Genetic risk factors for pancreatic disorders

Gastroenterology

Volumn 144, Issue 6, 2013, Pages 1292-1302

  Whitcomb, David C ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Alcoholism; Chronic Disease; Complex Traits; Cystic Fibrosis; Hereditary Pancreatitis; Personalized Medicine

Indexed keywords

ALCOHOL; CALCIUM SENSING RECEPTOR; CHYMOTRYPSIN; CLAUDIN 2; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; INTERLEUKIN 23 RECEPTOR; PANCREATIC SECRETORY TRYPSIN INHIBITOR 1; PROTEIN; PROTEIN PRSS1; PROTEIN PRSS2; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; STRATUM CORNEUM CHYMOTRYPTIC ENZYME; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; ALCOHOL CONSUMPTION; AUTOIMMUNE DISEASE; AUTOIMMUNE PANCREATITIS; CALCIUM CELL LEVEL; CELLULAR STRESS RESPONSE; CHRONIC PANCREATITIS; DISEASE COURSE; ENZYME ACTIVATION; GENE LOCUS; GENE SEQUENCE; GENETIC COUNSELING; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETICS; HEREDITY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; LOSS OF FUNCTION MUTATION; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REGENERATION; REVIEW; TH17 CELL;

EID: 84876813879     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.01.069     Document Type: Article

References (123)

1. D.C. Whitcomb What is personalized medicine and should it replace? Nat Rev Gastroenterol Hepatol 9 2012 418 424
2. M.C. Gorry, D. Gabbaizedeh, W. Furey Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis Gastroenterology 113 1997 1063 1068
3. D.C. Whitcomb, M.C. Gorry, R.A. Preston Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene Nat Genet 14 1996 141 145
4. H. Witt, M.V. Apte, V. Keim Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy Gastroenterology 132 2007 1557 1573
5. J.M. Chen, C. Ferec Chronic pancreatitis: genetics and pathogenesis Annu Rev Genomics Hum Genet 10 2009 63 87
6. D.C. Whitcomb Genetic aspects of pancreatitis Annu Rev Med 61 2010 413 424
7. J. Larusch, D.C. Whitcomb Genetics of pancreatitis Curr Opin Gastroenterol 27 2011 467 474
8. J.M. Chen, C. Ferec Genetics and pathogenesis of chronic pancreatitis: the 2012 update Clin Res Hepatol Gastroenterol 36 2012 334 340
9. D.C. Whitcomb, J. LaRusch, A.M. Krasinskas Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis Nat Genet 44 2012 1349 1354
10. K.T. Coppieters, A. Wiberg, S.M. Tracy Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma Clin Exp Immunol 168 2012 5 11
11. D.C. Whitcomb Mechanisms of disease: advances in understanding the mechanisms leading to chronic pancreatitis Nat Clin Pract Gastroenterol Hepatol 1 2004 46 52
12. B. Etemad, D.C. Whitcomb Chronic pancreatitis: diagnosis, classification, and new genetic developments Gastroenterology 120 2001 682 707
13. D.C. Whitcomb Hereditary pancreatitis: new insights into acute and chronic pancreatitis Gut 45 1999 317 322
14. D. Yadav, D.C. Whitcomb The role of alcohol and smoking in pancreatitis Nat Rev Gastroenterol Hepatol 7 2010 131 145
15. D.C. Whitcomb, M.M. Barmada A systems biology approach to genetic studies of pancreatitis and other complex diseases Cell Mol Life Sci 64 2007 1763 1777
16. C. Jacob, P.C. Yang, D. Darmoul Mast cell tryptase controls paracellular permeability of the intestine Role of protease-activated receptor 2 and beta-arrestins J Biol Chem 280 2005 31936 31948
17. H. Mogami, K. Nakano, A.V. Tepikin Ca2+ flow via tunnels in polarized cells: recharging of apical Ca2+ stores by focal Ca2+ entry through basal membrane patch Cell 88 1997 49 55
18. M. Raraty, J. Ward, G. Erdemli Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells Proc Natl Acad Sci U S A 97 2000 13126 13131
19. R. Sutton, D. Criddle, M.G. Raraty Signal transduction, calcium and acute pancreatitis Pancreatology 3 2003 497 505
20. D.N. Criddle, M.G. Raraty, J.P. Neoptolemos Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites Proc Natl Acad Sci U S A 101 2004 10738 10743
21. M.M. Lerch, F.S. Gorelick Early trypsinogen activation in acute pancreatitis Med Clin North Am 84 2000 549 563
22. K. Fernandez-Del Castillo, C. Mithofer, T.W. Frick Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat Gastroenterology 109 1995 239 246
23. T.W. Fernandez-del Castillo, C. Frick, D. Bimmler Elevated calcium and activation of trypsinogen in rat pancreatic acini Gut 41 1997 339 343
24. Z. Kukor, M. Tóth, M. Sahin-Tóth Human anionic trypsinogen Eur J Biochem 270 2003 2047 2058
25. J.H. Liu, Z.X. Wang Kinetic analysis of ligand-induced autocatalytic reactions Biochem J 379 2004 697 702
26. E. Colomb, C. Figarella Comparative studies on the mechanism of activation of the two human trypsinogens Biochim Biophys Acta 571 1979 343 351
27. O. Guy, D. Lombardo, D.C. Bartelt Two human trypsinogens Purification, molecular properties, and N-terminal sequences Biochemistry 17 1978 1669 1675
28. W.S. Bennett, R. Huber Structural and functional aspects of domain motions in proteins CRC Crit Rev Biochem 15 1984 291 384
29. Z. Nemoda, M. Sahin-Toth The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition J Biol Chem 280 2005 29645 29652
30. H. Rinderknecht, I.G. Renner, S.B. Abramson Mesotrypsin: a new inhibitor-resistant protease from a zymogen in human pancreatic tissue and fluid Gastroenterology 86 1984 681 692
31. M. Bhoomagoud, T. Jung, J. Atladottir Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats Gastroenterology 137 2009 1083 1092
32. D. Yadav, S. Nair, E.P. Norkus Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities Am J Gastroenterol 95 2000 3123 3128
33. S. Nair, D. Yadav, C.S. Pitchumoni Association of diabetic ketoacidosis and acute pancreatitis: observations in 100 consecutive episodes of DKA Am J Gastroenterol 95 2000 2795 2800
34. Z. Kukor, J. Mayerle, B. Kruger Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis J Biol Chem 277 2002 21389 21396
35. S. Beer, J. Zhou, A. Szabo Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk Gut 2012 Sep 1 [Epub ahead of print]
36. A. Szabo, M. Sahin-Toth Determinants of chymotrypsin C cleavage specificity in the calcium binding loop of human cationic trypsinogen FEBS J 279 2012 4283 4292
37. D.C. Whitcomb, M.E. Lowe Human pancreatic digestive enzymes Dig Dis Sci 52 2007 1 17
38. A. Khalid, S. Finkelstein, B. Thompson A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression, and no pancreatitis: insights into phenotypic non-penetrance Gut 55 2006 728 731
39. A. Lasson, A. Borgstrom, K. Ohlsson Elevated pancreatic secretory trypsin inhibitor levels during severe inflammatory disease, renal insufficiency, and after various surgical procedures Scand J Gastroenterol 21 1986 1275 1280
40. M. Ogawa Pancreatic secretory trypsin inhibitor as an acute phase reactant Clin Biochem 21 1988 19 25
41. E. Masson, J.M. Chen, V. Scotet Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis Hum Genet 123 2008 83 91
42. J. Rosendahl, H. Witt, R. Szmola Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis Nat Genet 40 2008 78 82
43. R.H. Pfutzer, M.M. Barmada, A.P. Brunskill SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis Gastroenterology 119 2000 615 623
44. H. Witt, W. Luck, H.C. Hennies Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis Nat Genet 25 2000 213 216
45. E. Aoun, C.C. Chang, J.B. Greer Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis PLoS ONE 3 2008 e2003
46. W.H. Marks, K. Ohlsson, A. Polling Immunocytochemical distribution of trypsinogen and pancreatic secretory trypsin inhibitor in normal and neoplastic tissues in man Scand J Gastroenterol 19 1984 673 676
47. J. Sand, P.G. Lankisch, I. Nordback Alcohol consumption in patients with acute or chronic pancreatitis Pancreatology 7 2007 147 156
48. M. Apte, R. Pirola, J. Wilson New insights into alcoholic pancreatitis and pancreatic cancer J Gastroenterol Hepatol 24 Suppl 3 2009 S51 S56
49. Z. Lu, S. Karne, T. Kolodecik Alcohols enhance caerulein-induced zymogen activation in pancreatic acinar cells Am J Physiol Gastrointest Liver Physiol 282 2002 G501 G507
50. S.J. Pandol, S. Periskic, I. Gukovsky Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide Gastroenterology 117 1999 706 716
51. X. Deng, P.G. Wood, P.K. Eagon Chronic alcohol-induced alterations in the pancreatic secretory control mechanisms Dig Dis Sci 49 2004 805 819
52. I. Nordback, H. Pelli, R. Lappalainen-Lehto Is it long-term continuous drinking or the post-drinking withdrawal period that triggers the first acute alcoholic pancreatitis? Scand J Gastroenterol 40 2005 1235 1239
53. D. Yadav, M.L. Eigenbrodt, M.J. Briggs Pancreatitis: prevalence and risk factors among male veterans in a detoxification program Pancreas 34 2007 390 398
54. D. Yadav, R.H. Hawes, R.E. Brand Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis Arch Intern Med 169 2009 1035 1045
55. M.G. Lee, E. Ohana, H.W. Park Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion Physiol Rev 92 2012 39 74
56. D.C. Whitcomb, G.B. Ermentrout A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice Pancreas 29 2004 E30 E40
57. K.K. Hansen, P.M. Sherman, L. Cellars A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis Proc Natl Acad Sci U S A 102 2005 8363 8368
58. A. Sharma, X. Tao, A. Gopal Protection against acute pancreatitis by activation of protease-activated receptor-2 Am J Physiol Gastrointest Liver Physiol 288 2005 G388 G395
59. M.C. Steward, H. Ishiguro Molecular and cellular regulation of pancreatic duct cell function Curr Opin Gastroenterol 25 2009 447 453
60. H.W. Park, J.H. Nam, J.Y. Kim Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretion Gastroenterology 139 2010 620 631
61. R.K. Rowntree, A. Harris The phenotypic consequences of CFTR mutations Ann Hum Genet 67 2003 471 485
62. E. Kerem Atypical CF and CF related diseases Paediatr Respir Rev 7 Suppl 1 2006 S144 S146
63. C.Y. Ooi, R. Dorfman, M. Cipolli Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis Gastroenterology 140 2011 153 161
64. N. Sharer, M. Schwarz, G. Malone Mutations of the cystic fibrosis gene in patients with chronic pancreatitis N Engl J Med 339 1998 645 652
65. J.A. Cohn, K.J. Friedman, P.G. Noone Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis N Engl J Med 339 1998 653 658
66. A. Schneider, J. Larusch, X. Sun Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis Gastroenterology 140 2011 162 171
67. M.P. Audrezet, J.M. Chen, C. Le Marechal Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis Eur J Hum Genet 10 2002 100 106
68. A. Sobczynska-Tomaszewska, D. Bak, B. Oralewska Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis J Pediatr Gastroenterol Nutr 43 2006 299 306
69. J. Rosendahl, O. Landt, J. Bernadova CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated? Gut 62 2013 582 592
70. R. de Cid, M.D. Ramos, L. Aparisi Independent contribution of common CFTR variants to chronic pancreatitis Pancreas 39 2010 209 215
71. S. Midha, R. Khajuria, S. Shastri Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations Gut 59 2010 800 807
72. Y.T. Chang, M.C. Chang, T.C. Su Association of cystic fibrosis transmembrane conductance regulator (CFTR) mutation/variant/haplotype and tumor necrosis factor (TNF) promoter polymorphism in hyperlipidemic pancreatitis Clin Chem 54 2008 131 138
73. M.C. Chang, Y.T. Chang, S.C. Wei Spectrum of mutations and variants/haplotypes of CFTR and genotype-phenotype correlation in idiopathic chronic pancreatitis and controls in Chinese by complete analysis Clin Genet 71 2007 530 539
74. P.G. Noone, Z. Zhou, L.M. Silverman Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations Gastroenterology 121 2001 1310 1319
75. C. Bombieri, M. Claustres, K. De Boeck Recommendations for the classification of diseases as CFTR-related disorders J Cyst Fibros 10 Suppl 2 2011 S86 S102
76. S. Solomon, D.C. Whitcomb Genetics of pancreatitis: an update for clinicians and genetic counselors Curr Gastroenterol Rep 14 2012 112 117
77. T. Shimosegawa, S.T. Chari, L. Frulloni International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology Pancreas 40 2011 352 358
78. R.P. Sah, S.T. Chari, R. Pannala Differences in clinical profile and relapse rate of type 1 versus type 2 autoimmune pancreatitis Gastroenterology 139 2010 140 148
79. G. Kloppel, S. Detlefsen, S.T. Chari Autoimmune pancreatitis: the clinicopathological characteristics of the subtype with granulocytic epithelial lesions J Gastroenterol 45 2010 787 793
80. T.L. Freitag, C. Cham, H.H. Sung Human risk allele HLA-DRB1*0405 predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis Gastroenterology 139 2010 281 291
81. M. Ota, Y. Katsuyama, H. Hamano Two critical genes (HLA-DRB1 and ABCF1) in the HLA region are associated with the susceptibility to autoimmune pancreatitis Immunogenetics 59 2007 45 52
82. F. Asghari, B. Fitzner, S.A. Holzhuter Identification of quantitative trait loci for murine autoimmune pancreatitis J Med Genet 48 2011 557 562
83. T. Stevens, D.L. Conwell, G. Zuccaro Pathogenesis of chronic pancreatitis: an evidence-based review of past theories and recent developments Am J Gastroenterol 99 2004 2256 2270
84. D. Yadav, M. O'Connell, G.I. Papachristou Natural history following the first attack of acute pancreatitis Am J Gastroenterol 107 2012 1096 1103
85. N. Howes, M.M. Lerch, W. Greenhalf Clinical and genetic characteristics of hereditary pancreatitis in Europe Clin Gastroenterol Hepatol 2 2004 252 261
86. V. Rebours, M.C. Boutron-Ruault, M. Schnee The natural history of hereditary pancreatitis: a national series Gut 58 2009 97 103
87. J. Threadgold, W. Greenhalf, I. Ellis The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease Gut 50 2002 675 681
88. D. Yadav, L. Timmons, J.T. Benson Incidence, prevalence, and survival of chronic pancreatitis: a population-based study Am J Gastroenterol 106 2011 2192 2199
89. E. Aoun, V. Muddana, G.I. Papachristou SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event Am J Gastroenterol 105 2010 446 451
90. A. Masamune, H. Ariga, K. Kume Genetic background is different between sentinel and recurrent acute pancreatitis J Gastroenterol Hepatol 26 2011 974 978
91. A. Schneider, R.H. Pfützer, M.M. Barmada Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis - a preliminary report from the United States Dig Dis Sci 48 2003 1110 1115
92. K.H. Lee, J.K. Ryu, W.J. Yoon Mutation analysis of SPINK1 and CFTR gene in Korean patients with alcoholic chronic pancreatitis Dig Dis Sci 50 2005 1852 1856
93. T. Shimosegawa, K. Kume, A. Masamune SPINK1 gene mutations and pancreatitis in Japan J Gastroenterol Hepatol 21 Suppl 3 2006 S47 S51
94. A. Masamune, K. Kume, T. Shimosegawa Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis J Gastroenterol 42 Suppl 17 2007 135 140
95. C. Bertin, A.L. Pelletier, M.P. Vullierme Pancreas divisum is not a cause of pancreatitis by itself but acts as a partner of genetic mutations Am J Gastroenterol 107 2012 311 317
96. S. Paliwal, S. Bhaskar, K.R. Mani Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants Gut 2012 May 12 [Epub ahead of print]
97. R. Szmola, M. Sahin-Toth Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y Proc Natl Acad Sci U S A 104 2007 11227 11232
98. M.C. Chang, Y.T. Chang, S.C. Wei Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan Pancreatology 9 2009 287 292
99. P. Felderbauer, P. Hoffmann, H. Einwachter A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations BMC Gastroenterol 3 2003 34
100. P. Felderbauer, W. Klein, K. Bulut Mutations in the calcium-sensing receptor: a new genetic risk factor for chronic pancreatitis? Scand J Gastroenterol 41 2006 343 348
101. V. Muddana, J. Lamb, J.B. Greer Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol World J Gastroenterol 14 2008 4486 4491
102. G. Vezzoli, A. Terranegra, T. Arcidiacono R990G polymorphism of calcium-sensing receptor does produce a gain-of-function and predispose to primary hypercalciuria Kidney Int 71 2007 1155 1162
103. S. Pidasheva, L. D'Souza-Li, L. Canaff CASRdb: calcium-sensing receptor locus-specific database for mutations causing familial (benign) hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia Hum Mutat 24 2004 107 111
104. H. Pelli, R. Lappalainen-Lehto, A. Piironen Risk factors for recurrent acute alcohol-associated pancreatitis: a prospective analysis Scand J Gastroenterol 43 2008 614 621
105. I. Nordback, H. Pelli, R. Lappalainen-Lehto The recurrence of acute alcohol-associated pancreatitis can be reduced: a randomized controlled trial Gastroenterology 136 2009 848 855
106. G. Talamini, C. Bassi, M. Falconi Smoking cessation at the clinical onset of chronic pancreatitis and risk of pancreatic calcifications Pancreas 35 2007 320 326
107. P.G. Lankisch, N. Breuer, A. Bruns Natural history of acute pancreatitis: a long-term population-based study Am J Gastroenterol 104 2009 2797 2805 quiz 2806
108. J. Van Laethem, P. Robberecht, A. Resibois Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice Gastroenterology 110 1996 576 582
109. B.A. Neuschwander-Tetri, F.R. Burton, M.E. Presti Repetitive self-limited acute pancreatitis induces pancreatic fibrogenesis in the mouse Dig Dis Sci 45 2000 665 674
110. X. Deng, L. Wang, M.S. Elm Chronic alcohol consumption accelerates fibrosis in response to cerulein-induced pancreatitis in rats Am J Pathol 166 2005 93 106
111. G. Perides, X. Tao, N. West A mouse model of ethanol dependent pancreatic fibrosis Gut 54 2005 1461 1467
112. R.H. Duerr, K.D. Taylor, S.R. Brant A genome-wide association study identifies IL23R as an inflammatory bowel disease gene Science 314 2006 1461 1463
113. M. Cargill, S.J. Schrodi, M. Chang A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes Am J Hum Genet 80 2007 273 290
114. A. Barrie, J. Lamb, B. Sandhu et al. Susceptibility to alcoholic pancreatitis, but not sporadic pancreatitis, is significantly reduced by the IL23R R381Q gene variant Am J Gastroenterol 107 Supplement 1 2012 S103
115. Alcohol use and alcohol use disorders in the United States: main findings from the 2001-2002 National Epidemiological Survey on Alcohol and Related Conditions (NESARC) U.S. Alcohol Epidemiologic Data Reference Manual 8 2006 NIH Publication No. 05-5737
116. C.M. Van Itallie, J. Holmes, A. Bridges The density of small tight junction pores varies among cell types and is increased by expression of claudin-2 J Cell Sci 121 2008 298 305
117. S. Amasheh, N. Meiri, A.H. Gitter Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells J Cell Sci 115 2002 4969 4976
118. S. Merilainen, J. Makela, V. Anttila Acute edematous and necrotic pancreatitis in a porcine model Scand J Gastroenterol 43 2008 1259 1268
119. T. Sakaguchi, X. Gu, H.M. Golden Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha J Biol Chem 277 2002 21361 21370
120. J. Mankertz, M. Amasheh, S.M. Krug TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling Cell Tissue Res 336 2009 67 77
121. T. Suzuki, N. Yoshinaga, S. Tanabe Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium J Biol Chem 286 2011 31263 31271
122. J. Mankertz, B. Hillenbrand, S. Tavalali Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity Biochem Biophys Res Commun 314 2004 1001 1007
123. J. Van den Bossche, D. Laoui, Y. Morias Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumor-elicited macrophages in vivo Scand J Immunol 75 2012 588 598