CWJ-081, a novel 3-arylisoquinoline derivative, induces apoptosis in human leukemia HL-60 cells partially involves reactive oxygen species through c-Jun NH2-terminal kinase pathway

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6447-6451

  Won, So Jung ^a   Chung, Kyung Sook ^a   Ki, Yo Sook ^a   Choi, Jung Hye ^a   Cho, Won Jea ^b   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

3 (6 Ethyl benzo 1,3 dioxol 5 yl) 7,8 dimethoxy 2 methyl 2H isoquinolin 1 one; Apoptosis; JNK; ROS

Indexed keywords

3 (6 ETHYL BENZO[1,3]DIOXOL 5 YL) 7,8 DIMETHOXY 2 METHYL 2H ISOQUINOLIN 1 ONE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 8; CASPASE 9; CWJ 081; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLSERINE; PROTEIN BCL 2; PROTEIN C JUN; QUINOLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STIMULATION; CELL STRAIN HL 60; CELL STRAIN K 562; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL;

APOPTOSIS; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; ISOQUINOLINES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES;

EID: 77958029943     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.078     Document Type: Article

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