SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 286, Issue 5 49-5, 2004, Pages

  Dwinell, Michael B ^a,b   Ogawa, Hiroyuki ^a   Barrett, Kim E ^a   Kagnoff, Martin F ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Adenosine 3 ,5 cyclic monophosphate; Chemokine; Chemokine receptors; CXC chemokine ligand; CXC receptor; G protein coupled receptors; Ion transport; Stromal cell derived factor 1

Indexed keywords

ADENYLATE CYCLASE ACTIVATOR; CHEMOKINE RECEPTOR CXCR4; CXC CHEMOKINE LIGAND; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; LIGAND; PERTUSSIS TOXIN; PROTEIN SUBUNIT; RECEPTOR ANTIBODY; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CELL FUNCTION; CELL POLARITY; CELL STIMULATION; CELL STRAIN; COLON MUCOSA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; ION TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VOLTAGE CLAMP;

CELL LINE; CHEMOKINES, CXC; CYCLIC AMP; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; INTESTINAL MUCOSA; ION TRANSPORT; PROTO-ONCOGENE PROTEINS; RECEPTORS, CXCR4;

EID: 1942519774     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00112.2003     Document Type: Article

References (48)

1. Agace WW, Amara A, Roberts AI, Pablos JL, Thelen S, Uguccioni M, Li XY, Marsal J, Arenzana-Seisdedos F, Delaunay T, Ebert EC, Moser B, and Parker CM. Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation. Curr Biol 10: 325-328, 2000.
2. Antoni FA. Molecular diversity of cyclic AMP signalling. Front Neuroendocrinol 21: 103-132, 2000.
3. Bamba H, Ota S, Kato A, Kawamoto C, and Matsuzaki F. Effect of prostaglandin E1 on vascular endothelial growth factor production by human macrophages and colon cancer cells. J Exp Clin Cancer Res 19: 219-223, 2000.
4. Barrett KE and Keely SJ. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu Rev Physiol 62: 535-572, 2000.
5. Bertelsen LS, Paesold G, Eckmann L, and Barrett KE. Salmonella infection induces a hypersecretory phenotype in human intestinal xenografts by inducing cyclooxygenase 2. Infect Immun 71: 2102-2109, 2003.
6. Binion DG, West GA, Ina K, Ziats NP, Emancipator SN, and Fiocchi C. Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 112: 1895-1907, 1997.
7. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, and Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med 184: 1101-1109, 1996.
8. Brand S, Sakaguchi T, Gu X, Colgan SP, and Reinecker HC. Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells. Gastroenterology 122: 166-177, 2002.
9. --secreting epithelial cells. Proc NatlAcad Sci USA 87: 4956-4960, 1990.
10. Dharmsathaphorn K, McRoberts JA, Mandel KG, Tisdale LD, and Masui H. A human colonic tumor cell line that maintains vectorial electrolyte transport. Am J Physiol Gastrointest Liver Physiol 246: G204-G208, 1984.
11. Dwinell MB, Eckmann L, Leopard JD, Varki NM, and Kagnoff MF. Chemokine receptor expression by human intestinal epithelial cells. Gastroenterology 117: 359-367, 1999.
12. Dwinell MB, Lugering N, Eckmann L, and Kagnoff MF. Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells. Gastroenterology 120: 49-59, 2001.
13. Eckmann L, Jung HC, Schurer-Maly C, Panja A, Morzycka-Wroblewska E, and Kagnoff MF. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8. Gastroenterology 105: 1689-1697, 1993.
14. Eckmann L, Smith JR, Housley MP, Dwinell MB, and Kagnoff MF. Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella. J Biol Chem 275: 14084-14094, 2000.
15. Eckmann L, Stenson WF, Savidge TC, Lowe DC, Barrett KE, Fierer J, Smith JR, and Kagnoff MF. Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2α production. J Clin Invest 100: 296-309, 1997.
16. Fedyk ER, Jones D, Critchley HO, Phipps RP, Blieden TM, and Springer TA. Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing. J Immunol 166: 5749-5754, 2001.
17. Garcia-Bermejo L, Perez C, Vilaboa NE, de Blas E, and Aller P. cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells. J Cell Sci 111: 637-644, 1998.
18. Han Y, He T, Huang DR, Pardo CA, and Ransohoff RM. TNF-α mediates SDF-1α-induced NF-κB activation and cytotoxic effects in primary astrocytes. J Clin Invest 108: 425-435, 2001.
19. Hecht G. Innate mechanisms of epithelial host defense: spotlight on intestine. Am J Physiol Cell Physiol 277: C351-C358, 1999.
20. Heidemann J, Ogawa H, Dwinell MB, Rafiee P, Maaser C, Gockel HR, Otterson MF, Ota DM, Lugering N, Domschke W, and Binion DG. Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J Biol Chem 278: 8508-8512, 2003.
21. Hesselgesser J, Liang M, Hoxie J, Greenberg M, Brass LF, Orsini MJ, Taub D, and Horuk R. Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity. J Immunol 160: 877-883, 1998.
22. Izadpanah A, Dwinell MB, Eckmann L, Varki NM, and Kagnoff MF. Regulated MIP-3α/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. Am J Physiol Gastrointest Liver Physiol 280: G710-G719, 2001.
23. Jordan NJ, Kolios G, Abbot SE, Sinai MA, Thompson DA, Petraki K, and Westwick J. Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. J Clin Invest 104: 1061-1069, 1999.
24. + cells: evidence for an autocrine/paracrine mechanism. Blood 99: 1117-1129, 2002.
25. Levite M and Chowers Y. Nerve-driven immunity: neuropeptides regulate cytokine secretion of T cells and intestinal epithelial cells in a direct, powerful and contextual manner. Ann Oncol 12, Suppl 2: S19-S25, 2001.
26. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, and Springer TA. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 95: 9448-9453, 1998.
27. Madsen HO, Garred P, Thiel S, Kurtzhals JA, Lamm LU, Ryder LP, and Svejgaard A. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J Immunol 155: 3013-3020, 1995.
28. 2+ inhibition of VIP- and A23187-stimulated Cl-secretion by T84 cell monolayers. Am J Physiol Cell Physiol 250: C486-C494, 1986.
29. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verastegui E, and Zlotnik A. Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56, 2001.
30. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, and Kishimoto T. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382: 635-638, 1996.
31. Nanki T, Hayashida K, El Gabalawy HS, Suson S, Shi K, Girschick HJ, Yavuz S, and Lipsky PE. Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium. J Immunol 165: 6590-6598, 2000.
32. Neish AS. The gut microflora and intestinal epithelial cells: a continuing dialogue. Microbes Infect 4: 309-317, 2002.
33. Neves SR, Ram PT, and Iyengar R. G protein pathways. Science 296: 1636-1639, 2002.
34. Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, and Moser B. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382: 833-835, 1996.
35. Pai R, Soreghan B, Szabo IL, Pavelka M, Baatar D, and Tarnawski AS. Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med 8: 289-293, 2002.
36. Papadakis KA and Targan SR. The role of chemokines and chemokine receptors in mucosal inflammation. Inflamm Bowel Dis 6: 303-313, 2000.
37. Resta-Lenert S, Truong F, Barrett KE, and Eckmann L. Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity. Am J Physiol Cell Physiol 281: C1837-C1849, 2001.
38. Rollins BJ. Chemokines. Blood 90: 909-928, 1997.
39. Rossi D and Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol 18: 217-242, 2000.
40. Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Boulay G, Bradley A, and Birnbaumer L. Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice. Nat Genet 10: 143-150, 1995.
41. Sallusto F, Lanzavecchia A, and Mackay CR. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today 19: 568-574, 1998.
42. Scotton CJ, Wilson JL, Milliken D, Stamp G, and Balkwill FR. Epithelial cancer cell migration: a role for chemokine receptors? Cancer Res 61: 4961-4965, 2001.
43. Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara T, and Honjo T. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics 28: 495-500, 1995.
44. Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, Rosenkilde MM, Schwartz TW, Holmes W, Dallas W, Luther MA, Wells TN, Hoxie JA, and Marsh M. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J Cell Biol 139: 651-664, 1997.
45. Strober W. Interactions between epithelial cells and immune cells in the intestine. Ann NY Acad Sci 859: 37-45, 1998.
46. Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, Kishimoto T, and Nagasawa T. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393: 591-594, 1998.
47. Warhurst G, Higgs NB, Fakhoury H, Warhurst AC, Garde J, and Coy DH. Somatostatin receptor subtype 2 mediates somatostatin inhibition of ion secretion in rat distal colon. Gastroenterology 111: 325-333, 1996.
48. Yang SK, Eckmann L, Panja A, and Kagnoff MF. Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology 113: 1214-1223, 1997.