Evaluation of the PBR/TSPO radioligand 18 FDPA-714 in a rat model of focal cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 1, 2010, Pages 230-241

  Martín, Abraham ^a,b   Boisgard, Raphaël ^a,b   Thézé, Benoit ^a,b   Van Camp, Nadja ^a,b   Kuhnast, Bertrand ^b   Damont, Annelaure ^b   Kassiou, Michael ^c,d   Dollé, Frédéric ^b   Tavitian, Bertrand ^a,b  

^a INSERM   (France)

^b DIF   (France)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cerebral ischemia; Inflammatory reaction; Peripheral type benzodiazepine receptor; PET imaging; Transient middle cerebral artery occlusion; TSPO

Indexed keywords

BENZODIAZEPINE RECEPTOR; CARRIER PROTEIN; DPA 714; FLUORINE 18; N,N DIETHYL 2 [2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL 2 [2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE FLUORINE F 18; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG UPTAKE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MACROPHAGE; MALE; MICROGLIA; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ASTROCYTES; AUTORADIOGRAPHY; BRAIN ISCHEMIA; CARRIER PROTEINS; CELL COUNT; DATA INTERPRETATION, STATISTICAL; FLUORINE RADIOISOTOPES; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICROGLIA; MODELS, STATISTICAL; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STROKE;

EID: 73949087909     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.205     Document Type: Article

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