Conformational selection or induced fit? A critical appraisal of the kinetic mechanism

Biochemistry

Volumn 51, Issue 30, 2012, Pages 5894-5902

  Vogt, Austin D ^a   Di Cera, Enrico ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPROACH TO EQUILIBRIUM; BIOLOGICAL MACROMOLECULE; COMPETING MECHANISMS; CONFORMATIONAL ISOMERIZATION; CONFORMATIONAL SELECTION; CONFORMATIONAL TRANSITIONS; GLUCOKINASE; INDUCED FIT; KINETIC MECHANISM; KINETIC PROPERTIES; LIGAND BINDING; LIGAND CONCENTRATION; LIGAND DISSOCIATION; LIGAND RECOGNITION; RAPID EQUILIBRIUM; TWO-STEP MECHANISMS;

DISSOCIATION;

LIGANDS;

ENZYME PRECURSOR; GLUCOKINASE; GLUCOSE; PRETHROMBIN 2; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CONFORMATION; CONFORMATION SELECTION; DISSOCIATION; ENZYME CONFORMATION; ISOMERIZATION; LIGAND BINDING; MATHEMATICAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION;

GLUCOKINASE; GLUCOSE; KINETICS; LIGANDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTHROMBIN; THROMBIN;

KOBUS;

EID: 84864462749     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3006913     Document Type: Article

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