Metabolism and quantification of [18F]DPA-714, a new TSPO positron emission tomography radioligand

Drug Metabolism and Disposition

Volumn 41, Issue 1, 2013, Pages 122-131

  Peyronneau, Marie Anne ^a   Saba, Wadad ^a   Goutal, Sébastien ^a   Damont, Annelaure ^a   Dollé, Frédéric ^a   Kassiou, Michael ^b   Bottlaender, Michel ^a   Valette, Héric ^a  

^a DIF   (France)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DPA 714; FLUORINE 18; N,N DIETHYL 2 (2 (4 (FLUOROETHOXY)PHENYL) 5,7 DIMETHYLPYRAZOLO[1,5A]PYRIMIDIN 3 YL)ACETAMIDE F 18; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG RETENTION; DRUG STRUCTURE; DRUG UPTAKE; GALLBLADDER; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIVER; MALE; MASS SPECTROMETRY; METABOLITE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOISOTOPE DISTRIBUTION; RAT; REACTION TIME; SOLID PHASE EXTRACTION; WHOLE BODY TOMOGRAPHY;

ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; FLUORINE RADIOISOTOPES; HUMANS; MALE; MICROSOMES, LIVER; PAPIO; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SOLID PHASE EXTRACTION; SPECTROPHOTOMETRY, ULTRAVIOLET;

ANIMALIA; PAPIO; RATTUS;

EID: 84871602840     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.046342     Document Type: Article

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