메뉴 건너뛰기




Volumn 144, Issue 1, 2013, Pages 192-201

Deletion of IκB activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A

Author keywords

Gene Regulation; Mouse Model; Pancreatic Inflammation; SNP Analysis

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; ARGININE; CERULETIDE; CRE RECOMBINASE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SERINE PROTEASE INHIBITOR 2A; SERINE PROTEINASE INHIBITOR; TRANSCRIPTION FACTOR RELA; TRYPSIN; UNCLASSIFIED DRUG;

EID: 84871282951     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.09.058     Document Type: Article
Times cited : (59)

References (34)
  • 1
    • 0033529050 scopus 로고    scopus 로고
    • Acute necrotizing pancreatitis
    • T.H. Baron, D.E. Morgan Acute necrotizing pancreatitis N Engl J Med 340 1999 1412 1417
    • (1999) N Engl J Med , vol.340 , pp. 1412-1417
    • Baron, T.H.1    Morgan, D.E.2
  • 4
    • 34247197621 scopus 로고    scopus 로고
    • Chronic pancreatitis: Challenges and advances in pathogenesis, genetics, diagnosis, and therapy
    • H. Witt, M.V. Apte, V. Keim Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy Gastroenterology 132 2007 1557 1573
    • (2007) Gastroenterology , vol.132 , pp. 1557-1573
    • Witt, H.1    Apte, M.V.2    Keim, V.3
  • 5
    • 0022651240 scopus 로고
    • Activation of pancreatic zymogens Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation
    • H. Rinderknecht Activation of pancreatic zymogens Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation Dig Dis Sci 31 1986 314 321
    • (1986) Dig Dis Sci , vol.31 , pp. 314-321
    • Rinderknecht, H.1
  • 6
    • 81855228093 scopus 로고    scopus 로고
    • Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis
    • R. Dawra, R.P. Sah, V. Dudeja Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis Gastroenterology 141 2011 2210 2217.e2
    • (2011) Gastroenterology , vol.141
    • Dawra, R.1    Sah, R.P.2    Dudeja, V.3
  • 7
    • 77950210797 scopus 로고    scopus 로고
    • Betacellulin protects from pancreatitis by activating stress-activated protein kinase
    • M. Dahlhoff, H. Algul, J.T. Siveke Betacellulin protects from pancreatitis by activating stress-activated protein kinase Gastroenterology 138 2010 1585 1594
    • (2010) Gastroenterology , vol.138 , pp. 1585-1594
    • Dahlhoff, M.1    Algul, H.2    Siveke, J.T.3
  • 8
    • 33846994097 scopus 로고    scopus 로고
    • Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2
    • T. Aleksic, B. Baumann, M. Wagner Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2 Gut 56 2007 227 236
    • (2007) Gut , vol.56 , pp. 227-236
    • Aleksic, T.1    Baumann, B.2    Wagner, M.3
  • 9
    • 34249879045 scopus 로고    scopus 로고
    • Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis
    • H. Algul, M. Treiber, M. Lesina Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis J Clin Invest 117 2007 1490 1501
    • (2007) J Clin Invest , vol.117 , pp. 1490-1501
    • Algul, H.1    Treiber, M.2    Lesina, M.3
  • 10
    • 34249887978 scopus 로고    scopus 로고
    • Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo
    • B. Baumann, M. Wagner, T. Aleksic Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo J Clin Invest 117 2007 1502 1513
    • (2007) J Clin Invest , vol.117 , pp. 1502-1513
    • Baumann, B.1    Wagner, M.2    Aleksic, T.3
  • 11
    • 0036007501 scopus 로고    scopus 로고
    • NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response
    • X. Chen, B. Ji, B. Han NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response Gastroenterology 122 2002 448 457
    • (2002) Gastroenterology , vol.122 , pp. 448-457
    • Chen, X.1    Ji, B.2    Han, B.3
  • 12
    • 40249109853 scopus 로고    scopus 로고
    • The IkappaB kinase - A bridge between inflammation and cancer
    • M. Karin The IkappaB kinase - a bridge between inflammation and cancer Cell Res 18 2008 334 342
    • (2008) Cell Res , vol.18 , pp. 334-342
    • Karin, M.1
  • 13
    • 0028978032 scopus 로고
    • Phosphorylation of human i kappa B-alpha on serines 32 and 36 controls i kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli
    • E.B. Traenckner, H.L. Pahl, T. Henkel Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli EMBO J 14 1995 2876 2883
    • (1995) EMBO J , vol.14 , pp. 2876-2883
    • Traenckner, E.B.1    Pahl, H.L.2    Henkel, T.3
  • 14
    • 0033961280 scopus 로고    scopus 로고
    • Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB
    • L.V. Madrid, C.Y. Wang, D.C. Guttridge Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB Mol Cell Biol 20 2000 1626 1638
    • (2000) Mol Cell Biol , vol.20 , pp. 1626-1638
    • Madrid, L.V.1    Wang, C.Y.2    Guttridge, D.C.3
  • 15
    • 0032953146 scopus 로고    scopus 로고
    • Structural analysis, expression, and chromosomal localization of the mouse ikba gene
    • R.A. Rupec, D. Poujol, J. Grosgeorge Structural analysis, expression, and chromosomal localization of the mouse ikba gene Immunogenetics 49 1999 395 403
    • (1999) Immunogenetics , vol.49 , pp. 395-403
    • Rupec, R.A.1    Poujol, D.2    Grosgeorge, J.3
  • 16
    • 80053588704 scopus 로고    scopus 로고
    • Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis
    • 1485 e1-7
    • M. Treiber, P. Neuhofer, E. Anetsberger Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis Gastroenterology 141 2011 1473 1485 1485 e1-7
    • (2011) Gastroenterology , vol.141 , pp. 1473-1485
    • Treiber, M.1    Neuhofer, P.2    Anetsberger, E.3
  • 17
    • 34147189490 scopus 로고    scopus 로고
    • Development of a new mouse model of acute pancreatitis induced by administration of L-arginine
    • R. Dawra, R. Sharif, P. Phillips Development of a new mouse model of acute pancreatitis induced by administration of L-arginine Am J Physiol Gastrointest Liver Physiol 292 2007 G1009 G1018
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Dawra, R.1    Sharif, R.2    Phillips, P.3
  • 18
    • 34548047674 scopus 로고    scopus 로고
    • Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin
    • B. Rebholz, I. Haase, B. Eckelt Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin Immunity 27 2007 296 307
    • (2007) Immunity , vol.27 , pp. 296-307
    • Rebholz, B.1    Haase, I.2    Eckelt, B.3
  • 19
    • 34247390587 scopus 로고    scopus 로고
    • Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina
    • H. Nakhai, S. Sel, J. Favor Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina Development 134 2007 1151 1160
    • (2007) Development , vol.134 , pp. 1151-1160
    • Nakhai, H.1    Sel, S.2    Favor, J.3
  • 20
    • 84859398141 scopus 로고    scopus 로고
    • CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice
    • K. Saeki, T. Kanai, M. Nakano CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice Gastroenterology 142 2012 1010 1020.e9
    • (2012) Gastroenterology , vol.142
    • Saeki, K.1    Kanai, T.2    Nakano, M.3
  • 21
    • 58149165209 scopus 로고    scopus 로고
    • Basic and translational research on proteinase-activated receptors: Implication of proteinase/proteinase-activated receptor in gastrointestinal inflammation
    • N. Yoshida, T. Yoshikawa Basic and translational research on proteinase-activated receptors: implication of proteinase/proteinase-activated receptor in gastrointestinal inflammation J Pharmacol Sci 108 2008 415 421
    • (2008) J Pharmacol Sci , vol.108 , pp. 415-421
    • Yoshida, N.1    Yoshikawa, T.2
  • 22
    • 0032590082 scopus 로고    scopus 로고
    • NF-kappaB/Rel activation in cerulein pancreatitis
    • A.U. Steinle, H. Weidenbach, M. Wagner NF-kappaB/Rel activation in cerulein pancreatitis Gastroenterology 116 1999 420 430
    • (1999) Gastroenterology , vol.116 , pp. 420-430
    • Steinle, A.U.1    Weidenbach, H.2    Wagner, M.3
  • 23
    • 0035554032 scopus 로고    scopus 로고
    • From acinar cell damage to systemic inflammatory response: Current concepts in pancreatitis
    • C.K. Weber, G. Adler From acinar cell damage to systemic inflammatory response: current concepts in pancreatitis Pancreatology 1 2001 356 362
    • (2001) Pancreatology , vol.1 , pp. 356-362
    • Weber, C.K.1    Adler, G.2
  • 24
    • 0036436837 scopus 로고    scopus 로고
    • Acute experimental pancreatitis and NF-kappaB/Rel activation
    • H. Algul, Y. Tando, G. Schneider Acute experimental pancreatitis and NF-kappaB/Rel activation Pancreatology 2 2002 503 509
    • (2002) Pancreatology , vol.2 , pp. 503-509
    • Algul, H.1    Tando, Y.2    Schneider, G.3
  • 25
    • 0032246276 scopus 로고    scopus 로고
    • Early NF-kappaB activation is associated with hormone-induced pancreatitis
    • I. Gukovsky, A.S. Gukovskaya, T.A. Blinman Early NF-kappaB activation is associated with hormone-induced pancreatitis Am J Physiol 275 1998 G1402 G1414
    • (1998) Am J Physiol , vol.275
    • Gukovsky, I.1    Gukovskaya, A.S.2    Blinman, T.A.3
  • 26
    • 34249794259 scopus 로고    scopus 로고
    • IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappa B activation
    • T. Hayashi, Y. Ishida, A. Kimura IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappa B activation J Immunol 178 2007 7385 7394
    • (2007) J Immunol , vol.178 , pp. 7385-7394
    • Hayashi, T.1    Ishida, Y.2    Kimura, A.3
  • 27
    • 38549084647 scopus 로고    scopus 로고
    • The role of NF-kappaB activation in the pathogenesis of acute pancreatitis
    • Z. Rakonczay Jr, P. Hegyi, T. Takacs The role of NF-kappaB activation in the pathogenesis of acute pancreatitis Gut 57 2008 259 267
    • (2008) Gut , vol.57 , pp. 259-267
    • Rakonczay, Jr.Z.1    Hegyi, P.2    Takacs, T.3
  • 28
    • 3042589745 scopus 로고    scopus 로고
    • Serine protease inhibitor 2A inhibits caspase-independent cell death
    • N. Liu, Y. Wang, P.G. Ashton-Rickardt Serine protease inhibitor 2A inhibits caspase-independent cell death FEBS Lett 569 2004 49 53
    • (2004) FEBS Lett , vol.569 , pp. 49-53
    • Liu, N.1    Wang, Y.2    Ashton-Rickardt, P.G.3
  • 29
    • 0141753121 scopus 로고    scopus 로고
    • NF-kappaB protects from the lysosomal pathway of cell death
    • N. Liu, S.M. Raja, F. Zazzeroni NF-kappaB protects from the lysosomal pathway of cell death EMBO J 22 2003 5313 5322
    • (2003) EMBO J , vol.22 , pp. 5313-5322
    • Liu, N.1    Raja, S.M.2    Zazzeroni, F.3
  • 30
    • 33747766204 scopus 로고    scopus 로고
    • Human pancreatitis and the role of cathepsin B
    • M.M. Lerch, W. Halangk Human pancreatitis and the role of cathepsin B Gut 55 2006 1228 1230
    • (2006) Gut , vol.55 , pp. 1228-1230
    • Lerch, M.M.1    Halangk, W.2
  • 31
    • 0023904236 scopus 로고
    • Possible lysosomal activation of pancreatic zymogens Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1
    • C. Figarella, B. Miszczuk-Jamska, A.J. Barrett Possible lysosomal activation of pancreatic zymogens Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1 Biol Chem Hoppe Seyler 369 Suppl 1988 293 298
    • (1988) Biol Chem Hoppe Seyler , vol.369 , Issue.SUPPL. , pp. 293-298
    • Figarella, C.1    Miszczuk-Jamska, B.2    Barrett, A.J.3
  • 32
    • 0033795691 scopus 로고    scopus 로고
    • Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    • W. Halangk, M.M. Lerch, B. Brandt-Nedelev Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis J Clin Invest 106 2000 773 781
    • (2000) J Clin Invest , vol.106 , pp. 773-781
    • Halangk, W.1    Lerch, M.M.2    Brandt-Nedelev, B.3
  • 33
    • 34548225362 scopus 로고    scopus 로고
    • NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    • F.R. Greten, M.C. Arkan, J. Bollrath NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta Cell 130 2007 918 931
    • (2007) Cell , vol.130 , pp. 918-931
    • Greten, F.R.1    Arkan, M.C.2    Bollrath, J.3
  • 34
    • 0034039578 scopus 로고    scopus 로고
    • Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    • H. Witt, W. Luck, H.C. Hennies Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis Nat Genet 25 2000 213 216
    • (2000) Nat Genet , vol.25 , pp. 213-216
    • Witt, H.1    Luck, W.2    Hennies, H.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.