Cysteine aggravates palmitate-induced cell death in hepatocytes

Life Sciences

Volumn 89, Issue 23-24, 2011, Pages 878-885

  Dou, Xiaobing ^a,b   Wang, Zhigang ^b,c   Yao, Tong ^a   Song, Zhenyuan ^b,c  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Cysteine; ER stress; HepG2; JNK; Palmitate

Indexed keywords

CYSTEINE; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LACTATE DEHYDROGENASE; MALONALDEHYDE; PALMITIC ACID; STRESS ACTIVATED PROTEIN KINASE;

ALCOHOL LIVER DISEASE; ALCOHOLIC STEATOHEPATITIS; ARTICLE; CELL DEATH; CELL STRAIN HEPG2; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LIPOTOXICITY; LIVER CELL; NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; SENSITIZATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL DEATH; CELL LINE; CYSTEINE; DRUG SYNERGISM; GLUTATHIONE; HEP G2 CELLS; HEPATOCYTES; HUMANS; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; PALMITATES; REACTIVE OXYGEN SPECIES;

EID: 81255157537     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.09.022     Document Type: Article

References (23)

1. Y. Akazawa, S. Cazanave, J.L. Mott, N. Elmi, S.F. Bronk, and S. Kohno Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis J Hepatol 52 2010 586 593
2. N. Alkhouri, L.J. Dixon, and A.E. Feldstein Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal Expert Rev Gastroenterol Hepatol 3 2009 445 451
3. F.J. Barreyro, S. Kobayashi, S.F. Bronk, N.W. Werneburg, H. Malhi, and G.J. Gores Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis J Biol Chem 282 2007 27141 27154 (Pubitemid 47501972)
4. J.M. Cacicedo, S. Benjachareowong, E. Chou, N.B. Ruderman, and Y. Ido Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide Diabetes 54 2005 1838 1845 (Pubitemid 40770775)
5. R. Cardin, A. D'Errico, M. Fiorentino, A. Cecchetto, R. Naccarato, and F. Farinati Hepatocyte proliferation and apoptosis in relation to oxidative damage in alcohol-related liver disease Alcohol Alcohol 37 2002 43 48 (Pubitemid 34173308)
6. A.A. Caro, and A.I. Cederbaum Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1 Mol Pharmacol 60 2001 742 752 (Pubitemid 32900256)
7. S.E. Choi, H.E. Kim, H.C. Shin, H.J. Jang, K.W. Lee, and Y.S. Kim Involvement of Ca2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death Mol Cell Endocrinol 272 2007 50 62
8. A.K. Elshorbagy, E. Nurk, C.G. Gjesdal, G.S. Tell, P.M. Ueland, and O. Nygård Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? Am J Clin Nutr 88 2008 738 746
9. M.K. Gaitonde A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids J Biochem 104 1967 627 633
10. J.L. Goldstein, S.K. Basu, and M.S. Brown Receptor-mediated endocytosis of low-density lipoproteins in cultured cells Methods Enzymol 98 1983 241 260 (Pubitemid 14219888)
11. X. Gu, K. Li, D.R. Laybutt, M.L. He, H.L. Zhao, and J.C. Chan Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells Life Sci 87 2010 724 732
12. S.H. Ibrahim, Y. Akazawa, S.C. Cazanave, S.F. Bronk, N.A. Elmi, and N.W. Werneburg Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis J Hepatol 54 2011 765 772
13. S.C. Kalhan, L. Guo, J. Edmison, S. Dasarathy, A.J. McCullough, and R.W. Hanson Plasma metabolomic profile in nonalcoholic fatty liver disease Metabolism 60 2011 404 413
14. J.E. Kim, S.E. Song, Y.W. Kim, J.Y. Kim, S.C. Park, and Y.K. Park Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase J Endocrinol 207 2010 35 44
15. T.A. Miller, N.K. LeBrasseur, G.M. Cote, M.P. Trucillo, D.R. Pimentel, and Y. Ido Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes Biochem Biophys Res Commun 336 2005 309 315 (Pubitemid 41253435)
16. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituricacid reaction Anal Biochem 95 1979 351 358 (Pubitemid 9194347)
17. M. Pascual, S.L. Valles, J. Renau-Piqueras, and C. Guerri Ceramide pathways modulate ethanol-induced cell death in astrocytes J Neurochem 87 2003 1535 1545 (Pubitemid 38020587)
18. K.T. Pfaffenbach, C.L. Gentile, A.M. Nivala, D. Wang, Y. Wei, and M.J. Pagliassotti Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death Am J Physiol Endocrinol Metab 298 2010 1027 1035
19. M. Valentina, M.P. Janet, P.S. Sally, W.F. Samuel, F.G. Jesse, and C.V. Maria Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease J Hepatol 53 2010 551 557
20. Y.M. Wang, S.Q. Peng, Q. Zhou, MWi Wang, C.H. Yan, and H.Y. Yang Depletion of intracellular glutathione mediates butenolide induced cytotoxicity in HepG2 cells Toxicol Lett 164 2006 231 238 (Pubitemid 43766795)
21. Y. Wei, D. Wang, F. Topczewski, and M.J. Pagliassotti Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells Am J Physiol Endocrinol Metab 291 2006 275 281
22. N. Yasushi, D.Y. Jamey, O.A. Jose, E.H. Michael, K.K. Joanne, and S. Gregory Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis J Biol Chem 284 2009 33425 33436
23. L. Zhang, L.C. Seitz, A.M. Abramczyk, and C. Chan Exp Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells Cell Res 316 2010 716 727