Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-α. Role in regulating cell death and pancreatitis

Journal of Clinical Investigation

Volumn 100, Issue 7, 1997, Pages 1853-1862

  Gukovskaya, Anna S ^a   Gukovsky, Ilya ^b   Zaninovic, Vjekoslav ^b   Song, Moon ^b   Sandoval, Diana ^b   Gukovsky, Sofiya ^b   Pandol, Stephen J ^b  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

Apoptosis; NF B; Pancreatitis; TNF ; TNF receptor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ACINAR CELL; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ETIOLOGY; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

EID: 0030923560     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119714     Document Type: Article

References (56)

1. Cohen, M.C., and S. Cohen. 1996. Cytokine function: a study in biologic diversity. Am. J. Clin. Pathol. 105:589-598.
2. Balkwill, F.R., and F. Burke. 1996. The cytokine network. Immunol. Today. 10:299-303.
3. Beutler, B., and G.E. Grau. 1993. Tumor necrosis factor in the pathogenesis of infectious diseases. Crit. Care Med. 10:S423-S425.
4. Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Ann. Rev. Immunol. 10:411-452.
5. Tracey, K.J., and A. Cerami. 1994. Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Ann. Rev. Med. 45:491-503.
6. Baker, S.J., and E.P. Reddy. 1996. Transducers of life and death: TNF receptor superfamily and associated proteins. Oncogene. 12:1-9.
7. Bour, E.S., L.K. Ward, G.A. Cornman, and H.C. Isom. 1996. Tumor necrosis factor-alpha-induced apoptosis in hepatocytes in long-term culture. Am. J. Pathol. 148:485-495.
8. Beyaert, R., and W. Fiers. 1994. Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. What we do understand and what we do not. FEBS (Fed. Eur. Biochem. Soc.) Lett. 340:9-16.
9. Laster, S.N., J.G. Wood, and L.R. Goding. 1988. Tumor necrosis factor can induce both apoptotic and necrotic form of cell lysis. J. Immunol. 141:2629-2634.
10. Reid, T.R., F.M. Torti, and G.M. Ringold. 1989. Evidence for two mechanisms by which tumor necrosis factor kills cells. J. Biol. Chem. 264:4583-4589.
11. Woods, K.M., and S.K. Chapes. 1993. Three distinct cell phenotypes of TNF-induced cytotoxicity and their relationship to apoptosis. J. Leukocyte Biol. 53:37-44.
12. Dealtry, G.B., M.S. Naylor, W. Fiers, and F.R. Balkwill. 1987. DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon-γ. Eur. J. Immunol. 17:689-693.
13. Tartaglia, L.A., and D.V. Goeddel. 1942. Two TNF receptors. Immunol. Today. 13:151-153.
14. Brockhaus, M., H.J. Shoenfeld, E.J. Schlaeger, W. Hunziker, W. Lesslauer, and H. Loetscher. 1990. Identificalion of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies. Proc. Natl. Acad. Sci. USA. 87:3127-3131.
15. Espevik, T., M. Brockhaus, H. Loetsche, U. Nonstad, and R. Shalaby. 1990. Characterization of binding and biological effect of monoclonal antibodies against a human tumor necrosis factor receptor. J. Exp. Med. 171:415-126
16. Hohmann, H.P., M. Brockhaus, P.A. Haeuerle, R. Remy, R. Kolbeck, and A.P. van Loon. 1990. Fxpression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-κB. J. Biol. Chem. 265:22409-22417.
17. Larrick, J.W., and S.C. Wright. 1990. Cytotoxic mechanism of tumor necrosis factor-α. FASEB (Fed. Am. Soc. Exp. Biol.) J. 4:3215-3223.
18. Lewis, M., L.A. Tartaglia, A. Lee, G.L. Bennett, G.C. Rice, G.H.W. Wong, E.Y. Chen, and D.V. Goeddel. 1991. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. USA. 88:2830-2834.
19. Fiers, W. 1991. Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level. FEBS (Fed. Eur. Biochem. Soc.) Lett. 285:199-212.
20. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455.
21. Heller, R.A., and M. Krönke. 1994. Tumor necrosis factor receptor mediated signaling pathways. J. Cell Biol. 126:5-9.
22. Kern, P.A., M. Saghizadeh, J.M. Org, R.J. Bosch, R. Deem, and R. Simsolo. 1995. The expression of tumor necrosis factor in human adipose tissue. J. Clin. Invest. 95:2111-2119.
23. Saghizadeh, M., J.M. Org, W.T. Garvey, R.R. Henry, and P.A. Kern. 1996. The expression of TNFα by human muscle: Relationship to insulin resistance. J. Clin. Invest. 97:1111-1116.
24. Kapadia, S., J. Lee, G. Torre-Amione, H.H. Birdsall, T.S. Ma, and D.C. Mann. 1995. Tumor necrosis factor-α gene and protein expression in adult feline myocardium after endotoxin administration. J. Clin. Invest. 96:1042-1052.
25. Yamada, K., N. Takane, S. Otabe, C. Inada, M. Inoue, K. Nonaka. 1993. Pancreatic β-cell-selective production of TNFα induced by interleukin-1. Diabetes. 42:1026-1031.
26. Lieberman, A.P., P.M. Pitha, H.S. Shin, and M.L. Shin. 1989. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc. Natl. Acad. Sci. USA. 86:6348-6352.
27. Dolan, S., G. Campbell, G. McLuggage, M. Halliday, and B. Rowlands. 1994. Biphasic tumor necrosis factor release in experimental acute pancreatitis. Gut. 35:575. (Abstr.)
28. McKay, C., G. Gallagher, J.N. Baxter, and C.W. Imrie. 1994. Systemic complications in acute pancreatitis are associated with increased monocyte cytokine release. Gut. 35:575. (Abstr.)
29. Norman, J.G., M.D. Fink, and M.D. Franz. 1995. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression. Arch. Surg. 130: 966-970.
30. Grewal, H., M. Kotb, A.M.E. Din, M. Ohman, A. Salem, L. Gaber, and A. Gaber. 1994. Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage. Surgery. 115:213-221.
31. Hughes, C.B., H.P. Grewall, L.W. Gaber, M. Kotb, A.B. El-Din, L. Mann, and A.O. Gaber. 1996. Anti-TNFα therapy improves survival and ameliorates the pathophysiolgic sequelae in acute pancreatitis in the rat. Am. J. Surg. 171:274-280.
32. Tani, S., M. Otsuki, H. Itoh, M. Fujii, T. Nakamura, T. Oka, and S. Baba. 1987. Histologic and biochemical alterations in experimental acute pancreatitis induced by supramaximal caerulein stimulation. Int. J. Pancreatol. 2:337-348.
33. Sandoval, D., A. Gukovskaya, P. Reavey, S. Gukovsky, A. Sisk, P. Braquet, S. Pandol, and S. Poucell-Hatton. 1996. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology. 111:1081-1091.
34. Gukovskaya, A.S., S. Poucell-Hatton, T.J. Fitzsimmons, P.S. Perkins, V. Zaninovic, D. Sandoval, R. Rutherford, and S.J. Pandol. 1994. Apoptosis in experimental pancreatitis. Gastroenterology. 106:A295. (Abstr.)
35. Gukovskaya, A.S., P. Perkins, V. Zaninovic, D. Sandoval, R. Rutherford, T. Fitzsimmons, S.J. Pandol, and S. Poucell-Hatton. 1996. Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology. 110:875-884.
36. Kaiser, A.M., A.K. Saluja, A. Sengupta, M. Saluja, and M. Steer. 1995. Relationship between severity, necrosis, and apoptosis in five models of experimental pancreatitis. Am. J. Physiol. 269:C1295-C1304.
37. Gorelick, F.S., G. Adler, and H.F. Kern. 1943. Caerulein induced pancreatitis. In The Pancreas: Biology, Pathobiology and Disease. Raven Press, Ltd., New York. 501-526.
38. 4]bombesin-induced desensitization in dispersed acini from guinea pig pancreas. J. Biol. Chem. 257:12024-12029.
39. Aggawal, B.B., W.J. Kohr, P.E. Mass, B. Moffat, S.A. Spencer, W.J. Henzel, T.S. Bringman, G.E. Nedwin, D.V. Goeddel, and R.N. Harkins. 1985. Human tumor necrosis factor. Production, purification and characterization. J. Biol. Chem. 260:2345-2354.
40. Smith, R.A., and B. Corrado. 1987. The active form of tumor necrosis factor is a trimer. J. Biol. Chem. 262:6851-6854.
41. Han, J.H., C. Stratowa, and W.J. Rutter. 1987. Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning. Biochemistry. 26:1617-1625.
42. Dignam, J.D., R.M. Lebovitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
43. Burton, K. 1956. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62:315-322.
44. Espevik, T., and J. Nissen-Meyer. 1986. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J. Immunol. Methods. 95:99-105.
45. Beutler, B., and A. Cerami. 1986. Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature (Lond.). 320:584-588.
46. Hall, P.A., and N.R. Lemoine. 1992. Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas. J. Pathol. 166:97-103.
47. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:5463-5467.
48. Fesus, L., P.J.A. Davies, and M. Piacentini. 1991. Apoptosis: molecular mechanisms in programmed cell death. Eur. J. Cell Biol. 56:170-177.
49. Leist, M., F. Ganther, I. Bohlinger, P. German, G. Tiegs, and A. Wendel. 1994. Murine hepatocyte apoptosis in vitro and in vivo by TNF-α requires transcriptional arrest. J. Immunol. 153:1778-1787.
50. Formela, L.J., P.J. McLaughlin, B.F. Flanagan, S.N. Southern, T.E. Giles, I.F. McDicken, and A.N. Kingsworth. 1994. Demonstration of tumor necrosis factor in pancreatic acinar cells by in situ hybridization in a model of acute pancreatitis. Gut. 35:575. (Abstr.)
51. DeLisle, R.E., and C.D. Logsdon. 1990. Pancreatic acinar cells in culture: expression of acinar and ductal antigens in a growth related manner. Eur. J. Cell Biol. 51:64-95.
52. Grewal, H., A.M. Din, L. Gaber, M. Kotb, and A.O. Gaber. 1994. Amerlioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNFα polyclonal antibody. Am. J. Surgery. 167:213-219.
53. Hughes, C.B., L.W. Gaber, A.B.M. El-Din, H.P. Grewal, M. Kotb, L. Mann, and A.O. Gaber. 1990. Inhibition of TNFα improves survival in an experimental model of acute pancreatitis. Am. Surg. 62:8-13.
54. Norman, J.G., M.G. Franz, G.S. Fink, M.D. Messina, P.J. Fabri, W.R. Grower, and L.C. Carey. 1995. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade. Ann. Surg. 221:625-634.
55. Dusetti, N.J., E.M. Ortiz, G.V. Mallo, J.C. Dagorn, and J.L. Iovanna. 1995. Pancreatitis-associated protein I (PAP-I), an acute phase protein induced by cytokines. J. Biol. Chem. 270:22417-22421.
56. Zhou, W., B.A. Levine, and M.S. Olson. 1993. Platelet activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation. Am. J. Pathol. 142:1504-1512.