Translocator protein 18 kDa (TSPO) expression in multiple sclerosis patients

Journal of Neuroimmune Pharmacology

Volumn 8, Issue 1, 2013, Pages 51-57

  Harberts, Erin ^a   Datta, Dibyadeep ^a   Chen, Selby ^a   Wohler, Jillian E ^a   Oh, Unsong ^a   Jacobson, Steven ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Multiple sclerosis; Neuroinflammation; PBR28; TSPO

Indexed keywords

N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; OUTER MEMBRANE PROTEIN; TRANSLOCATOR PROTEIN 18 KDA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOCYTE; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETAMIDES; ADULT; ANTIGENS, CD14; BIOLOGICAL MARKERS; BRAIN; CELL SEPARATION; FEMALE; HUMANS; ISOQUINOLINES; LEUKOCYTES, MONONUCLEAR; MAGNETIC RESONANCE IMAGING; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; MITOCHONDRIA; MULTIPLE SCLEROSIS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PYRIDINES; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, GABA;

EID: 84874648380     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-012-9397-5     Document Type: Article

References (30)

1. Banati RB (2002) Visualising microglial activation in vivo. Glia 40:206-217
2. Banati RB, Newcombe J, Gunn RN, Cagnin A, Turkheimer F, Heppner F, Price G, Wegner F, Giovannoni G, Miller DH, Perkin GD, Smith T, Hewson AK, Bydder G, Kreutzberg GW, Jones T, Cuzner ML, Myers R (2000) The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 123(Pt 11):2321-2337
3. Biggio G, Concas A, Follesa P, Sanna E, Serra M (2007) Stress, ethanol, and neuroactive steroids. Pharmacol Ther 116:140-171
4. Briard E, Zoghbi SS, Imaizumi M, Gourley JP, Shetty HU, Hong J, Cropley V, Fujita M, Innis RB, Pike VW (2008) Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J Med Chem 51:17-30
5. Canat X, Carayon P, Bouaboula M, Cahard D, Shire D, Roque C, Le Fur G, Casellas P (1993) Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells. Life Sci 52:107-118
6. Chen MK, Guilarte TR (2008) Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacol Ther 118:1-17
7. Dolle F, Luus C, Reynolds A, Kassiou M (2009) Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography. Curr Med Chem 16:2899-2923
8. Ferrero P, Rocca P, Benna P, De Leo C, Montalenti E, Ravizza L, Bergamasco B (1992) An analysis of peripheral type benzodiazepine receptors on blood mononuclear cells during high dose steroid treatment of multiple sclerosis. Ital J Neurol Sci 13:685-691
9. Higgins GC, Beart PM, Shin YS, Chen MJ, Cheung NS, Nagley P (2010) Oxidative stress: emerging mitochondrial and cellular themes and variations in neuronal injury. J Alzheimers Dis 20(Suppl 2):S453-473
10. Kannan S, Balakrishnan B, Muzik O, Romero R, Chugani D (2009) Positron emission tomography imaging of neuroinflammation. J Child Neurol 24:1190-1199
11. Kreisl WC, Fujita M, Fujimura Y, Kimura N, Jenko KJ, Kannan P, Hong J, Morse CL, Zoghbi SS, Gladding RL, Jacobson S, Oh U, Pike VW, Innis RB (2010) Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission tomographic imaging of this inflammation biomarker. Neuroimage 49:2924-2932
12. Le Fur G, Guilloux F, Rufat P, Benavides J, Uzan A, Renault C, Dubroeucq MC, Gueremy C (1983) Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide. II. In vivo studies. Life Sci 32:1849-1856
13. Leschiner S, Weizman R, Shoukrun R, Veenman L, Gavish M (2000) Tissue-specific regulation of the peripheral benzodiazepine receptor by antidepressants and lithium. Neuropsychobiology 42:127-134
14. Mao P, Reddy PH (2010) Is multiple sclerosis a mitochondrial disease? Biochim Biophys Acta 1802:66-79
15. McEnery MW, Snowman AM, Trifiletti RR, Snyder SH (1992) Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A 89:3170-3174
16. Oh U, Fujita M, Ikonomidou VN, Evangelou IE, Matsuura E, Harberts E, Ohayon J, Pike VW, Zhang Y, Zoghbi SS, Innis RB, Jacobson S (2010) Translocator protein PET imaging for glial activation in multiple sclerosis. Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology
17. Owen DR, Gunn RN, Rabiner EA, Bennacef I, Fujita M, Kreisl WC, Innis RB, Pike VW, Reynolds R, Matthews PM, Parker CA (2011) Mixed-affinity binding in humans with 18-kDa translocator protein ligands. J Nucl Med 52:24-32
18. Papadopoulos V, Lecanu L (2009) Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma. Exp Neurol 219:53-57
19. Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversa JL, Bernassau JM, Drieu K (1997) Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids 62:21-28
20. Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapere JJ, Lindemann P, Norenberg MD, Nutt D, Weizman A, Zhang MR, Gavish M (2006) Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 27:402-409
21. Sahraian MA, Eshaghi A (2010) Role of MRI in diagnosis and treatment of multiple sclerosis. Clin Neurol Neurosurg 112:609-615
22. Skarica M, Eckstein C, Whartenby KA, Calabresi PA (2011) Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. J Neuroimmunol 235:70-76
23. Sospedra M, Martin R (2005) Immunology of multiple sclerosis. Annu Rev Immunol 23:683-747
24. Su KG, Banker G, Bourdette D, Forte M (2009) Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis. Curr Neurol Neurosci Rep 9:411-417
25. Veenman L, Papadopoulos V, Gavish M (2007) Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des 13:2385-2405
26. Veenman L, Shandalov Y, Gavish M (2008) VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis. J Bioenerg Biomembr 40:199-205
27. Wilms H, Claasen J, Rohl C, Sievers J, Deuschl G, Lucius R (2003) Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro. Neurobiol Dis 14:417-424
28. Witte ME, Bo L, Rodenburg RJ, Belien JA, Musters R, Hazes T, Wintjes LT, Smeitink JA, Geurts JJ, De Vries HE, van der Valk P, van Horssen J (2009) Enhanced number and activity of mitochondria in multiple sclerosis lesions. J Pathol 219:193-204
29. Woods MJ, Williams DC (1996) Multiple forms and locations for the peripheral-type benzodiazepine receptor. Biochem Pharmacol 52:1805-1814
30. Zhang R, Gascon R, Miller RG, Gelinas DF, Mass J, Hadlock K, Jin X, Reis J, Narvaez A, McGrath MS (2005) Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS). J Neuroimmunol 159:215-224