DICO, a novel nonaromatic B-ring flavonoid, induces G2/M cell cycle arrest and apoptosis in human hepatoma cells

Food and Chemical Toxicology

Volumn 57, Issue , 2013, Pages 322-329

  Zhou, Daonian ^a,b   Wei, Anhua ^c   Cao, Cheng ^a   Ruan, Jinlan ^c  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^b Mayinglong Pharmaceutical Group   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Cell cycle; Flavonoid; Mitochondria; Reactive oxygen species

Indexed keywords

5,7 DIHYDROXY 2 (1,2 ISOPROPYLDIOXY 4 OXO CYCLOHEX 5 ENYL)CHROMEN 4 ONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CDC25C PROTEIN; CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; FLAVONOID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; ENZYME ACTIVATION; ENZYME RELEASE; G2 PHASE CELL CYCLE CHECKPOINT; HEPATOMA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASES; CYCLIN A; CYCLIN B1; DOSE-RESPONSE RELATIONSHIP, DRUG; FERNS; FLAVONOIDS; G2 PHASE CELL CYCLE CHECKPOINTS; HEP G2 CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES;

EID: 84877330683     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.03.032     Document Type: Article

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