Baicalein attenuates proteasome inhibition-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways

European Journal of Pharmacology

Volumn 730, Issue 1, 2014, Pages 116-124

  Jung, Eun Byul ^a   Lee, Chung Soo ^a  

^a Chung Ang University   (South Korea)

Author keywords

Apoptosis related proteins; Baicalein; Differentiated PC12 cells; Proteasome inhibition; Protection

Indexed keywords

ACETYLCYSTEINE; BAICALEIN; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; GLUTATHIONE; MG 115; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SURVIVIN; TROLOX C; UNCLASSIFIED DRUG; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CARBOBENZOXY-LEUCYL-LEUCYL-NORVALINAL; FLAVANONE DERIVATIVE; LEUPEPTIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NERVE CELL NECROSIS; NONHUMAN; PC12 CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN SECRETION; RAT; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; DRUG EFFECTS; METABOLISM;

ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 8; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; FLAVANONES; GLUTATHIONE; LEUPEPTINS; MITOCHONDRIA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; RATS; REACTIVE OXYGEN SPECIES;

EID: 84896551695     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.02.039     Document Type: Article

References (48)

1. J.S. Armstrong Mitochondria: a target for cancer therapy Br. J. Pharmacol. 147 2006 239 248 (Pubitemid 43214681)
2. A. Berthier, S. Lemaire-Ewing, C. Prunet, S. Monier, A. Athias, G. Bessede, J.P. Pais de Barros, A. Laubriet, P. Gambert, G. Lizard, and D. Neel Involvement of a calcium-dependent dephosphorylation of BAD associated with the localization of Trpc-1 within lipid rafts in 7-ketocholesterol-induced THP-1 cell apoptosis Cell Death Differ. 11 2004 897 905 (Pubitemid 39139748)
3. U. Bonuccelli, and P. Del Dotto New pharmacological horizons in the treatment of Parkinson disease Neurology 67 7 Suppl 2 2006 S30 S38
4. A. Camins, M. Pallas, and J.S. Silvestre Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches Methods Find Exp. Clin. Pharmacol. 30 2008 43 65 (Pubitemid 351397455)
5. J.I. Chao, W.C. Su, and H.F. Liu Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT Mol. Cancer Ther. 6 2007 3039 3048
6. F. Chen, W. Wang, and W.S. El-Deiry Current strategies to target p53 in cancer Biochem. Pharmacol. 80 2010 724 730
7. J.E. Chipuk, and D.R. Green Dissecting p53-dependent apoptosis Cell Death Differ. 13 2006 994 1002
8. K.W. Chong, M.J. Chen, E.S. Koay, B.S. Wong, A.Y. Lee, F. Russo-Marie, and N.S. Cheung Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury Neurosci. Lett. 485 2010 129 133
9. M.L. Circu, and T.Y. Aw Glutathione and apoptosis Free Radic. Res. 42 2008 689 706
10. X.S. Cui, Y.J. Jeong, H.Y. Lee, S.H. Cheon, and N.H. Kim Fetal bovine serum influences apoptosis and apoptosis-related gene expression in porcine parthenotes developing in vitro Reproduction 127 2004 125 130
11. K.P. Das, T.M. Freudenrich, and W.R. Mundy Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures Neurotoxicol. Teratol. 26 2004 397 406 (Pubitemid 38534472)
12. J. Emerit, M. Edeas, and F. Bricaire Neurodegenerative diseases and oxidative stress Biomed. Pharmacother. 58 2004 39 46 (Pubitemid 38117047)
13. R. Franco, and J.A. Cidlowski SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis J. Biol. Chem. 281 2006 29542 29557 (Pubitemid 44536962)
14. R. Franco, and J.A. Cidlowski Apoptosis and glutathione: beyond an antioxidant Cell Death Differ. 16 2009 1303 1314
15. W. Fu, H. Luo, S. Parthasarathy, and M.P. Mattson Catecholamines potentiate amyloid β-peptide neurotoxicity: involvement of oxidative stress, mitochondrial dysfunction, and perturbed calcium homeostasis Neurobiol. Dis. 5 1998 229 243 (Pubitemid 28519153)
16. K. Gasiorowski, E. Lamer-Zarawska, J. Leszek, K. Parvathaneni, B.B. Yendluri, Z Błach-Olszewska, and G. Aliev Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? CNS Neurol. Disord. Drug Targets 10 2011 184 191
17. C.J. Hsieh, K. Hall, T. Ha, C. Li, G. Krishnaswamy, and D.S. Chi Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway Clin. Mol. Allerg. 5 2007 5
18. W. Hu, and J.J. Kavanagh Anticancer therapy targeting the apoptotic pathway Lancet Oncol. 4 2003 721 729 (Pubitemid 37527207)
19. W.H. Huang, A.R. Lee, and C.H. Yang Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI Biosci. Biotechnol. Biochem. 70 2006 2371 2380
20. Z. Jin, and W.S. El-Deiry Overview of cell death signaling pathways Cancer Biol. Ther. 4 2005 139 163 (Pubitemid 41351311)
21. T. Kadota, T. Yamaai, Y. Saito, Y. Akita, S. Kawashima, K. Moroi, N. Inagaki, and K. Kadota Expression of dopamine transporter at the tips of growing neurites of PC12 cells J. Histochem. Cytochem. 44 1996 989 996 (Pubitemid 26293370)
22. P.Y. Lam, and E. Cadenas Compromised proteasome degradation elevates neuronal nitric oxide synthase levels and induces apoptotic cell death Arch. Biochem. Biophys. 478 2008 181 186
23. R. Layfield, J. Lowe, and L. Bedford The ubiquitin-proteasome system and neurodegenerative disorders Essays Biochem. 41 2005 157 171 (Pubitemid 41500977)
24. A. Lebeau, F. Esclaire, W. Rostène, and D. Pélaprat Baicalein protects cortical neurons from ß-amyloid (25-35) induced toxicity Neuroreport 12 2001 2199 2202 (Pubitemid 32646272)
25. M. Li-Weber New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin Baicalein aicalin Cancer Treat. Rev. 35 2009 57 68
26. Y.C. Li, H.J. Lin, J.H. Yang, J.S. Yang, H.C. Ho, S.J. Chang, T.C. Hsai, H.F. Lu, A.C. Huang, and J.G. Chung Baicalein-induced apoptosis via endoplasmic reticulum stress through elevations of reactive oxygen species and mitochondria dependent pathway in mouse-rat hybrid retina ganglion cells (N18) Neurochem. Res. 34 2009 418 429
27. L. Lindenboim, J. Yuan, and R. Stein Bcl-xS and Bax induce different apoptotic pathways in PC12 cells Oncogene 19 2000 1783 1793 (Pubitemid 30200984)
28. 2-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38MAPK pathway Free Radic. Biol. Med. 53 2012 183 193
29. C. Liu, J. Wu, K. Xu, F. Cai, J. Gu, L. Ma, and J. Chen Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway J. Neurochem. 112 2010 1500 1512
30. L.M. McClusky Fetal bovine serum simultaneously stimulates apoptosis and DNA synthesis in premeiotic stages of spermatogenesis in spiny dogfish (Squalus acanthias) in vitro: modulation by androgen and spermatogenic activity status Apoptosis 13 2008 649 658
31. B. Mignotte, and J.L. Vayssière Mitochondria and apoptosis Eur. J. Biochem. 252 1998 1 15 (Pubitemid 28089952)
32. F. Misiti, F. Orsini, M.E. Clementi, W. Lattanzi, B. Giardina, and F. Michetti Mitochondrial oxygen consumption inhibition importance for TMT-dependent cell death in undifferentiated PC12 cells Neurochem. Int. 52 2008 1092 1099
33. H. Miwa, T. Kubo, A. Suzuki, K. Nishi, and T. Kondo Retrograde dopaminergic neuron degeneration following intrastriatal proteasome inhibition Neurosci. Lett. 380 2005 93 98 (Pubitemid 40602336)
34. D.J. Moore, V.L. Dawson, and T.M. Dawson Role for the ubiquitin-proteasome system in Parkinson′s disease and other neurodegenerative brain amyloidoses Neuromol. Med. 4 2003 95 108 (Pubitemid 37315188)
35. M. Moslehi, A. Meshkini, and R. Yazdanparast Flavonoid baicalein modulates H2O2-induced mitogen-activated protein kinases activation and cell death in SK-N-MC cells Cell. Mol. Neurobiol. 32 2012 549 560
36. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63 (Pubitemid 14203433)
37. M. Ott, V. Gogvadze, S. Orrenius, and B. Zhivotovsky Mitochondria, oxidative stress and cell death Apoptosis 12 2007 913 922 (Pubitemid 46653300)
38. L. Papa, E. Gomes, and P. Rockwell Reactive oxygen species induced by proteasome inhibition in neuronal cells mediate mitochondrial dysfunction and a caspase-independent cell death Apoptosis 12 2007 1389 1405 (Pubitemid 46988276)
39. L. Petrucelli, and T.M. Dawson Mechanism of neurodegenerative disease: role of the ubiquitin proteasome system Ann. Med. 36 2004 315 320 (Pubitemid 38789286)
40. P. Rong, A.M. Bennie, W.R. Epa, and G.L. Barrett Nerve growth factor determines survival and death of PC12 cells by regulation of the bcl-x, bax, and caspase-3 genes J. Neurochem. 72 1999 2294 2300 (Pubitemid 29242179)
41. J.X. Song, M.Y. Choi, K.C. Wong, W.W. Chung, S.C. Sze, T.B. Ng, and K.Y. Zhang Baicalein antagonizes rotenone-induced apoptosis in dopaminergic SH-SY5Y cells related to Parkinsonism Chin. Med. 7 2012 1
42. J. Suh, Y.A. Lee, and B.J. Gwag Induction and attenuation of neuronal apoptosis by proteasome inhibitors in murine cortical cell cultures J. Neurochem. 95 2005 684 694 (Pubitemid 41567161)
43. F. Sun, V. Anantharam, D. Zhang, C. Latchoumycandane, A. Kanthasamy, and A.G. Kanthasamy Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models Neurotoxicology 27 2006 807 815 (Pubitemid 44232996)
44. F. Sun, A. Kanthasamy, C. Song, Y. Yang, V. Anantharam, and A.G. Kanthasamy Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation J. Cell. Mol. Med. 12 2008 2467 2481
45. W.G. Tatton, R.M.E. Chalmers-Redman, W.J.H. Ju, M. Mammen, G.W. Carlile, A.W. Pong, and N.A. Tatton Propargylamines induce antiapoptotic new protein synthesis in serum-and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells J. Pharmacol. Exp. Ther. 301 2002 753 764 (Pubitemid 34429993)
46. R.J. van Klaveren, P.H.M. Hoet, J.L. Pype, M. Demedts, and B. Nemery Increase in γ-glutamyltransferase by glutathione depletion in rat type II pneumocytes Free Radic. Biol. Med. 22 1997 525 534 (Pubitemid 27020127)
47. Z. Zhang, W. Cui, G. Li, S. Yuan, D. Xu, M.P. Hoi, Z. Lin, J. Dou, Y. Han, and S.M. Lee Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways J. Agric. Food Chem. 60 2012 8171 8182
48. B. Zhivotovsky, and S. Orrenius Cell death mechanisms: cross-talk and role in disease Exp. Cell Res. 316 2010 1374 1383