Initial evaluation in healthy humans of [ 18F]DPA-714, a potential PET biomarker for neuroinflammation

Nuclear Medicine and Biology

Volumn 39, Issue 4, 2012, Pages 570-578

  Arlicot, Nicolas ^a,b,c   Vercouillie, Johnny ^a,b   Ribeiro, Maria João ^a,b,c   Tauber, Clovis ^a,b   Venel, Yann ^c   Baulieu, Jean Louis ^a,b,c   Maia, Serge ^b,c   Corcia, Philippe ^a,b,c   Stabin, Michael G ^d   Reynolds, Aaron ^e   Kassiou, Michael ^e,f   Guilloteau, Denis ^a,b,c,g  

^a UNIVERSITÉ DE TOURS   (France)

^b CHRU de Tours   (France)

^c UNIVERSITY HOSPITAL OF TOURS   (France)

^d VANDERBILT UNIVERSITY   (United States)

^e UNIVERSITY OF SYDNEY   (Australia)

^f UNIVERSITY OF SYDNEY   (Australia)

^g CIC IT 806 Ultrasons et Radiopharmaceutiques   (France)

Author keywords

18F DPA 714; Biodistribution; Dosimetry; Neuroinflammation; PET; TSPO

Indexed keywords

N,N DIETHYL 2 [2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BRAIN REGION; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DOSE RESPONSE; DOSIMETRY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG STABILITY; DRUG UPTAKE; ENCEPHALITIS; FEMALE; FLOW KINETICS; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; IMAGE DISPLAY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PREDICTION; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; RADIOISOTOPE DIAGNOSIS; WHOLE BODY PET;

ADULT; AGED; ANIMALS; BIOLOGICAL MARKERS; BRAIN; CENTRAL NERVOUS SYSTEM DISEASES; FEMALE; FLUORINE RADIOISOTOPES; HEALTH; HUMANS; INFLAMMATION; KINETICS; MALE; MICE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RADIOMETRY; RECEPTORS, GABA;

EID: 84860337119     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2011.10.012     Document Type: Article

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