Lupiwighteone induces cell cycle arrest and apoptosis and activates the Nrf2/ARE pathway in human neuroblastoma cells

Biomedicine and Pharmacotherapy

Volumn 69, Issue , 2015, Pages 153-161

  Ren, Jie ^a   Yang, Jie ^a   Xu, Yuanyuan ^a   Huang, Qianhui ^a   Yang, Meng ^a   Hu, Kun ^a  

^a CHANGZHOU UNIVERSITY   (China)

Author keywords

Apoptosis; Lupiwighteone; Nrf2

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYTOCHROME C; ISOFLAVONE DERIVATIVE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LUPIWIGHTEONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROCASPASE 9; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; NFE2L2 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME PHOSPHORYLATION; FLUORESCENCE MICROSCOPY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROBLASTOMA CELL; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANTIOXIDANT RESPONSIVE ELEMENT; CELL CYCLE CHECKPOINT; CELL NUCLEUS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENETICS; INTRACELLULAR SPACE; METABOLISM; NEUROBLASTOMA; PATHOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE;

ANTIOXIDANT RESPONSE ELEMENTS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; INTRACELLULAR SPACE; ISOFLAVONES; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEUROBLASTOMA; NF-E2-RELATED FACTOR 2; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84922257283     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2014.11.016     Document Type: Article

References (42)

1. Song J.L., Lin H., Ju C.X., Zhang J.Y., Ge Y.L., Wang Y. Isatin inhibits proliferation and induces apoptosis of SH-SY5Y neuroblastoma cells in vitro and in vivo. Eur J Pharmacol 2013, 702:235-241.
2. Andoh T., Chock P.B., Chiueh C.C. The roles of thioredoxin in protection against oxidative stress-induced apoptosis in SH-SY5Y cells. J Biol Chem 2002, 277:9655-9660.
3. Parada E., Egea J., Romero A., Del B.L., Garcia A.G., Lopez M.G. Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via alpha7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway. Free Radic Biol Med 2010, 49:1815-1821.
4. Yang W., Tiffany-Castiglioni E., Koh H.C., Son I.H. Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. Toxicol Lett 2009, 191:203-210.
5. Hou Q., Cymbalyuk E., Hsu S.C., Xu M., Hsu Y.T. Apoptosis modulatory activities of transiently expressed Bcl-2: roles in cytochrome c release and Bax regulation. Apoptosis 2003, 8:617-629.
6. Won S.J., Chung K.S., Ki Y.S., Choi J.H., Cho W.J., Lee K.T. CWJ-081, a novel 3-arylisoquinoline derivative, induces apoptosis in human leukemia HL-60 cells partially involves reactive oxygen species through c-Jun NH2-terminal kinase pathway. Bioorg Med Chem Lett 2010, 20:6447-6451.
7. Zhao Y.Y., Shen X.F., Chao X., Ho C.C., Cheng X.L., Zhang Y.M., et al. Ergosta-4,6,8(14),22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Biochim Biophys Acta 2011, 1810:384-390.
8. Dewson G., Kluck R.M. Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis. J Cell Sci 2009, 122:2801-2808.
9. Abdel-Fattah A.M., Amira M., Helmy W.A., Esawy M.A. Antitumor and antioxidant activities of levan and its derivative from the isolate Bacillus subtilis NRC1aza. Carbohyd Polym 2012, 89:314-322.
10. Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., Itoh K., Wakabayashi N., Katoh Y., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A 2002, 99:11908-11913.
11. Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J.D., et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 1999, 13:76-86.
12. Motohashi H., Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 2004, 10:549-557.
13. Kundu J., Kim D.H., Kundu J.K., Chun K.S. Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKa as upstream targets. Food Chem Toxicol 2014, 65:18-26.
14. Itoh K., Mimura J., Yamamoto M. Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxid Redox Signal 2010, 13:1665-1678.
15. Lee J.S., Surh Y.J. Nrf2 as a novel molecular target for chemoprevention. Cancer Lett 2005, 224:171-184.
16. Zheng L., Wang X.L., Luo W.J., Zhan Y.Z., Zhang Y.M. Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells. Food Chem Toxicol 2013, 58:332-339.
17. Kampkötter A., Chovolou Y., Kulawik A., Röhrdanz E., Weber N., Proksch P., et al. Isoflavone daidzein possesses no antioxidant activities in cell-free assays but induces the antioxidant enzyme catalase. Nutr Res Rev 2008, 28:620-628.
18. Al-Maharik N., Botting N.P. Synthesis of lupiwighteone via a para-Claisen-Cope rearrangement. Tetrahedron 2003, 59:4177-4181.
19. Cottet-Rousselle C., Ronot X., Leverve X., Mayol J.F. Cytometric assessment of mitochondria using fluorescent probes. Cytometry A 2011, 79:405-425.
20. Ly J.D., Grubb D.R., Lawen A. The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis 2003, 8:115-128.
21. Zhou P.H., Liu S.Q., Peng H. The effect of hyaluronic acid on IL-1beta-induced chondrocyte apoptosis in a ratmodel of osteoarthritis. J Orthop Res 2008, 6:1643-1648.
22. Liu Y.Y., Wang W., Fang B., Ma F.Y., Zheng Q., Deng P.Y., et al. Antitumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. Eur J Pharmacol 2013, 698:95-102.
23. Zhao C.R., Gao Z.H., Qu X.J. Nrf2-ARE signaling pathway and natural products for cancer chemoprevention. Cancer Epidemiol 2010, 34:523-533.
24. Kundu J., Kim D.H., Kundu J.K., Chun K.S. Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKa as upstream targets. Food Chem Toxicol 2004, 65:18-26.
25. Wang X.J., Li Y.Y., Luo L., Wang H.Y., Chi Z.X., Xin A., et al. Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs. Free Radic Biol Med 2014, 70:68-77.
26. Zhang X.Y., Zhao X.F., Ma Z.J. PYDDT, a novel phase 2 enzymes inducer, activates Keap1-Nrf2 pathway via depleting the cellular level of glutathione. Toxicol Lett 2010, 199:93-101.
27. Chan K.T., Meng F.Y., Li Q., Ho C.Y., Lam T.S., To Y., et al. Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration. Cancer Lett 2010, 294:24-118.
28. Shen J.K., Du H.P., Yang M., Wang Y.G., Jin J. Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. Ann Hematol 2009, 88:52-743.
29. Gopinathan L., Ratnacaram C.K., Kaldis P. Established and novel Cdk/cyclin complexes regulating the cell cycle and development. Results Probl Cell Differ 2011, 53:365-389.
30. Malumbres M. Revisiting the "Cdk-centric" view of the mammalian cell cycle. Cell Cycle 2005, 4:206-210.
31. Kim J.K., Diehl J.A. Nuclear cyclin D1: an oncogenic driver in human cancer. J Cell Physiol 2009, 220:292-296.
32. Lewis C.W., Taylor R.G., Kubara P.M., Marshal K., Meijer L., Golsteyn R. A western blot assay to measure cyclin dependent kinase activity in cells or in vitro without the use of radioisotopes. FEBS Lett 2013, 587:3089-3095.
33. Li L.W., Lu N., Dai Q.S., Wei L.B., Zhao Q., Li Z.Y., et al. GL-V9, a newly synthetic flavonoid derivative, induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol 2011, 670:13-21.
34. Tao L.T., Fu R., Wang X.P., Yao J., Zhou Y.X., Dai Q., et al. LL-202, a newly synthesized flavonoid, inhibits tumor growth viainducing G2/M phase arrest and cell apoptosis in MCF-7 human breast cancer cells in vitro and in vivo. Toxicol Lett 2014, 228:1-12.
35. Chen G.C., Zhang P.Y., Huang T.T., Yu W.Q., Lin J., Li P., et al. Polysaccharides from Rhizopus nigricans mycelia induced apoptosis and G2/M arrest in BGC-823 cells. Carbohydr Polym 2013, 97:800-808.
36. Kang N., Wang M.M., Wang Y.H., Zhang Z.N., Cao H.R., Lv Y.H., et al. Tetrahydrocurcumin induces G2/M cell cycle arrest and apoptosis involving p38 MAPK activation in human breast cancer cells. Food Chem Toxicol 2014, 67:193-200.
37. Yang X.G., Bao Y.L., Huang Y.X., Sun L.G., Zhang Y.W., Yu C.L., et al. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol 2012, 695:27-33.
38. Zhou D.N., Wei A.H., Cao C., Ruan J.L. DICO, a novel nonaromatic B-ring flavonoid, induces G2/M cell cycle arrest and apoptosis in human hepatoma cells. Food Chem Toxicol 2013, 57:322-329.
39. Kurokawa M., Kornbluth S. Caspases and kinases in a death grip. Cell 2009, 138:838-854.
40. Jung E.B., Lee C.S. Baicalein attenuates proteasome inhibition-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways. Eur J Pharmacol 2014, 730:116-124.
41. Bennett L.L., Rojas S., Seefeldt T. Role of antioxidants in the prevention of cancer. J Exp Clin Med 2012, 4:215-222.
42. Regoli F., Giuliani M.E. Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms. Mar Environ Res 2014, 93:106-117.