Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 6, 2014, Pages 887-896

  Risso, Valeria A ^a   Gavira, Jose A ^b   Gaucher, Eric A ^c   Sanchez Ruiz, Jose M ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Antibiotic degradation; Consensus proteins; Lactamases; Protein engineering; Protein stability; Resurrected proteins; Substrate promiscuity

Indexed keywords

AMINO ACID; BETA LACTAMASE; BETA LACTAMASE TEM 1; NUCLEOSIDE DIPHOSPHATE KINASE; PROTEIN VARIANT; BACTERIAL PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME DEGRADATION; EVOLUTIONARY RATE; LAST COMMON ANCESTOR; MUTATION; NONHUMAN; PHENOTYPIC VARIATION; PHYLOGENETIC TREE; PRECAMBRIAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN ENGINEERING; PROTEIN INDUCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; TEMPERATURE DEPENDENCE; THERMOSTABILITY; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENTEROBACTERIACEAE; ENZYME STABILITY; ENZYMOLOGY; GAMMAPROTEOBACTERIA; GENETICS; GRAM POSITIVE BACTERIUM; PHENOTYPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BETA-LACTAMASES; BIOCATALYSIS; CONSENSUS SEQUENCE; ENTEROBACTERIACEAE; ENZYME STABILITY; GAMMAPROTEOBACTERIA; GRAM-POSITIVE BACTERIA; MODELS, MOLECULAR; PHENOTYPE;

EID: 84900832991     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24575     Document Type: Article

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