Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 5, 2015, Pages 693-708

  Wehinger, Sergio ^a,b   Ortiz, Rina ^a   Díaz, María Inés ^a   Aguirre, Adam ^a   Valenzuela, Manuel ^a   Llanos, Paola ^c   Mc Master, Christopher ^d,e   Leyton, Lisette ^a   Quest, Andrew F G ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD DE TALCA   (Chile)

^c UNIVERSITY OF CHILE   (Chile)

^d DALHOUSIE UNIVERSITY   (Canada)

^e DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Apoptosis; Beta cell; Caveolin 1; Palmitate; Reactive oxygen species; Tyrosine 14

Indexed keywords

ACETYLCYSTEINE; CAVEOLIN 1; CERAMIDE; GLUTAMIC ACID; OLEIC ACID; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; TYROSINE; TYROSINE 14; UNCLASSIFIED DRUG; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; HYDROGEN PEROXIDE; N-ACETYLSPHINGOSINE; OXIDIZING AGENT; PALMITIC ACID DERIVATIVE; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE; SCAVENGER; SPHINGOSINE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL ISOLATION; FLOW CYTOMETRY; LIPOGENESIS; MALE; MEMBRANE POTENTIAL; MIN6 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SITE DIRECTED MUTAGENESIS; STABLE TRANSFECTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; C57BL MOUSE; CELL SURVIVAL; CONFOCAL MICROSCOPY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; PANCREAS ISLET BETA CELL; PHOSPHORYLATION; TUMOR CELL LINE;

MURINAE;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CAVEOLIN 1; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; INSULIN-SECRETING CELLS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; OXIDANTS; PALMITATES; PHOSPHORYLATION; PYRIMIDINES; REACTIVE OXYGEN SPECIES; SPHINGOSINE; SRC-FAMILY KINASES; TYROSINE;

EID: 84922384549     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.12.021     Document Type: Article

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