Change in allosteric network affects binding affinities of PDZ domains: Analysis through perturbation response scanning

PLoS Computational Biology

Volumn 7, Issue 10, 2011, Pages

  Gerek, Z Nevin ^a   Ozkan, S Banu ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DYNAMICS;

ALLOSTERIC MECHANISMS; ALLOSTERIC REGULATION; ALLOSTERIC TRANSITION; BINDING AFFINITIES; BINDING-SITES; CELLULAR FUNCTION; DOMAIN ANALYSIS; INTRAMOLECULAR COMMUNICATION; MEAN SQUARE FLUCTUATION; PDZ DOMAINS;

BINDING SITES;

ALLOSTERISM; ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL FUNCTION; CONTROLLED STUDY; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PDZ DOMAIN; PERTURBATION RESPONSE SCANNING; PROCESS DEVELOPMENT; PROCESS MODEL; PROTEIN CONFORMATION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PHYSIOLOGY; REVIEW;

NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 13; PTPN13 PROTEIN, HUMAN;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; COMPUTATIONAL BIOLOGY; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PDZ DOMAINS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13; SIGNAL TRANSDUCTION;

EID: 80055066238     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002154     Document Type: Article

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