Early NF-κB activation is associated with hormone-induced pancreatitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 275, Issue 6 38-6, 1998, Pages

  Gukovsky, Ilya ^a,b   Gukovskaya, Anna S ^a   Blinman, Thane A ^a   Zaninovic, Vjekoslav ^a   Pandol, Stephen J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Interleukin 6; I B; KC; Pancreatic acinar cell

Indexed keywords

ACETYLCYSTEINE; CERULETIDE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; N TERT BUTYLOXYCARBONYLCHOLECYSTOKININ[27-32][28,31 NORLEUCINE] PHENETHYL ESTER; TUMOR NECROSIS FACTOR ALPHA; ANTIOXIDANT; CHEMOKINE; CHOLECYSTOKININ OCTAPEPTIDE; DNA BINDING PROTEIN; DRUG DERIVATIVE; I KAPPA B; KERATINOCYTE DERIVED CHEMOKINES; KERATINOCYTE-DERIVED CHEMOKINES;

ACINAR CELL; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; GENE EXPRESSION; HORMONE ACTION; KINETICS; MALE; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TRANSPORT; RAT; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; ISOMERISM; METABOLISM; PANCREAS; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CAERULEIN; CHEMOKINES; CYTOKINES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; I-KAPPA B PROTEINS; INTERLEUKIN-6; ISOMERISM; KINETICS; MALE; NF-KAPPA B; PANCREAS; PANCREATITIS; RATS; RATS, SPRAGUE-DAWLEY; SINCALIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032246276     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.275.6.g1402     Document Type: Article

References (22)

1. Arenzana-Seisdedos, F., J. Thompson, M. S. Rodriguez, F. Bachelerie, D. Thomas, and R. T. Hay. Inducible nuclear expression of newly synthesized IkBa negatively regulates DNA-binding and transcriptional activities of NF-κB. Mol. Cell. Biol. 15: 2689-2696, 1995.
2. Baggiolini, M., B. Dewald, and B. Moser. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol. 55: 97-179, 1994.
3. Barnes, P. J., and M. Karin. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336: 1066-1071, 1997.
4. Ben-Baruch, A., D. F. Michiel, and J. J. Oppenheim. Signals and receptors involved in recruitment of inflammatory cells. J. Biol. Chem. 270: 11703-11706, 1995.
5. Bradley, P. P., D. A. Priebat, R. D. Christensen, and G. Rothstein. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol. 78: 206-209, 1982.
6. Brennan, P., and L. A. O'Neill. Effects of oxidants and antioxidants on nuclear factor κB activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals. Biochim. Biophys. Acta 1260: 167-175, 1995.
7. Celi, F. S., M. E. Zenilman, and A. R. Shuldiner. A rapid and versatile method to synthesize internal standards for competitive PCR. Nucleic Acids Res. 21: 1047, 1993.
8. Dabrowski, A., A. Gabryelewicz, and L. Chyczewski. The effect of platelet activating factor antagonist (BN 52021) on cerulein-induced acute pancreatitis with reference to oxygen radicals. Int. J. Pancreatol. 8: 1-11, 1991.
9. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11: 1475-1489, 1983.
10. Dunn, J. A., C. Li, T. Ha, R. L. Kao, and W. Browder. Therapeutic modification of nuclear factor κB binding activity and tumor necrosis factor-a gene expression during acute biliary pancreatitis. Am. Surg. 63: 1036-1043, 1997.
11. Flohe, L., R. Brigelius-Flohe, C. Saliou, M. G. Traber, and L. Packer. Redox regulation of NF-κB activation. Free Radic. Biol. Med. 22: 1115-1126, 1997.
12. Formela, L. J., S. W. Galloway, and A. N. Kingsnorth. Inflammatory mediators in acute pancreatitis. Br. J. Surg. 82: 6-13, 1995.
13. Fu, K., M. P. Sarras, R. C. De Lisle, and G. K. Andrews. Expression of oxidative stress-responsive genes and cytokine genes during caerulein-induced acute pancreatitis. Am. J. Physiol. 273 (Gastrointest. Liver Physiol. 36): G696-G705, 1997.
14. Gorelick, F. S., G. Adler, and H. F. Kern. Cerulein-induced pancreatitis. In: The Pancreas: Biology, Pathobiology, and Disease (2nd ed.), edited by V. W. Go, E. P. DiMagno, J. D. Gardner, E. Lebenthal, H. A. Reber, and G. A. Scheele. New York: Raven, 1993, p. 501-526.
15. Grewal, H. P., A. M. el Din, L. Gaber, M. Kotb, and A. O. Gaber. Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-a polyclonal antibody. Am. J. Surg. 167: 214-218, 1994.
16. Gross, V., R. Andreesen, H. G. Leser, M. Ceska, E. Liehl, M. Lausen, E. H. Farthmann, and J. Scholmerich. Interleukin-8 and neutrophil activation in acute pancreatitis. Eur. J. Clin. Invest. 22: 200-203, 1992.
17. Gross, V., H. G. Leser, A. Heinisch, and J. Schölmerich. Inflammatory mediators and cytokines - new aspects of the pathophysiology and assessment of severity of acute pancreatitis? Hepatogastroenterology 40: 522-530, 1993.
18. Gukovskaya, A. S., I. Gukovsky, V. Zaninovic, D. T. Kira, and S. J. Pandol. Metalloproteinases regulate signal transduction pathways triggered by extracellular matrix proteins (Abstract). Gastroenterology, Suppl. 114: A464-A465, 1998.
19. Gukovskaya, A, S., I. Gukovsky, V. Zaninovic, M. Song, D. Sandoval, S. Gukovsky, and S. J. Pandol. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-a. Role in regulating cell death and pancreatitis. J. Clin. Invest. 100: 1853-1862, 1997.
20. Gukovsky, I., T. A. Blinman, V. Zaninovic, Y. Jung, A. S. Gukovskaya, and S. J. Pandol. Role of transcription factor NF-κB in mediating hormone-induced pancreatitis (Abstract). Gastroenterology, Suppl. 114: A465, 1998.
21. Gukovsky, I., A. S. Gukovskaya, and S. J. Pandol. Cerulein activates NF-κB and AP-1 in isolated pancreatic acinar cells (Abstract). Gastroenterology, Suppl. 114: A465, 1998.
22. Gukovsky, I., A. S. Gukovskaya, V. Zaninovic, S. Periskic, H. Tsukamoto, and S. J. Pandol. NF-κB activation is an early marker of pancreatic acinar cell injury in rat cerulein pancreatitis (Abstract). Gastroenterology, Suppl. 112: A446, 1997.