Caveolin-I enhances resveratrol-mediated cytotoxicity and transport in a hepatocellular carcinoma model

Journal of Translational Medicine

Volumn 7, Issue , 2009, Pages

  Yang, Hui Ling ^a   Chen, Wei Qiong ^a   Cao, Xuan ^a   Worschech, Andrea ^b,d,e   Du, Li Fen ^a   Fang, Wei Yi ^c   Xu, Yang Yan ^a   Stroncek, David F ^b   Li, Xin ^c   Wang, Ena ^b   Marincola, Francesco M ^b  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d GENELUX CORPORATION   (United States)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CAVEOLIN 1; CAVEOLIN 2; CAVEOLIN 3; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUORESCENT DYE; GREEN FLUORESCENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RESVERATROL; SHORT HAIRPIN RNA; TAMOXIFEN; ANGIOGENESIS INHIBITOR; STILBENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL TRANSPORT; CONTROLLED STUDY; CYTOTOXICITY TEST; DOSE RESPONSE; DRUG TRANSPORT; ENDOCYTOSIS; ENZYME ACTIVITY; HEPATOBLASTOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LIVER CELL CARCINOMA; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR VOLUME; UPREGULATION; ANIMAL; CELL DEATH; CELL SURVIVAL; DRUG EFFECT; DRUG POTENTIATION; GENE DELETION; GENETIC TRANSFECTION; LIVER TUMOR; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; REPORTER GENE; TUMOR CELL LINE;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CAVEOLIN 1; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SYNERGISM; ENDOCYTOSIS; GENES, REPORTER; HUMANS; LIVER NEOPLASMS; MICE; MICE, NUDE; SEQUENCE DELETION; STILBENES; TRANSFECTION;

EID: 65749103778     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-7-22     Document Type: Article

References (34)

1. Jang M Cai L Udeani GO Slowing KV Thomas CF Beecher CW et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science 1997, 275:218-220. 10.1126/science.275.5297.218 8985016
2. Burkitt MJ Duncan J Effects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage: Evidence for hydroxyl-radical scavenging and a novel, glutathione-sparing mechanism of action Arch Biochem Biophys 2000, 381:253-263. 10.1006/abbi.2000.1973 11032413
3. de la Lastra CA Villegas I Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications Mol Nutr Food Res 2005, 49:405-430. 10.1002/mnfr.200500022 15832402
4. Palamara AT Nencioni L Aquilano K De CG Hernandez L Cozzolino F et al. Inhibition of influenza A virus replication by resveratrol J Infect Dis 2005, 191:1719-1729. 10.1086/429694 15838800
5. Das DK Maulik N Resveratrol in cardioprotection: A therapeutic promise of alternative medicine Mol Interv 2006, 6:36-47. 10.1124/mi.6.1.7 16507749
6. Das S Das DK Resveratrol: A therapeutic promise for cardiovascular diseases Recent Patents Cardiovasc Drug Discov 2007, 2:133-138. 10.2174/ 157489007780832560
7. Ito T Akao Y Yi H Ohguchi K Matsumoto K Tanaka T et al. Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C Carcinogenesis 2003, 24:1489-1497. 10.1093/carcin/bgg105 12844481
8. Fulda S Debatin KM Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol Cancer Res 2004, 64:337-346. 10.1158/0008-5472.CAN-03-1656 14729643
9. Zhang Q Tang X Lu QY Zhang ZF Brown J Le AD Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells Mol Cancer Ther 2005, 4:1465-1474. 10.1158/1535-7163.MCT-05-0198 16227395
10. Chan WK Delucchi AB Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4 Life Sci 2000, 67:3103-3112. 10.1016/S0024-3205(00)00888-2 11125847
11. Tseng SH Lin SM Chen JC Su YH Huang HY Chen CK et al. Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats Clin Cancer Res 2004, 10:2190-2202. 10.1158/1078-0432.CCR-03-0105 15041740
12. Pozo-Guisado E Merino JM Mulero-Navarro S Lorenzo-Benayas MJ Centeno F varez-Barrientos A et al. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB Int J Cancer 2005, 115:74-84. 10.1002/ijc.20856 15688415
13. Szewczuk LM Lee SH Blair IA Penning TM Viniferin formation by COX-1: evidence for radical intermediates during co-oxidation of resveratrol J Nat Prod 2005, 68:36-42. 10.1021/np049702i 15679314
14. Tyagi A Singh RP Agarwal C Siriwardana S Sclafani RA Agarwal R Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells Carcinogenesis 2005, 26:1978-1987. 10.1093/ carcin/bgi165 15975956
15. Bhat KP Lantvit D Christov K Mehta RG Moon RC Pezzuto JM Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models Cancer Res 2001, 61:7456-7463. 11606380
16. Klinge CM Blankenship KA Risinger KE Bhatnagar S Noisin EL Sumanasekera WK et al. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells J Biol Chem 2005, 280:7460-7468. 10.1074/jbc.M411565200 15615701
17. Galluzzo P Caiazza F Moreno S Marino M Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation Endocr Relat Cancer 2007, 14:153-167. 10.1677/ERC-06-0020 17395984
18. Rejman J Conese M Hoekstra D Gene transfer by means of lipo- and polyplexes: Role of clathrin and caveolae-mediated endocytosis J Liposome Res 2006, 16:237-247. 10.1080/08982100600848819 16952878
19. Razani B Schlegel A Liu J Lisanti MP Caveolin-I, a putative tumour suppressor gene Biochem Soc Trans 2001, 29:494-499. 10.1042/BST0290494 11498016
20. Ho CC Huang PH Huang HY Chen YH Yang PC Hsu SM Up-regulated caveolin-I accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation Am J Pathol 2002, 161:1647-1656. 1850800 12414512
21. Liu P Rudick M Anderson RG Multiple functions of caveolin-I J Biol Chem 2002, 277:41295-41298. 10.1074/jbc.R200020200 12189159
22. Peterson TE Guicciardi ME Gulati R Kleppe LS Mueske CS Mookadam M et al. Caveolin-I can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway Arterioscler Thromb Vasc Biol 2003, 23:1521-1527. 10.1161/01.ATV.0000081743.35125.05 12816877
23. Duxbury MS Ito H Ashley SW Whang EE CEACAM6 cross-linking induces caveolin-I-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells J Biol Chem 2004, 279:23176-23182. 10.1074/jbc.M402051200 15047698
24. Graziani A Bricko V Carmignani M Graier WF Groschner K Cholesterol- and caveolin-rich membrane domains are essential for phospholipase A2-dependent EDHF formation Cardiovasc Res 2004, 64:234-242. 10.1016/ j.cardiores.2004.06.026 15485682
25. Bowers JL Tyulmenkov VV Jernigan SC Klinge CM Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta Endocrinology 2000, 141:3657-3667. 10.1210/en.141.10.3657 11014220
26. Yang H He S Quan Z Peng W Yan B Liu J et al. Small interfering RNA-mediated caveolin-I knockout on plasminogen activator inhibitor-I expression in insulin-stimulated human vascular endothelial cells Acta Biochim Biophys Sin (Shanghai) 2007, 39:224-233. 10.1111/ j.1745-7270.2007.00270.x 17342262
27. Xu YY Yang HL Tu J The construction, Identification and primary functional analysis of pcDNA3.I/NT-GFP-Caveolin-I and mutants plasmids Chin J Atheroscler 2006, 13:297-300.
28. Yang HL Jiang HJ Fang WY Xu YY Liao DF He FC High fidelity PCR with an off/on switch mediated by proofreading polymerases combining with phosphorothioate-modified primer Biochem Biophys Res Commun 2005, 328:265-272. 10.1016/j.bbrc.2004.12.159 15670779
29. Yang HL Xu YY Du LF Liu CH Zhao Q Wei WJ et al. Chemokine SR-PSOX/CXCLI6 expression in peripheral blood of patients with acute coronary syndrome Chin Med J (Engl) 2008, 121:112-117. 18272035
30. Quan Z Yang H Yang Y Yan B Cao R Wen G et al. Construction and functional analysis of a lentiviral expression vector containing a scavenger receptor (SR-PSOX) that binds uniquely phosphatidylserine and oxidized lipoprotein Acta Biochim Biophys Sin (Shanghai) 2007, 39:208-216. 10.1111/j.1745-7270.2007.00264.x 17342260
31. Yerian LM Anders RA Tretiakova M Hart J Caveolin and thrombospondin expression during hepatocellular carcinogenesis Am J Surg Pathol 2004, 28:357-364. 10.1097/00000478-200403000-00008 15104298
32. Torres VA Tapia JC Rodriguez DA Parraga M Lisboa P Montoya M et al. Caveolin-I controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin J Cell Sci 2006, 119:1812-1823. 10.1242/jcs.02894 16608879
33. Pakunlu RI Wang Y Tsao W Pozharov V Cook TJ Minko T Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense: Novel multicomponent delivery system Cancer Res 2004, 64:6214-6224. 10.1158/ 0008-5472.CAN-04-0001 15342407
34. Hazlehurst LA Argilagos RF Emmons M Boulware D Beam CA Sullivan DM et al. Cell adhesion to fibronectin (CAM-DR) influences acquired mitoxantrone resistance in U937 cells Cancer Res 2006, 66:2338-2345. 10.1158/0008-5472.CAN-05-3256 16489039