   Sala Newby, Graciela B ^a   Newby, Andrew C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Cell cycle; Neointima; Rac; Skp2; Smooth muscle cell

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN B; CYCLIC AMP; CYTOCHALASIN D; FORSKOLIN; PROTEIN CDC42; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; ACTIN; BACTERIAL PROTEIN; BACTERIAL TOXIN; ENZYME INHIBITOR; RAC1 PROTEIN, RAT; S PHASE KINASE ASSOCIATED PROTEIN; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE; VIRUS RECOMBINANT; ANIMAL; BALLOON DILATATION; CAROTID ARTERY INJURY; CELL CULTURE; COMMON CAROTID ARTERY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; INTIMA; METABOLISM; MUTATION; PATHOLOGY; SIGNAL TRANSDUCTION; TIME;

ACTINS; ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BALLOON DILATATION; CAROTID ARTERY INJURIES; CAROTID ARTERY, COMMON; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC AMP; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; MALE; MUSCLE, SMOOTH, VASCULAR; MUTATION; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TUNICA INTIMA;

EID: 54149099613     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn188     Document Type: Article

References (37)

1. Assoian R, Marcantonio E. Cell adhesion in vascular biology: the extracellular matrix as a cell cycle control element in atherosclerosis and restenosis. J Clin Invest 1996;98:2436-2439.
2. Morgan D. Principles of CDK regulation. Nature 1995;374:131-134.
3. Sherr C, Roberts J. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995;9:1149-1163.
4. Fukumoto S, Koyama H, Hosoi M, Yamakawa K, Tanaka S, Morii H et al. Distinct role of cAMP and cGMP in the cell cycle control of vascular smooth muscle cells-cGMP delays cell cycle transition through suppression of cyclin D1 and cyclin-dependent kinase 4 activation. Circ Res 1999;85:985-991.
5. Koyama H, Raines EW, Bornfeldt KE, Roberts JM, Ross R. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Cell 1996;87:1069-1078.
6. Wu Y, Bond M, Sala-Newby G, Newby A. Altered S-phase kinase-associated protein-2 levels are a major mediator of cyclic nucleotide-induced inhibition of vascular smooth muscle cell proliferation. Circ Res 2006;98:1141- 1150.
7. Izzard T, Taylor C, Birkett S, Jackson C, Newby A. Mechanisms underlying maintenance of smooth muscle cell quiescence in rat aorta: role of the cyclin dependent kinases and their inhibitors. Cardiovasc Res 2002;52:242-252.
8. Tanner F, Yang Z, Duckers E, Gordon D, Nabel G, Nabel EG. Expression of cyclin-dependent kinase inhibitors in vascular disease. Circ Res 1998;82:396-403.
9. Carrano A, Eytan E, Hershko A, Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1999;1:193-199.
10. Bond M, Sala-Newby G, Newby A. Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. J Biol Chem 2004;279:37304-37310.
11. Villalonga P, Ridley AJ. Rho GTPases and cell cycle control. Growth Factors 2006;24:159-164.
12. Hall A. Rho GTPases and the actin cytoskeleton. Science 1998;279:509-514.
13. Welsh CF. Rho GTPases as key transducers of proliferative signals in G1 cell cycle regulation. Breast Cancer Res Treat 2004;84:33-42.
14. Pelletier S, Julien C, Popoff M, Lamarche-Vane N, Meloche S. Cyclic AMP induces morphological changes of vascular smooth muscle cells by inhibiting a Rac-dependent signaling pathway. J Cell Physiol 2005;204:412-422.
15. Bond M, Wu Y-J, Sala-Newby G, Newby A. Biphasic effect of p21Cip1 on vascular smooth muscle cell proliferation: role of PI3-kinase signalling and Skp2-mediated degradation. Cardiovasc Res 2005;69:198-206.
16. Clowes AW, Clowes M. Kinetics of cellular proliferation after arterial injury II. Inhibition of smooth muscle growth by heparin. Lab Invest 1985;52:611-616.
17. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest 1983;49:327-333.
18. Southgate K, Davies M, Booth R, Newby A. Involvement of extracellular matrix degrading metalloproteinases in rabbit aortic smooth muscle cell proliferation. Biochem J 1992;288:93-99.
19. Gjoerup O, Lukas J, Bartek J, Willumsen B. Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorlyation. J Biol Chem 1998;273:18812-18818.
20. Westwick J, Lambert Q, Clark G, Symons M, Aelst L, Pestell R et al. Rac regulation of transformation, gene expression, and actin organisation by multiple, PAK-independent pathways. Mol Cell Biol 1997;17:1324-1335.
21. Lamarche M, Tapan N, Stowers L, Burbelo P, Aspenstrom P, Brisges Tet al. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently. Cell 1996;87:519-529.
22. Wei W, Ayad N, Wan Y, Shabg G, Kirschner M, Kaelin W. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 2004;418:194-198.
23. Wirbelauer C, Sutterluty H, Blonel M, Gstaiger M, Peter M, Reymond F et al. The F-box protein Skp2 is a ubiquitinylation target of Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J 2000;19:5361- 5375.
24. Gjoerup O, Lukas J, Bartek J, Willumsen B. Rac and Cdc 42 are potent stimulators of E3F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation. J Biol Chem 1998;273:18812-18818.
25. Olson M, Ashworth A, Hall A. An essential role of Rho, Rac and Cdc42 GTPases in cell cycle progression through G1. Science 1995;269:1270-1272.
26. Qui R, Chen J, Kirn D, Mccormick F, Symons M. An essentail role for Rac in Ras transformation. Nature 1995;374:457-459.
27. Page K, Li D, Hodge JA, Liu PT, Vanden Hoek TL, Becker LB et al. Characterization of a rac1 signaling pathway to cyclin D-1 expression in airway smooth muscle cells. J Biol Chem 1999;274:22065-22071.
28. Huang S, Ingber D. A discrete cell cycle checkpoint in late G1 that is cytoskeleton-dependent and MAP Kinase (ERK)-independent. Exp Cell Res 2002;275:255-264.
29. Boulter E, Grall D, Cagnol S, Van Obberghen-Schilling E. Regulation of cell-matrix adhesion dynamics and Rac-1 by integrin linked kinase. FASEB J 2006;20:1489.
30. Hawkins PT, Eguinoa A, Qiu RG, Stokoe D, Cooke FT, Walters R et al. Pdgf stimulates an increase in Gtp-Rac via activation of phosphoinositide 3-kinase. Curr Biol 1995;5:393-403.
31. Guo D, Tan Y, Wang D, Madhusoodanan K, Zheng Y, Maack T et al. A Rac-cGMP signaling pathway. Cell 2007;10:341-355.
32. Shirotani M, Yui Y, Hattori R, Kawai C. U-61,431F, A stable prostacyclin analogue, inhibits the proliferation of bovine vascular smooth muscle cells with little antiproliferative effect on endothelial cells. Prostaglandins 1991;41:97-110.
33. Dubey R, Gillespie D, Jackson E. A2B adenosine receptors stimulate growth of porcine and rat arterial endothelial cells. Hypertension 2002;39:530-535.
34. Martinez J, Tavarez J, Oliveria C, Banerjee D. Potentiation of angiogenic switch in capillary endothelial cells by cAMP: a cross-talk between up-regulated LLO biosynthesis and the HSP-70 expression. Glycoconj J 2006;23:209-220.
35. Birukova S, Zagranichnaya T, Fu P, Alakseeva E, Chen W, Jacobson J et al. Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res 2007;313:2504-2520.
36. Asai J, Takenaka H, Katoh N, Kishimoto S. Dibutyryl cAMP influences endothelial progenitor cell recruitment during wound neovascularization. J Invest Dermatol 2006;126:1159-1167.
37. Carmona G, Chavakis E, Koehl U, Zeiher A, Dimmerler S. Activation of Epac stimulates integrin-dependent homing of progenitor cells. Blood 2008;111:2640-2646.