메뉴 건너뛰기




Volumn 77, Issue , 2015, Pages 229-249

Regeneration and repair of the exocrine pancreas

Author keywords

Acinar cell; Caerulein; Cerulein; Differentiation; Inflammation; Metaplasia; Pancreatitis

Indexed keywords

CERULETIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR;

EID: 84922801415     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-021014-071727     Document Type: Article
Times cited : (147)

References (121)
  • 1
    • 43449124920 scopus 로고    scopus 로고
    • Acute pancreatitis
    • SteinbergWM. 2006. Acute pancreatitis. See Ref. 121, pp. 1241-69
    • (2006) See Ref. , vol.121 , pp. 1241-1269
    • Steinberg, W.M.1
  • 2
    • 79951648873 scopus 로고    scopus 로고
    • Pancreas organogenesis: From bud to plexus to gland
    • Pan FC, Wright C. 2011. Pancreas organogenesis: from bud to plexus to gland. Dev. Dyn. 240:530-65
    • (2011) Dev. Dyn. , vol.240 , pp. 530-565
    • Pan, F.C.1    Wright, C.2
  • 3
    • 84885792555 scopus 로고    scopus 로고
    • Pancreas organogenesis: From lineage determination to morphogenesis
    • Shih HP, Wang A, Sander M. 2013. Pancreas organogenesis: from lineage determination to morphogenesis. Annu. Rev. Cell Dev. Biol. 29:81-105
    • (2013) Annu. Rev. Cell Dev. Biol. , vol.29 , pp. 81-105
    • Shih, H.P.1    Wang, A.2    Sander, M.3
  • 4
  • 5
    • 84873111871 scopus 로고    scopus 로고
    • Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
    • Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, et al. 2013. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development 140:751-64
    • (2013) Development , vol.140 , pp. 751-764
    • Pan, F.C.1    Bankaitis, E.D.2    Boyer, D.3    Xu, X.4    Van De Casteele, M.5
  • 6
    • 35348985382 scopus 로고    scopus 로고
    • Early pancreatic development requires the vertebrate Suppressor ofHairless (RBPJ) in the PTF1 bHLHcomplex
    • Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ. 2007. Early pancreatic development requires the vertebrate Suppressor ofHairless (RBPJ) in the PTF1 bHLHcomplex. Genes Dev. 21:2629-43
    • (2007) Genes Dev. , vol.21 , pp. 2629-2643
    • Masui, T.1    Long, Q.2    Beres, T.M.3    Magnuson, M.A.4    Macdonald, R.J.5
  • 7
    • 79951539242 scopus 로고    scopus 로고
    • Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    • Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, et al. 2011. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 138:653-65
    • (2011) Development , vol.138 , pp. 653-665
    • Kopp, J.L.1    Dubois, C.L.2    Schaffer, A.E.3    Hao, E.4    Shih, H.P.5
  • 8
    • 71649092364 scopus 로고    scopus 로고
    • Pancreatic exocrine duct cells give rise to insulin-producing βcells during embryogenesis but not after birth
    • Solar M, Cardalda C, Houbracken I, Martin M, Maestro MA, et al. 2009. Pancreatic exocrine duct cells give rise to insulin-producing βcells during embryogenesis but not after birth. Dev. Cell 17:849-60
    • (2009) Dev. Cell , vol.17 , pp. 849-860
    • Solar, M.1    Cardalda, C.2    Houbracken, I.3    Martin, M.4    Maestro, M.A.5
  • 10
    • 77950681696 scopus 로고    scopus 로고
    • Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas
    • Kopinke D,Murtaugh LC. 2010. Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev. Biol. 10:38
    • (2010) BMC Dev. Biol. , vol.10 , pp. 38
    • Kopinke, D.1    Murtaugh, L.C.2
  • 11
    • 80052383141 scopus 로고    scopus 로고
    • Chronic pancreatitis
    • Forsmark CE. 2006. Chronic pancreatitis. See Ref. 121, pp. 1271-1308
    • (2006) See Ref. , vol.121 , pp. 1271-1308
    • Forsmark, C.E.1
  • 12
    • 68849105055 scopus 로고    scopus 로고
    • Inflammation and pancreatic cancer: An evidence-based review
    • Greer JB, Whitcomb DC. 2009. Inflammation and pancreatic cancer: an evidence-based review. Curr. Opin. Pharmacol. 9:411-18
    • (2009) Curr. Opin. Pharmacol. , vol.9 , pp. 411-418
    • Greer, J.B.1    Whitcomb, D.C.2
  • 13
    • 84876813879 scopus 로고    scopus 로고
    • Genetic risk factors for pancreatic disorders
    • Whitcomb DC. 2013. Genetic risk factors for pancreatic disorders. Gastroenterology 144:1292-302
    • (2013) Gastroenterology , vol.144 , pp. 1292-1302
    • Whitcomb, D.C.1
  • 14
    • 81855228093 scopus 로고    scopus 로고
    • Intra-Acinar trypsinogen activationmediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis
    • Dawra R, SahRP, Dudeja V, RishiL,Talukdar R, et al. 2011. Intra-Acinar trypsinogen activationmediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis. Gastroenterology 141:2210-17.e2
    • (2011) Gastroenterology , vol.141
    • Dawra, R.1    Sah, R.P.2    Dudeja, V.3    Rishi, L.4    Talukdar, R.5
  • 15
    • 20444479721 scopus 로고    scopus 로고
    • Protease inhibitors in acute pancreatitis: Lessons from the bench and failed clinical trials
    • Singh VP, Chari ST. 2005. Protease inhibitors in acute pancreatitis: lessons from the bench and failed clinical trials. Gastroenterology 128:2172-74
    • (2005) Gastroenterology , vol.128 , pp. 2172-2174
    • Singh, V.P.1    Chari, S.T.2
  • 16
    • 84878953735 scopus 로고    scopus 로고
    • The role of protein synthesis and digestive enzymes in acinar cell injury
    • Logsdon CD, Ji B. 2013. The role of protein synthesis and digestive enzymes in acinar cell injury. Nat. Rev. Gastroenterol. Hepatol. 10:362-70
    • (2013) Nat. Rev. Gastroenterol. Hepatol. , vol.10 , pp. 362-370
    • Logsdon, C.D.1    Ji, B.2
  • 17
    • 0030750624 scopus 로고    scopus 로고
    • Morphology of the exocrine pancreas related to pancreatitis
    • Bockman DE. 1997. Morphology of the exocrine pancreas related to pancreatitis. Microsc. Res. Tech. 37:509-19
    • (1997) Microsc. Res. Tech. , vol.37 , pp. 509-519
    • Bockman, D.E.1
  • 18
    • 0019987348 scopus 로고
    • Origin of tubular complexes in human chronic pancreatitis
    • Bockman DE, Boydston WR, Anderson MC. 1982. Origin of tubular complexes in human chronic pancreatitis. Am. J. Surg. 144:243-49
    • (1982) Am. J. Surg. , vol.144 , pp. 243-249
    • Bockman, D.E.1    Boydston, W.R.2    Anderson, M.C.3
  • 19
    • 0024509369 scopus 로고
    • Histochemical and ultrastructural characteristics of tubular complexes in human acute pancreatitis
    • Willemer S, Adler G. 1989. Histochemical and ultrastructural characteristics of tubular complexes in human acute pancreatitis. Dig. Dis. Sci. 34:46-55
    • (1989) Dig. Dis. Sci. , vol.34 , pp. 46-55
    • Willemer, S.1    Adler, G.2
  • 20
    • 0032980230 scopus 로고    scopus 로고
    • Alteration of fibroblast growth factor and receptor expression after acute pancreatitis in humans
    • Ebert M, Yokoyama M, Ishiwata T, Friess H, Buchler MW, et al. 1999. Alteration of fibroblast growth factor and receptor expression after acute pancreatitis in humans. Pancreas 18:240-46
    • (1999) Pancreas , vol.18 , pp. 240-246
    • Ebert, M.1    Yokoyama, M.2    Ishiwata, T.3    Friess, H.4    Buchler, M.W.5
  • 21
    • 0036786305 scopus 로고    scopus 로고
    • Pancreatic stellate cells contribute to regeneration early after acute necrotising pancreatitis in humans
    • Zimmermann A, Gloor B, Kappeler A, Uhl W, Friess H, Buchler MW. 2002. Pancreatic stellate cells contribute to regeneration early after acute necrotising pancreatitis in humans. Gut 51:574-78
    • (2002) Gut , vol.51 , pp. 574-578
    • Zimmermann, A.1    Gloor, B.2    Kappeler, A.3    Uhl, W.4    Friess, H.5    Buchler, M.W.6
  • 22
    • 84876788888 scopus 로고    scopus 로고
    • Models of acute and chronic pancreatitis
    • Lerch MM, Gorelick FS. 2013. Models of acute and chronic pancreatitis. Gastroenterology 144:1180-93
    • (2013) Gastroenterology , vol.144 , pp. 1180-1193
    • Lerch, M.M.1    Gorelick, F.S.2
  • 24
    • 0033795691 scopus 로고    scopus 로고
    • Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    • Halangk W, Lerch MM, Brandt-Nedelev B, RothW, Ruthenbuerger M, et al. 2000. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J. Clin. Investig. 106:773-81
    • (2000) J. Clin. Investig. , vol.106 , pp. 773-781
    • Halangk, W.1    Lerch, M.M.2    Brandt-Nedelev, B.3    Roth, W.4    Ruthenbuerger, M.5
  • 28
    • 76649105065 scopus 로고    scopus 로고
    • Catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    • Morris JP IV, Cano DA, Sekine S, Wang SC, Hebrok M. 2010. β-Catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J. Clin. Investig. 120:508-20
    • (2010) J. Clin. Investig. , vol.120 , pp. 508-520
    • Morris, J.P.1    Cano, D.A.2    Sekine, S.3    Wang, S.C.4    Hebrok, M.5
  • 29
    • 2342434472 scopus 로고    scopus 로고
    • Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-κB activation
    • Zhong B, Zhou Q, Toivola DM, Tao GZ, Resurreccion EZ, Omary MB. 2004. Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-κB activation. J. Cell Sci. 117:1709-19
    • (2004) J. Cell Sci. , vol.117 , pp. 1709-1719
    • Zhong, B.1    Zhou, Q.2    Toivola, D.M.3    Tao, G.Z.4    Resurreccion, E.Z.5    Omary, M.B.6
  • 30
    • 67649313759 scopus 로고    scopus 로고
    • Notch and Kras in pancreatic cancer: At the crossroads of mutation, differentiation and signaling
    • De La O J-P, Murtaugh LC. 2009. Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling. Cell Cycle 8:1860-64
    • (2009) Cell Cycle , vol.8 , pp. 1860-1864
    • De La, O.J.-P.1    Murtaugh, L.C.2
  • 31
    • 48549095907 scopus 로고    scopus 로고
    • Hedgehog signaling is required for effective regeneration of exocrine pancreas
    • Fendrich V, Esni F, GarayMV, Feldmann G, Habbe N, et al. 2008. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology 135:621-31
    • (2008) Gastroenterology , vol.135 , pp. 621-631
    • Fendrich, V.1    Esni, F.2    Garay, M.V.3    Feldmann, G.4    Habbe, N.5
  • 32
    • 0034090675 scopus 로고    scopus 로고
    • Repetitive acute pancreatic injury in the mouse induces procollagen α1I expression colocalized to pancreatic stellate cells
    • Neuschwander-Tetri BA, Bridle KR, Wells LD,Marcu M, Ramm GA. 2000. Repetitive acute pancreatic injury in the mouse induces procollagen α1I expression colocalized to pancreatic stellate cells. Lab. Investig. 80:143-50
    • (2000) Lab. Investig. , vol.80 , pp. 143-150
    • Neuschwander-Tetri, B.A.1    Bridle, K.R.2    Wells, L.D.3    Marcu, M.4    Ramm, G.A.5
  • 33
    • 0023151584 scopus 로고
    • Ultrastructure of the rat pancreas after experimental duct ligation i the role of apoptosis and intraepithelial macrophages in acinar cell deletion
    • Walker NI. 1987. Ultrastructure of the rat pancreas after experimental duct ligation. I. The role of apoptosis and intraepithelial macrophages in acinar cell deletion. Am. J. Pathol. 126:439-51
    • (1987) Am. J. Pathol. , vol.126 , pp. 439-451
    • Walker, N.I.1
  • 36
    • 0020636495 scopus 로고
    • Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
    • Bonner-Weir S, Trent DF,Weir GC. 1983. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J. Clin. Investig. 71:1544-53
    • (1983) J. Clin. Investig. , vol.71 , pp. 1544-1553
    • Bonner-Weir, S.1    Trent, D.F.2    Weir, G.C.3
  • 37
    • 19044373371 scopus 로고    scopus 로고
    • Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation
    • Watanabe H, Saito H, Rychahou PG, Uchida T, Evers BM. 2005. Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation. Gastroenterology 128:1391-404
    • (2005) Gastroenterology , vol.128 , pp. 1391-1404
    • Watanabe, H.1    Saito, H.2    Rychahou, P.G.3    Uchida, T.4    Evers, B.M.5
  • 38
    • 66649128739 scopus 로고    scopus 로고
    • Adaptive β-cell proliferation is severely restricted with advanced age
    • Rankin MM, Kushner JA. 2009. Adaptive β-cell proliferation is severely restricted with advanced age. Diabetes 58:1365-72
    • (2009) Diabetes , vol.58 , pp. 1365-1372
    • Rankin, M.M.1    Kushner, J.A.2
  • 39
    • 27644585280 scopus 로고    scopus 로고
    • Pancreatic regeneration after near-total pancreatectomy in children with nesidioblastosis
    • Berrocal T, Luque AA, Pinilla I, Lassaletta L. 2005. Pancreatic regeneration after near-total pancreatectomy in children with nesidioblastosis. Pediatr. Radiol. 35:1066-70
    • (2005) Pediatr. Radiol. , vol.35 , pp. 1066-1070
    • Berrocal, T.1    Luque, A.A.2    Pinilla, I.3    Lassaletta, L.4
  • 40
    • 38449086256 scopus 로고    scopus 로고
    • Partial pancreatectomy in adult humans does not provoke β-cell regeneration
    • Menge BA, Tannapfel A, Belyaev O, Drescher R, Muller C, et al. 2008. Partial pancreatectomy in adult humans does not provoke β-cell regeneration. Diabetes 57:142-49
    • (2008) Diabetes , vol.57 , pp. 142-149
    • Menge, B.A.1    Tannapfel, A.2    Belyaev, O.3    Drescher, R.4    Muller, C.5
  • 41
    • 0032830292 scopus 로고    scopus 로고
    • Pancreas regeneration after resection: Does it occur in humans?
    • Tsiotos GG, Barry MK, Johnson CD, Sarr MG. 1999. Pancreas regeneration after resection: Does it occur in humans? Pancreas 19:310-13
    • (1999) Pancreas , vol.19 , pp. 310-313
    • Tsiotos, G.G.1    Barry, M.K.2    Johnson, C.D.3    Sarr, M.G.4
  • 42
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreaticβ-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA. 2004. Adult pancreaticβ-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 43
    • 34848887156 scopus 로고    scopus 로고
    • Recovery from diabetes in mice by βcell regeneration
    • Nir T,Melton DA, Dor Y. 2007. Recovery from diabetes in mice by βcell regeneration. J. Clin. Investig. 117:2553-61
    • (2007) J. Clin. Investig. , vol.117 , pp. 2553-2561
    • Nir, T.1    Melton, D.A.2    Dor, Y.3
  • 44
    • 36549077062 scopus 로고    scopus 로고
    • In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia
    • Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, et al. 2007. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology 133:1999-2009
    • (2007) Gastroenterology , vol.133 , pp. 1999-2009
    • Strobel, O.1    Dor, Y.2    Alsina, J.3    Stirman, A.4    Lauwers, G.5
  • 45
    • 34147190365 scopus 로고    scopus 로고
    • Preexisting pancreatic acinar cells contribute to acinar cell, but not islet βcell, regeneration
    • Desai BM, Oliver-Krasinski J, De Leon DD, Farzad C, Hong N, et al. 2007. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet βcell, regeneration. J. Clin. Investig. 117:971-77
    • (2007) J. Clin. Investig. , vol.117 , pp. 971-977
    • Desai, B.M.1    Oliver-Krasinski, J.2    De Leon, D.D.3    Farzad, C.4    Hong, N.5
  • 46
    • 84863427641 scopus 로고    scopus 로고
    • Catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice
    • Keefe MD, Wang H, De La O J-P, Khan A, Firpo MA, Murtaugh LC. 2012. β-Catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis. Models Mech. 5:503-14
    • (2012) Dis. Models Mech. , vol.5 , pp. 503-514
    • Keefe, M.D.1    Wang, H.2    De La O, J.-P.3    Khan, A.4    Firpo, M.A.5    Murtaugh, L.C.6
  • 47
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
    • Thorel F, Nepote V, Avril I, Kohno K, Desgraz R, et al. 2010. Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss. Nature 464:1149-54
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Nepote, V.2    Avril, I.3    Kohno, K.4    Desgraz, R.5
  • 48
    • 80053603426 scopus 로고    scopus 로고
    • Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice
    • Criscimanna A, Speicher JA, Houshmand G, Shiota C, Prasadan K, et al. 2011. Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice. Gastroenterology 141:1451-62.e6
    • (2011) Gastroenterology , vol.141
    • Criscimanna, A.1    Speicher, J.A.2    Houshmand, G.3    Shiota, C.4    Prasadan, K.5
  • 49
    • 0037309879 scopus 로고    scopus 로고
    • Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas ofmice deficient for the Cx32 gene
    • Frossard JL, Rubbia-Brandt L, Wallig MA, BenathanM,Ott T, et al. 2003. Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas ofmice deficient for the Cx32 gene. Gastroenterology 124:481-93
    • (2003) Gastroenterology , vol.124 , pp. 481-493
    • Frossard, J.L.1    Rubbia-Brandt, L.2    Wallig, M.A.3    Benathan, M.4    Ott, T.5
  • 50
    • 23244433449 scopus 로고    scopus 로고
    • A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice
    • Dimagno MJ, Lee SH, Hao Y, Zhou SY, McKenna BJ, Owyang C. 2005. A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice. Gastroenterology 129:665-81
    • (2005) Gastroenterology , vol.129 , pp. 665-681
    • Dimagno, M.J.1    Lee, S.H.2    Hao, Y.3    Zhou, S.Y.4    McKenna, B.J.5    Owyang, C.6
  • 51
    • 33845661591 scopus 로고    scopus 로고
    • Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis
    • Cano DA, Sekine S, Hebrok M. 2006. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology 131:1856-69
    • (2006) Gastroenterology , vol.131 , pp. 1856-1869
    • Cano, D.A.1    Sekine, S.2    Hebrok, M.3
  • 52
    • 0036266409 scopus 로고    scopus 로고
    • Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas
    • Crawford HC, Scoggins CR, Washington MK, Matrisian LM, Leach SD. 2002. Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J. Clin. Investig. 109:1437-44
    • (2002) J. Clin. Investig. , vol.109 , pp. 1437-1444
    • Crawford, H.C.1    Scoggins, C.R.2    Washington, M.K.3    Matrisian, L.M.4    Leach, S.D.5
  • 53
    • 84879878335 scopus 로고    scopus 로고
    • Pancreas-specific Cre driver lines and considerations for their prudent use
    • Magnuson MA, Osipovich AB. 2013. Pancreas-specific Cre driver lines and considerations for their prudent use. Cell Metab. 18:9-20
    • (2013) Cell Metab. , vol.18 , pp. 9-20
    • Magnuson, M.A.1    Osipovich, A.B.2
  • 55
    • 24944572259 scopus 로고    scopus 로고
    • Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
    • Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, et al. 2005. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8:185-95
    • (2005) Cancer Cell , vol.8 , pp. 185-195
    • Stanger, B.Z.1    Stiles, B.2    Lauwers, G.Y.3    Bardeesy, N.4    Mendoza, M.5
  • 56
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    • Guerra C, Schuhmacher AJ, Canamero M, Grippo PJ, Verdaguer L, et al. 2007. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11:291-302
    • (2007) Cancer Cell , vol.11 , pp. 291-302
    • Guerra, C.1    Schuhmacher, A.J.2    Canamero, M.3    Grippo, P.J.4    Verdaguer, L.5
  • 58
    • 0030726979 scopus 로고    scopus 로고
    • Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis
    • Grady T, Liang P, Ernst SA, Logsdon CD. 1997. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Gastroenterology 113:1966-75
    • (1997) Gastroenterology , vol.113 , pp. 1966-1975
    • Grady, T.1    Liang, P.2    Ernst, S.A.3    Logsdon, C.D.4
  • 59
    • 0030923560 scopus 로고    scopus 로고
    • Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-α Role in regulating cell death and pancreatitis
    • Gukovskaya AS, Gukovsky I, Zaninovic V, Song M, Sandoval D, et al. 1997. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-α. Role in regulating cell death and pancreatitis. J. Clin. Investig. 100:1853-62
    • (1997) J. Clin. Investig. , vol.100 , pp. 1853-1862
    • Gukovskaya, A.S.1    Gukovsky, I.2    Zaninovic, V.3    Song, M.4    Sandoval, D.5
  • 60
    • 33845998896 scopus 로고    scopus 로고
    • The pancreatic stellate cell: A star on the rise in pancreatic diseases
    • Omary MB, Lugea A, Lowe AW, Pandol SJ. 2007. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J. Clin. Investig. 117:50-59
    • (2007) J. Clin. Investig. , vol.117 , pp. 50-59
    • Omary, M.B.1    Lugea, A.2    Lowe, A.W.3    Pandol, S.J.4
  • 61
    • 0031842971 scopus 로고    scopus 로고
    • Periacinar stellate shaped cells in rat pancreas: Identification, isolation, and culture
    • Apte MV,Haber PS, Applegate TL, Norton ID, McCaughan GW, et al. 1998. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43:128-33
    • (1998) Gut , vol.43 , pp. 128-133
    • Apte, M.V.1    Haber, P.S.2    Applegate, T.L.3    Norton, I.D.4    McCaughan, G.W.5
  • 62
  • 63
    • 84866692545 scopus 로고    scopus 로고
    • Deactivation of hepatic stellate cells during liver fibrosis resolution in mice
    • Troeger JS, Mederacke I, Gwak GY, Dapito DH, Mu X, et al. 2012. Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. Gastroenterology 143:1073-83.e22
    • (2012) Gastroenterology , vol.143
    • Troeger, J.S.1    Mederacke, I.2    Gwak, G.Y.3    Dapito, D.H.4    Mu, X.5
  • 64
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinomaassociated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Ö zdemirBC, Pentcheva-HoangT,Carstens JL,ZhengX,WuC-C, et al. 2014.Depletion of carcinomaassociated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25:719-34
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Ozdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3    Zheng, X.4    Wu, C.-C.5
  • 65
    • 84902435628 scopus 로고    scopus 로고
    • Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    • Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, et al. 2014. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25:735-47
    • (2014) Cancer Cell , vol.25 , pp. 735-747
    • Rhim, A.D.1    Oberstein, P.E.2    Thomas, D.H.3    Mirek, E.T.4    Palermo, C.F.5
  • 66
    • 84876796439 scopus 로고    scopus 로고
    • Inflammation, autophagy, and obesity: Common features in the pathogenesis of pancreatitis and pancreatic cancer
    • Gukovsky I, Li N, Todoric J, Gukovskaya A, Karin M. 2013. Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology 144:1199-209.e4
    • (2013) Gastroenterology , vol.144
    • Gukovsky, I.1    Li, N.2    Todoric, J.3    Gukovskaya, A.4    Karin, M.5
  • 67
    • 84876807399 scopus 로고    scopus 로고
    • Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma
    • Zheng L, Xue J, Jaffee EM, Habtezion A. 2013. Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma. Gastroenterology 144:1230-40
    • (2013) Gastroenterology , vol.144 , pp. 1230-1240
    • Zheng, L.1    Xue, J.2    Jaffee, E.M.3    Habtezion, A.4
  • 68
    • 84873408281 scopus 로고    scopus 로고
    • Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice
    • Sendler M, Dummer A, Weiss FU, Kruger B, Wartmann T, et al. 2013. Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Gut 62:430-39
    • (2013) Gut , vol.62 , pp. 430-439
    • Sendler, M.1    Dummer, A.2    Weiss, F.U.3    Kruger, B.4    Wartmann, T.5
  • 69
    • 80053588704 scopus 로고    scopus 로고
    • Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis
    • TreiberM,Neuh ofer P, AnetsbergerE,EinwächterH,LesinaM, et al. 2011. Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis. Gastroenterology 141:1473-85.e7
    • (2011) Gastroenterology , vol.141
    • Treiber, M.1    Neuhofer, P.2    Anetsberger, E.3    Einwächter, H.4    Lesina, M.5
  • 70
    • 84904258511 scopus 로고    scopus 로고
    • Aberrant innate immune activation following tissue injury impairs pancreatic regeneration
    • Folias AE, Penaranda C, Su AL, Bluestone JA, Hebrok M. 2014. Aberrant innate immune activation following tissue injury impairs pancreatic regeneration. PLOS ONE 9:e102125
    • (2014) PLOS ONE , vol.9 , pp. e102125
    • Folias, A.E.1    Penaranda, C.2    Su, A.L.3    Bluestone, J.A.4    Hebrok, M.5
  • 73
    • 0030830283 scopus 로고    scopus 로고
    • Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis
    • Denham W, Yang J, Fink G, Denham D, Carter G, et al. 1997. Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. Gastroenterology 113:1741-46
    • (1997) Gastroenterology , vol.113 , pp. 1741-1746
    • Denham, W.1    Yang, J.2    Fink, G.3    Denham, D.4    Carter, G.5
  • 74
    • 84884236200 scopus 로고    scopus 로고
    • Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs
    • Liou GY, Doppler H, Necela B, Krishna M, Crawford HC, et al. 2013. Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs. J. Cell Biol. 202:563-77
    • (2013) J. Cell Biol. , vol.202 , pp. 563-577
    • Liou, G.Y.1    Doppler, H.2    Necela, B.3    Krishna, M.4    Crawford, H.C.5
  • 75
    • 84871299072 scopus 로고    scopus 로고
    • Nuclear factor-κB in pancreatitis: Jack-of-All-trades, but which one is more important?
    • Gukovsky I, Gukovskaya A. 2013. Nuclear factor-κB in pancreatitis: jack-of-All-trades, but which one is more important? Gastroenterology 144:26-29
    • (2013) Gastroenterology , vol.144 , pp. 26-29
    • Gukovsky, I.1    Gukovskaya, A.2
  • 76
    • 84871272183 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice
    • Huang H, Liu Y, Daniluk J, Gaiser S, Chu J, et al. 2013. Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice. Gastroenterology 144:202-10
    • (2013) Gastroenterology , vol.144 , pp. 202-210
    • Huang, H.1    Liu, Y.2    Daniluk, J.3    Gaiser, S.4    Chu, J.5
  • 77
    • 34249879045 scopus 로고    scopus 로고
    • Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-Associated cell death following cerulein pancreatitis
    • Algul H, Treiber M, Lesina M, Nakhai H, Saur D, et al. 2007. Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-Associated cell death following cerulein pancreatitis. J. Clin. Investig. 117:1490-501
    • (2007) J. Clin. Investig. , vol.117 , pp. 1490-1501
    • Algul, H.1    Treiber, M.2    Lesina, M.3    Nakhai, H.4    Saur, D.5
  • 78
    • 84871282951 scopus 로고    scopus 로고
    • Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A
    • Neuhofer P, Liang S, Einwachter H, Schwerdtfeger C, Wartmann T, et al. 2013. Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A. Gastroenterology 144:192-201
    • (2013) Gastroenterology , vol.144 , pp. 192-201
    • Neuhofer, P.1    Liang, S.2    Einwachter, H.3    Schwerdtfeger, C.4    Wartmann, T.5
  • 79
    • 84874606609 scopus 로고    scopus 로고
    • IL-6 trans-signaling promotes pancreatitisassociated lung injury and lethality
    • ZhangH,Neuhofer P, SongL,Rabe B,LesinaM, et al. 2013. IL-6 trans-signaling promotes pancreatitisassociated lung injury and lethality. J. Clin. Investig. 123:1019-31
    • (2013) J. Clin. Investig. , vol.123 , pp. 1019-1031
    • Zhang, H.1    Neuhofer, P.2    Song, L.3    Rabe, B.4    Lesina, M.5
  • 80
    • 0036038907 scopus 로고    scopus 로고
    • Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice
    • Cuzzocrea S, Mazzon E, Dugo L, Centorrino T, Ciccolo A, et al. 2002. Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice. Cytokine 18:274-85
    • (2002) Cytokine , vol.18 , pp. 274-285
    • Cuzzocrea, S.1    Mazzon, E.2    Dugo, L.3    Centorrino, T.4    Ciccolo, A.5
  • 81
    • 33645083973 scopus 로고    scopus 로고
    • Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo
    • Chao KC, Chao KF, Chuang CC, Liu SH. 2006. Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo. Br. J. Surg. 93:332-38
    • (2006) Br. J. Surg. , vol.93 , pp. 332-338
    • Chao, K.C.1    Chao, K.F.2    Chuang, C.C.3    Liu, S.H.4
  • 82
    • 84869192369 scopus 로고    scopus 로고
    • Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction
    • Shigekawa M, Hikita H, Kodama T, Shimizu S, Li W, et al. 2012. Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction. Am. J. Pathol. 181:2105-13
    • (2012) Am. J. Pathol. , vol.181 , pp. 2105-2113
    • Shigekawa, M.1    Hikita, H.2    Kodama, T.3    Shimizu, S.4    Li, W.5
  • 83
    • 84886286597 scopus 로고    scopus 로고
    • Notch signaling in the pancreas: Patterning and cell fate specification
    • Afelik S, Jensen J. 2013. Notch signaling in the pancreas: patterning and cell fate specification. WIREs Dev. Biol. 2:531-44
    • (2013) WIREs Dev. Biol. , vol.2 , pp. 531-544
    • Afelik, S.1    Jensen, J.2
  • 85
    • 84910156818 scopus 로고    scopus 로고
    • The contrasting roles of primary cilia and cytonemes in Hh signaling
    • Kornberg TB. 2014. The contrasting roles of primary cilia and cytonemes in Hh signaling. Dev. Biol. 394:1-5
    • (2014) Dev. Biol. , vol.394 , pp. 1-5
    • Kornberg, T.B.1
  • 86
    • 84878282156 scopus 로고    scopus 로고
    • Hippo signaling regulates differentiation and maintenance in the exocrine pancreas
    • GaoT,ZhouD,YangC, Singh T, Penzo-Mendez A, et al. 2013. Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology 144:1543-53.e1
    • (2013) Gastroenterology , vol.144
    • Gao, T.1    Zhou, D.2    Yang, C.3    Singh, T.4    Penzo-Mendez, A.5
  • 88
    • 77954636626 scopus 로고    scopus 로고
    • Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling
    • Blaine SA, Ray KC, Anunobi R, Gannon MA, Washington MK, Means AL. 2010. Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling. Development 137:2289-96
    • (2010) Development , vol.137 , pp. 2289-2296
    • Blaine, S.A.1    Ray, K.C.2    Anunobi, R.3    Gannon, M.A.4    Washington, M.K.5    Means, A.L.6
  • 90
    • 28044449357 scopus 로고    scopus 로고
    • Catenin is essential for pancreatic acinar but not islet development
    • Murtaugh LC, Law AC, Dor Y, Melton DA. 2005. β-Catenin is essential for pancreatic acinar but not islet development. Development 132:4663-74
    • (2005) Development , vol.132 , pp. 4663-4674
    • Murtaugh, L.C.1    Law, A.C.2    Dor, Y.3    Melton, D.A.4
  • 91
    • 33846807059 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling is required for development of the exocrine pancreas
    • Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, et al. 2007. Wnt/β-catenin signaling is required for development of the exocrine pancreas. BMC Dev. Biol. 7:4
    • (2007) BMC Dev. Biol. , vol.7 , pp. 4
    • Wells, J.M.1    Esni, F.2    Boivin, G.P.3    Aronow, B.J.4    Stuart, W.5
  • 92
    • 34548167006 scopus 로고    scopus 로고
    • Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas
    • Strom A, Bonal C, Ashery-Padan R, Hashimoto N, Campos ML, et al. 2007. Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134:2719-25
    • (2007) Development , vol.134 , pp. 2719-2725
    • Strom, A.1    Bonal, C.2    Ashery-Padan, R.3    Hashimoto, N.4    Campos, M.L.5
  • 94
    • 84862171364 scopus 로고    scopus 로고
    • Themany faces and functions ofβ-catenin
    • ValentaT,Hausmann G, Basler K. 2012. Themany faces and functions ofβ-catenin. EMBO J. 31:2714-36
    • (2012) EMBO J. , vol.31 , pp. 2714-2736
    • Valenta, T.1    Hausmann, G.2    Basler, K.3
  • 95
    • 77749246063 scopus 로고    scopus 로고
    • Macrophage Wnt7b is critical for kidney repair and regeneration
    • Lin SL, Li B, Rao S, Yeo EJ, Hudson TE, et al. 2010. Macrophage Wnt7b is critical for kidney repair and regeneration. PNAS 107:4194-99
    • (2010) PNAS , vol.107 , pp. 4194-4199
    • Lin, S.L.1    Li, B.2    Rao, S.3    Yeo, E.J.4    Hudson, T.E.5
  • 96
    • 84905483275 scopus 로고    scopus 로고
    • The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell-formation and acinar differentiation during pancreatic organogenesis
    • Hale MA, Swift GH,Hoang CQ,DeeringTG, MasuiT, et al. 2014. The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell-formation and acinar differentiation during pancreatic organogenesis. Development 141:3123-33
    • (2014) Development , vol.141 , pp. 3123-3133
    • Hale, M.A.1    Swift, G.H.2    Hoang, C.Q.3    Deering, T.G.4    Masui, T.5
  • 97
    • 84895442729 scopus 로고    scopus 로고
    • Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation
    • von Figura G, Morris JP IV, Wright CV, Hebrok M. 2014. Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut 63:656-64
    • (2014) Gut , vol.63 , pp. 656-664
    • Von Figura, G.1    Morris, J.P.2    Wright, C.V.3    Hebrok, M.4
  • 98
    • 84870803922 scopus 로고    scopus 로고
    • Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
    • Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, et al. 2012. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell 22:737-50
    • (2012) Cancer Cell , vol.22 , pp. 737-750
    • Kopp, J.L.1    Von Figura, G.2    Mayes, E.3    Liu, F.F.4    Dubois, C.L.5
  • 99
    • 84860390430 scopus 로고    scopus 로고
    • LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function
    • Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, et al. 2011. LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes Dev. 25:1674-79
    • (2011) Genes Dev. , vol.25 , pp. 1674-1679
    • Holmstrom, S.R.1    Deering, T.2    Swift, G.H.3    Poelwijk, F.J.4    Mangelsdorf, D.J.5
  • 100
    • 84924133024 scopus 로고    scopus 로고
    • The bHLHtranscription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
    • PinCL, Rukstalis JM, Johnson C, Konieczny SF. 2001. The bHLHtranscription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J. Cell Biol. 155:519-30
    • (2001) J. Cell Biol. , vol.155 , pp. 519-530
    • Pin, C.L.1    Rukstalis, J.M.2    Johnson, C.3    Konieczny, S.F.4
  • 101
    • 34147119001 scopus 로고    scopus 로고
    • Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis
    • Kowalik AS, Johnson CL,Chadi SA,Weston JY, Fazio EN, Pin CL. 2007. Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 292:G1123-32
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.292 , pp. G1123-G1132
    • Kowalik, A.S.1    Johnson, C.L.2    Chadi, S.A.3    Weston, J.Y.4    Fazio, E.N.5    Pin, C.L.6
  • 102
    • 84865491667 scopus 로고    scopus 로고
    • Bmi1 is required for regeneration of the exocrine pancreas in mice
    • Fukuda A, Morris JP IV, Hebrok M. 2012. Bmi1 is required for regeneration of the exocrine pancreas in mice. Gastroenterology 143:821-31.e2
    • (2012) Gastroenterology , vol.143
    • Fukuda, A.1    Morris, J.P.2    Hebrok, M.3
  • 104
    • 84883410708 scopus 로고    scopus 로고
    • Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells
    • Sun L,Mathews LA, Cabarcas SM, Zhang X, Yang A, et al. 2013. Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells. Stem Cells 31:1454-66
    • (2013) Stem Cells , vol.31 , pp. 1454-1466
    • Sun, L.1    Mathews, L.A.2    Cabarcas, S.M.3    Zhang, X.4    Yang, A.5
  • 105
    • 79959560633 scopus 로고    scopus 로고
    • A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects
    • Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, et al. 2011. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474:506-10
    • (2011) Nature , vol.474 , pp. 506-510
    • Lee, J.M.1    Lee, Y.K.2    Mamrosh, J.L.3    Busby, S.A.4    Griffin, P.R.5
  • 106
    • 33645211374 scopus 로고    scopus 로고
    • Purmorphamine activates the Hedgehog pathway by targeting Smoothened
    • Sinha S, Chen JK. 2006. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat. Chem. Biol. 2:29-30
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 29-30
    • Sinha, S.1    Chen, J.K.2
  • 107
    • 84878340278 scopus 로고    scopus 로고
    • How to make a functional β-cell
    • Pagliuca FW, Melton DA. 2013. How to make a functional β-cell. Development 140:2472-83
    • (2013) Development , vol.140 , pp. 2472-2483
    • Pagliuca, F.W.1    Melton, D.A.2
  • 108
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to β-cells
    • Zhou Q, Brown J, Kanarek A, Rajagopal J,Melton DA. 2008. In vivo reprogramming of adult pancreatic exocrine cells to β-cells. Nature 455:627-32
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 109
    • 84898477228 scopus 로고    scopus 로고
    • In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes
    • Li W, Nakanishi M, Zumsteg A, Shear M, Wright C, et al. 2014. In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. eLife 3:e01846
    • (2014) ELife , vol.3 , pp. e01846
    • Li, W.1    Nakanishi, M.2    Zumsteg, A.3    Shear, M.4    Wright, C.5
  • 110
    • 84892173922 scopus 로고    scopus 로고
    • Transient cytokine treatment induces acinar cell reprogramming and regenerates functionalβcell mass in diabetic mice
    • Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, et al. 2014. Transient cytokine treatment induces acinar cell reprogramming and regenerates functionalβcell mass in diabetic mice. Nat. Biotechnol. 32:76-83
    • (2014) Nat. Biotechnol. , vol.32 , pp. 76-83
    • Baeyens, L.1    Lemper, M.2    Leuckx, G.3    De Groef, S.4    Bonfanti, P.5
  • 111
    • 57749116315 scopus 로고    scopus 로고
    • Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    • De La O J-P, Emerson LL, Goodman JL, Froebe SC, Illum BE, et al. 2008. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. PNAS 105:18907-12
    • (2008) PNAS , vol.105 , pp. 18907-18912
    • De La, O.J.-P.1    Emerson, L.L.2    Goodman, J.L.3    Froebe, S.C.4    Illum, B.E.5
  • 112
    • 84892711349 scopus 로고    scopus 로고
    • Pathogenesis of pancreatic cancer: Lessons from animal models
    • Murtaugh LC. 2014. Pathogenesis of pancreatic cancer: lessons from animal models. Toxicol. Pathol. 42:217-28
    • (2014) Toxicol. Pathol. , vol.42 , pp. 217-228
    • Murtaugh, L.C.1
  • 114
    • 79953761842 scopus 로고    scopus 로고
    • Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    • Fukuda A, Wang SC, Morris JP IV, Folias AE, Liou A, et al. 2011. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell 19:441-55
    • (2011) Cancer Cell , vol.19 , pp. 441-455
    • Fukuda, A.1    Wang, S.C.2    Morris, J.P.3    Folias, A.E.4    Liou, A.5
  • 115
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, et al. 2011. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 19:456-69
    • (2011) Cancer Cell , vol.19 , pp. 456-469
    • Lesina, M.1    Kurkowski, M.U.2    Ludes, K.3    Rose-John, S.4    Treiber, M.5
  • 116
    • 84859710888 scopus 로고    scopus 로고
    • An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice
    • Daniluk J, Liu Y, Deng D, Chu J,Huang H, et al. 2012. An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J. Clin. Investig. 122:1519-28
    • (2012) J. Clin. Investig. , vol.122 , pp. 1519-1528
    • Daniluk, J.1    Liu, Y.2    Deng, D.3    Chu, J.4    Huang, H.5
  • 117
    • 84878220272 scopus 로고    scopus 로고
    • Requirement of NEMO/IKKγfor effective expansion of KRAS-induced precancerous lesions in the pancreas
    • Maier HJ, Wagner M, Schips TG, Salem HH, Baumann B, Wirth T. 2012. Requirement of NEMO/IKKγfor effective expansion of KRAS-induced precancerous lesions in the pancreas. Oncogene 32:2690-95
    • (2012) Oncogene , vol.32 , pp. 2690-2695
    • Maier, H.J.1    Wagner, M.2    Schips, T.G.3    Salem, H.H.4    Baumann, B.5    Wirth, T.6
  • 118
    • 84055217307 scopus 로고    scopus 로고
    • Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
    • Maniati E, Bossard M, Cook N, Candido JB, Emami-Shahri N, et al. 2011. Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. J. Clin. Investig. 121:4685-99
    • (2011) J. Clin. Investig. , vol.121 , pp. 4685-4699
    • Maniati, E.1    Bossard, M.2    Cook, N.3    Candido, J.B.4    Emami-Shahri, N.5
  • 119
    • 77953158971 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma
    • Hanlon L, Avila JL, Demarest RM, Troutman S, Allen M, et al. 2010. Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res. 70:4280-86
    • (2010) Cancer Res. , vol.70 , pp. 4280-4286
    • Hanlon, L.1    Avila, J.L.2    Demarest, R.M.3    Troutman, S.4    Allen, M.5
  • 120
    • 62949182142 scopus 로고    scopus 로고
    • Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia
    • Shi G, Zhu L, Sun Y, Bettencourt R, Damsz B, et al. 2009. Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia. Gastroenterology 136:1368-78
    • (2009) Gastroenterology , vol.136 , pp. 1368-1378
    • Shi, G.1    Zhu, L.2    Sun, Y.3    Bettencourt, R.4    Damsz, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.