11C-DPA-713: A novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation

Journal of Nuclear Medicine

Volumn 48, Issue 4, 2007, Pages 573-581

  Boutin, Hervé ^a,b,c   Chauveau, Fabien ^a,b   Thominiaux, Cyrille ^a   Grégoire, Marie Claude ^d,e   James, Michelle L ^e   Trebossen, Régine ^a   Hantraye, Philippe ^d   Dollé, Frédéric ^a   Tavitian, Bertrand ^a,b,h   Kassiou, Michael ^f,g  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^b INSERM   (France)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d DIF   (France)

^e AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^f UNIVERSITY OF SYDNEY   (Australia)

^g UNIVERSITY OF SYDNEY   (Australia)

^h Laboratoire d'Imagerie Moléculaire Expérimentale   (France)

Author keywords

Gliosis; Inflammation; Peripheral benzodiazepine receptor; PET; PK11195

Indexed keywords

ACETAMIDE DERIVATIVE; BENZODIAZEPINE RECEPTOR; CARBON 11; DPA 713; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N,N DIETHYL 2 [2 (4 METHOXYPHENYL) 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; RADIOLIGAND; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CARBON; ISOQUINOLINE DERIVATIVE; N,N DIETHYL 2 (2 (4 METHOXYPHENYL) 5,7 DIMETHYL PYRAZOLO(1,5 A)PYRIMIDIN 3 YL) ACETAMIDE; N,N-DIETHYL-2-(2-(4-METHOXYPHENYL)-5,7-DIMETHYL-PYRAZOLO(1,5-A)PYRIMIDIN-3-YL)-ACETAMIDE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DIAGNOSTIC IMAGING; DRUG BINDING; DRUG UPTAKE; HISTOPATHOLOGY; IMAGE ANALYSIS; IN VIVO STUDY; MICROGLIA; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; CHEMISTRY; HUMAN; INFLAMMATION; MALE; METABOLISM; METHODOLOGY; NERVE CELL; PATHOLOGY; WISTAR RAT;

ACETAMIDES; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; HUMANS; INFLAMMATION; ISOQUINOLINES; MALE; NEURONS; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 34248529814     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.106.036764     Document Type: Article

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