Structural changes involved in protein binding correlate with intrinsic motions of proteins in the unbound state

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 52, 2005, Pages 18908-18913

  Tobi, Dror ^a   Bahar, Ivet ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Elastic network models; Induced fit; Lock and key mechanism; Preexisting equilibrium; Protein protein interactions

Indexed keywords

ACTIN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; CYCLINE; DEOXYRIBONUCLEASE I; HLA A2 ANTIGEN; PROTEIN LIR 1; PROTEIN P16INK4A; RECEPTOR; UNCLASSIFIED DRUG;

ANISOTROPY; ARTICLE; CONFORMATIONAL TRANSITION; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

ACTINS; ALLOSTERIC REGULATION; ANIMALS; ANISOTROPY; BINDING SITES; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLINS; DEOXYRIBONUCLEASE I; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MODELS, STATISTICAL; MOLECULAR CONFORMATION; NORMAL DISTRIBUTION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEINS; THERMODYNAMICS;

EID: 30044434744     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0507603102     Document Type: Article

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