The evolutionary origins of detoxifying enzymes: The mammalian serum paraoxonases (PONs) relate to bacterial homoserine lactonases

Journal of Biological Chemistry

Volumn 288, Issue 33, 2013, Pages 23914-23927

  Bar Rogovsky, Hagit ^a   Hugenmatter, Adrian ^a,b   Tawfik, Dan S ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b Roche Glycart   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DETOXIFYING ENZYMES; DIFFERENT SUBSTRATES; EVOLUTIONARY HISTORY; EVOLUTIONARY ORIGIN; HOMOSERINE; SPECIFICITY PROFILE;

BODY FLUIDS; ENZYMES; QUENCHING;

MAMMALS;

ARYLDIALKYLPHOSPHATASE; N ACYLHOMOSERINE LACTONE; PONX OCCAL PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; INNATE IMMUNITY; MOLECULAR EVOLUTION; NONHUMAN; PHYLOGENETIC TREE; PRIORITY JOURNAL; QUORUM SENSING; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

DIRECTED EVOLUTION; ENZYMES; EVOLUTION; GENOMIC INSTABILITY; XENOBIOTICS;

4-BUTYROLACTONE; AMINO ACID SEQUENCE; ANIMALS; ARYLDIALKYLPHOSPHATASE; BACTERIA; CARBOXYLIC ESTER HYDROLASES; EVOLUTION, MOLECULAR; GENETIC VARIATION; HUMANS; HYDROLYSIS; KINETICS; MAMMALS; METABOLIC DETOXICATION, DRUG; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; QUORUM SENSING; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

EID: 84882392687     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.427922     Document Type: Article

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