메뉴 건너뛰기




Volumn 22, Issue 5, 2015, Pages 424-448

The therapeutic potential of cystathionine β-Synthetase/hydrogen sulfide inhibition in cancer

Author keywords

[No Author keywords available]

Indexed keywords

AMINOOXYACETIC ACID; CYSTATHIONINE BETA SYNTHASE; ENZYME INHIBITOR; HYDROGEN SULFIDE; ANTINEOPLASTIC AGENT;

EID: 84921911299     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2014.5933     Document Type: Review
Times cited : (208)

References (149)
  • 1
    • 0029876402 scopus 로고    scopus 로고
    • The possible role of hydrogen sulfide as an endogenous neuromodulator
    • Abe K and Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16: 1066-1071, 1996.
    • (1996) J Neurosci , vol.16 , pp. 1066-1071
    • Abe, K.1    Kimura, H.2
  • 2
    • 78650387370 scopus 로고    scopus 로고
    • The homocysteine hypothesis: Still relevant to the prevention and treatment of cardiovascular disease?
    • Abraham JM and Cho L. The homocysteine hypothesis: still relevant to the prevention and treatment of cardiovascular disease? Cleve Clin J Med 77: 911-918, 2010.
    • (2010) Cleve Clin J Med , vol.77 , pp. 911-918
    • Abraham, J.M.1    Cho, L.2
  • 3
    • 45749150751 scopus 로고    scopus 로고
    • Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia
    • Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, and Ishii I. Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. Hum Mol Genet 17: 1994-2005, 2008.
    • (2008) Hum Mol Genet , vol.17 , pp. 1994-2005
    • Akahoshi, N.1    Kobayashi, C.2    Ishizaki, Y.3    Izumi, T.4    Himi, T.5    Suematsu, M.6    Ishii, I.7
  • 8
    • 79952280621 scopus 로고    scopus 로고
    • Hydrogen sulfide gas has cell growth regulatory role
    • Baskar R and Bian J. Hydrogen sulfide gas has cell growth regulatory role. Eur J Pharmacol 656: 5-9, 2011.
    • (2011) Eur J Pharmacol , vol.656 , pp. 5-9
    • Baskar, R.1    Bian, J.2
  • 11
    • 84879539172 scopus 로고    scopus 로고
    • Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxiainducible factor-1a and vascular endothelial growth factor-dependent angiogenesis
    • Bir SC, Kolluru GK, McCarthy P, Shen X, Pardue S, Pattillo CB, and Kevil CG. Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxiainducible factor-1a and vascular endothelial growth factor-dependent angiogenesis. J Am Heart Assoc 1:-004093, 2012.
    • (2012) J Am Heart Assoc , vol.1 , pp. 004093
    • Bir, S.C.1    Kolluru, G.K.2    McCarthy, P.3    Shen, X.4    Pardue, S.5    Pattillo, C.B.6    Kevil, C.G.7
  • 12
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, and Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J Am Med Assoc 274: 1049-1057, 1995.
    • (1995) J Am Med Assoc , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 13
    • 77955065696 scopus 로고    scopus 로고
    • Hydrogen sulfide induces human colon cancer cell proliferation: Role of akt erk and p21
    • Cai WJ, Wang MJ, Ju LH, Wang C, and Zhu YC. Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21. Cell Biol Int 34: 565-572, 2010.
    • (2010) Cell Biol Int , vol.34 , pp. 565-572
    • Cai, W.J.1    Wang, M.J.2    Ju, L.H.3    Wang, C.4    Zhu, Y.C.5
  • 14
    • 34548379105 scopus 로고    scopus 로고
    • The novel proangiogenic effect of hydrogen sulfide is dependent on akt phosphorylation
    • Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, and Zhu YC. The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovasc Res 76: 29-40, 2007.
    • (2007) Cardiovasc Res , vol.76 , pp. 29-40
    • Cai, W.J.1    Wang, M.J.2    Moore, P.K.3    Jin, H.M.4    Yao, T.5    Zhu, Y.C.6
  • 16
    • 85002634765 scopus 로고    scopus 로고
    • Cysthionine-b-synthetase inhibition in combination with standard-chemotherapy decreases colorectal cancer metastasis to the liver
    • Chao C, Bohannon FJ, Mrazek A, Coletta C, Szabo C, Hellmich MR. Cysthionine-b-synthetase inhibition in combination with standard-chemotherapy decreases colorectal cancer metastasis to the liver. Nitric Oxide 39: S21, 2014.
    • (2014) Nitric Oxide , vol.39 , pp. S21
    • Chao, C.1    Bohannon, F.J.2    Mrazek, A.3    Coletta, C.4    Szabo, C.5    Hellmich, M.R.6
  • 18
    • 84883553253 scopus 로고    scopus 로고
    • Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic jurkat cells and modulates b-catenin expression
    • Chattopadhyay M, Nath N, Kodela R, Sobocki T, Metkar S, Gan ZY, and Kashfi K. Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic Jurkat cells and modulates b-catenin expression. Leuk Res 37: 1302-1308, 2013.
    • (2013) Leuk Res , vol.37 , pp. 1302-1308
    • Chattopadhyay, M.1    Nath, N.2    Kodela, R.3    Sobocki, T.4    Metkar, S.5    Gan, Z.Y.6    Kashfi, K.7
  • 19
    • 34547770279 scopus 로고    scopus 로고
    • New uses for old drugs
    • Chong CR and Sullivan DJ, Jr. New uses for old drugs. Nature 448: 645-646, 2007.
    • (2007) Nature , vol.448 , pp. 645-646
    • Chong, C.R.1    Sullivan, D.J.2
  • 20
    • 84888123233 scopus 로고    scopus 로고
    • Thiosulfate in urine as a facilitator in the diagnosis of prostate cancer for patients with prostate-specific antigen less or equal 10 ng/ml
    • Chwatko G, Forma E, Wilkosz J, Gowacki R, Jóźwiak P, Ró-zański W, Brys̈ M, and Krzes̈lak A. Thiosulfate in urine as a facilitator in the diagnosis of prostate cancer for patients with prostate-specific antigen less or equal 10 ng/mL. Clin Chem Lab Med 51: 1825-1831, 2013.
    • (2013) Clin Chem Lab Med , vol.51 , pp. 1825-1831
    • Chwatko, G.1    Forma, E.2    Wilkosz, J.3    Gowacki, R.4    Jóźwiak, P.5    Ró-Zański, W.6    Brys̈, M.7    Krzes̈lak, A.8
  • 23
    • 79955759406 scopus 로고    scopus 로고
    • Therapeutic targeting of cancer cell metabolism
    • Dang CV, Hamaker M, Sun P, Le A, and Gao P. Therapeutic targeting of cancer cell metabolism. J Mol Med (Berl) 89: 205-212, 2011.
    • (2011) J Mol Med (Berl , vol.89 , pp. 205-212
    • Dang, C.V.1    Hamaker, M.2    Sun Le P, A.3    Gao, P.4
  • 25
    • 20444445722 scopus 로고    scopus 로고
    • MTHFR and risk of venous thrombosis a meta-analysis of published epidemiological studies
    • Den Heijer M, Lewington S, and Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost 3: 292-299, 2005.
    • (2005) J Thromb Haemost , vol.3 , pp. 292-299
    • Den Heijer, M.1    Lewington, S.2    Clarke, R.3
  • 26
    • 0037927972 scopus 로고    scopus 로고
    • Hydrogen sulfide induces serum-independent cell cycle entry in nontransformed rat intestinal epithelial cells
    • Deplancke B and Gaskins HR. Hydrogen sulfide induces serum-independent cell cycle entry in nontransformed rat intestinal epithelial cells. FASEB J 17: 1310-1312, 2003.
    • (2003) FASEB J , vol.17 , pp. 1310-1312
    • Deplancke, B.1    Gaskins, H.R.2
  • 28
    • 0030888183 scopus 로고    scopus 로고
    • Homocyst(e)ine: An important risk factor for atherosclerotic vascular disease
    • Duell PB and Malinow MR. Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease. Curr Opin Lipidol 8: 28-34, 1997.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 28-34
    • Duell, P.B.1    Malinow, M.R.2
  • 29
    • 84885071800 scopus 로고    scopus 로고
    • Structural basis of regulation and oligomerization of human cystathionine b-synthase, the central enzyme of transsulfuration
    • Ereño-Orbea J, Majtan T, Oyenarte I, Kraus JP, and Martńez-Cruz LA. Structural basis of regulation and oligomerization of human cystathionine b-synthase, the central enzyme of transsulfuration. Proc Natl Acad Sci U S A 110: E3790-E3799, 2013.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E3790-E3799
    • Ereño-Orbea, J.1    Majtan, T.2    Oyenarte, I.3    Kraus, J.P.4    Martńez-Cruz, L.A.5
  • 30
    • 33745920516 scopus 로고    scopus 로고
    • The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver
    • Fiorucci S, Distrutti E, Cirino G, and Wallace JL. The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver. Gastroenterology 131: 259-271, 2006.
    • (2006) Gastroenterology , vol.131 , pp. 259-271
    • Fiorucci, S.1    Distrutti, E.2    Cirino, G.3    Wallace, J.L.4
  • 31
    • 84857042660 scopus 로고    scopus 로고
    • Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo
    • Frantzias J, Logan JG, Mollat P, Sparatore A, Del Soldato P, Ralston SH, and Idris AI. Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo. Br J Pharmacol 165: 1914-1925, 2012.
    • (2012) Br J Pharmacol , vol.165 , pp. 1914-1925
    • Frantzias, J.1    Logan, J.G.2    Mollat, P.3    Sparatore, A.4    Del Soldato, P.5    Ralston, S.H.6    Idris, A.I.7
  • 32
    • 84857409875 scopus 로고    scopus 로고
    • Hydrogen sulfide (h2s) metabolism in mitochondria and its regulatory role in energy production
    • Fu M, Zhang W, Wu L, Yang G, Li H, and Wang R. Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production. Proc Natl Acad Sci U S A 109: 2943-2948, 2012.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 2943-2948
    • Fu, M.1    Zhang, W.2    Wu, L.3    Yang, G.4    Li, H.5    Wang, R.6
  • 33
    • 0037069752 scopus 로고    scopus 로고
    • Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors nf-ya isoforms and sp1
    • Ge Y, Jensen TL, Matherly LH, and Taub JW. Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1. Biochim Biophys Acta 1579: 73-80, 2002.
    • (2002) Biochim Biophys Acta , vol.1579 , pp. 73-80
    • Ge, Y.1    Jensen, T.L.2    Matherly, L.H.3    Taub, J.W.4
  • 34
    • 0014344268 scopus 로고
    • Cystathioninuria in patients with neuroblastoma or ganglioneuroblastoma its correlation to vanilmandelic acid excretion and its value in diagnosis and therapy
    • Geiser CF and Efron ML. Cystathioninuria in patients with neuroblastoma or ganglioneuroblastoma. Its correlation to vanilmandelic acid excretion and its value in diagnosis and therapy. Cancer 22: 856-860, 1968.
    • (1968) Cancer , vol.22 , pp. 856-860
    • Geiser, C.F.1    Efron, M.L.2
  • 35
    • 0018904834 scopus 로고
    • Cystathioninuria and its origin in children with hepatoblastoma
    • Geiser CF and Shih VE. Cystathioninuria and its origin in children with hepatoblastoma. J Pediatr 96: 72-75, 1980.
    • (1980) J Pediatr , vol.96 , pp. 72-75
    • Geiser, C.F.1    Shih, V.E.2
  • 36
    • 50549199341 scopus 로고
    • Cystathioninuria and vanil-lactic-aciduria in neuroblastoma and argentaffinoma
    • Gjessing LR. Cystathioninuria and vanil-lactic-aciduria in neuroblastoma and argentaffinoma. Lancet 2: 1281-1282, 1963.
    • (1963) Lancet , vol.2 , pp. 1281-1282
    • Gjessing, L.R.1
  • 38
    • 0017720320 scopus 로고
    • Magnitude of malateaspartate reduced nicotinamide adenine dinucleotide shuttle activity in intact respiring tumor cells
    • Greenhouse WV and Lehninger AL. Magnitude of malateaspartate reduced nicotinamide adenine dinucleotide shuttle activity in intact respiring tumor cells. Cancer Res 37: 4173-4181, 1977.
    • (1977) Cancer Res , vol.37 , pp. 4173-4181
    • Greenhouse, W.V.1    Lehninger, A.L.2
  • 40
    • 84863024767 scopus 로고    scopus 로고
    • Characterization of hydrogen sulfide and its synthases, cystathionine b-synthase and cystathionine c-lyase, in human prostatic tissue and cells
    • Guo H, Gai JW, Wang Y, Jin HF, Du JB, and Jin J. Characterization of hydrogen sulfide and its synthases, cystathionine b-synthase and cystathionine c-lyase, in human prostatic tissue and cells. Urology 79: 483, 2012.
    • (2012) Urology , vol.79 , pp. 483
    • Guo, H.1    Gai, J.W.2    Wang, Y.3    Jin, H.F.4    Du, J.B.5    Jin, J.6
  • 42
    • 84880506271 scopus 로고    scopus 로고
    • Correction of cystathionine b-synthase deficiency in mice by treatment with proteasome inhibitors
    • Gupta S, Wang L, Anderl J, Slifker MJ, Kirk C, and Kruger WD. Correction of cystathionine b-synthase deficiency in mice by treatment with proteasome inhibitors. Hum Mutat 34: 1085-1093, 2013.
    • (2013) Hum Mutat , vol.34 , pp. 1085-1093
    • Gupta, S.1    Wang, L.2    Anderl, J.3    Slifker, M.J.4    Kirk, C.5    Kruger, W.D.6
  • 47
    • 84883063361 scopus 로고    scopus 로고
    • Cancer odor in the blood of ovarian cancer patients: A retrospective study of detection by dogs during treatment, 3 and 6 months afterward
    • Horvath G, Andersson H, and Nemes S. Cancer odor in the blood of ovarian cancer patients: a retrospective study of detection by dogs during treatment, 3 and 6 months afterward. BMC Cancer 13: 396, 2013.
    • (2013) BMC Cancer , vol.13 , pp. 396
    • Horvath, G.1    Andersson, H.2    Nemes, S.3
  • 48
    • 84875472117 scopus 로고    scopus 로고
    • Selected ion flow tube mass spectrometry analysis of volatile metabolites in urine headspace for the profiling of gastro-esophageal cancer
    • Huang J, Kumar S, Abbassi-Ghadi N, Spane?l P, Smith D, and Hanna GB. Selected ion flow tube mass spectrometry analysis of volatile metabolites in urine headspace for the profiling of gastro-esophageal cancer. Anal Chem 85: 3409-3416, 2013.
    • (2013) Anal Chem , vol.85 , pp. 3409-3416
    • Huang, J.1    Kumar, S.2    Abbassi-Ghadi, N.3    Spanel, P.4    Smith, D.5    Hanna, G.B.6
  • 49
    • 77955485967 scopus 로고    scopus 로고
    • Hydrogen sulfide, a gaseous transmitter, stimulates proliferation of interstitial cells of cajal via phosphorylation of akt protein kinase
    • Huang Y, Li F, Tong W, Zhang A, He Y, Fu T, and Liu B. Hydrogen sulfide, a gaseous transmitter, stimulates proliferation of interstitial cells of Cajal via phosphorylation of AKT protein kinase. Tohoku J Exp Med 221: 125-132, 2010.
    • (2010) Tohoku J Exp Med , vol.221 , pp. 125-132
    • Huang, Y.1    Li, F.2    Tong, W.3    Zhang, A.4    He, Y.5    Fu, T.6    Liu, B.7
  • 50
    • 77956194462 scopus 로고    scopus 로고
    • Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury
    • Ishii I, Akahoshi N, Yamada H, Nakano S, Izumi T, and Suematsu M. Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury J Biol Chem 285: 26358-26368, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 26358-26368
    • Ishii, I.1    Akahoshi, N.2    Yamada, H.3    Nakano, S.4    Izumi, T.5    Suematsu, M.6
  • 51
    • 27744467308 scopus 로고    scopus 로고
    • Molecular targeting by homocysteine: A mechanism for vascular pathogenesis
    • Jacobsen DW, Catanescu O, Dibello PM, and Barbato JC. Molecular targeting by homocysteine: a mechanism for vascular pathogenesis. Clin Chem Lab Med 43: 1076-1083, 2005.
    • (2005) Clin Chem Lab Med , vol.43 , pp. 1076-1083
    • Jacobsen, D.W.1    Catanescu, O.2    Dibello, P.M.3    Barbato, J.C.4
  • 52
    • 17644384824 scopus 로고    scopus 로고
    • The role of cystathionine betasynthase in homocysteine metabolism
    • Jhee KH and Kruger WD. The role of cystathionine betasynthase in homocysteine metabolism. Antioxid Redox Signal 7: 813-822, 2005.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 813-822
    • Jhee, K.H.1    Kruger, W.D.2
  • 55
    • 84893478853 scopus 로고    scopus 로고
    • Enzymology of h2s biogenesis, decay and signaling
    • Kabil O and Banerjee R. Enzymology of H2S biogenesis, decay and signaling. Antioxid Redox Signal 20: 770-782, 2014.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 770-782
    • Kabil, O.1    Banerjee, R.2
  • 56
    • 33751027683 scopus 로고    scopus 로고
    • Human cystathionine beta-synthase is a target for sumoylation
    • Kabil O, Zhou Y, and Banerjee R. Human cystathionine beta-synthase is a target for sumoylation. Biochemistry 45: 13528-13536, 2006.
    • (2006) Biochemistry , vol.45 , pp. 13528-13536
    • Kabil, O.1    Zhou, Y.2    Banerjee, R.3
  • 58
    • 84893465586 scopus 로고    scopus 로고
    • Anti-cancer activity of new designer hydrogen sulfide-donating hybrids
    • Kashfi K. Anti-cancer activity of new designer hydrogen sulfide-donating hybrids. Antioxid Redox Signal 20: 831-846, 2014.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 831-846
    • Kashfi, K.1
  • 59
    • 0032528375 scopus 로고    scopus 로고
    • Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: Structural and functional consequences
    • Kery V, Poneleit L, and Kraus JP. Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: structural and functional consequences. Arch Biochem Biophys 355: 222-232, 1998.
    • (1998) Arch Biochem Biophys , vol.355 , pp. 222-232
    • Kery, V.1    Poneleit, L.2    Kraus, J.P.3
  • 60
    • 78651457395 scopus 로고    scopus 로고
    • Hydrogen sulfide: Its production, release and functions
    • Kimura H. Hydrogen sulfide: its production, release and functions. Amino Acids 41: 113-121, 2011.
    • (2011) Amino Acids , vol.41 , pp. 113-121
    • Kimura, H.1
  • 61
    • 84907598996 scopus 로고    scopus 로고
    • The physiological role of hydrogen sulfide and beyond
    • [Epub ahead of print];
    • Kimura H. The physiological role of hydrogen sulfide and beyond. Nitric Oxide 2014 [Epub ahead of print]; DOI: 10.1016/j.niox.2014.01.002.
    • (2014) Nitric Oxide
    • Kimura, H.1
  • 62
    • 84878764595 scopus 로고    scopus 로고
    • Polysulfides are possible h2s-derived signaling molecules in rat brain
    • Kimura Y, Mikami Y, Osumi K, Tsugane M, Oka J, and Kimura H. Polysulfides are possible H2S-derived signaling molecules in rat brain. FASEB J 27: 2451-2457, 2013.
    • (2013) FASEB J , vol.27 , pp. 2451-2457
    • Kimura, Y.1    Mikami, Y.2    Osumi, K.3    Tsugane, M.4    Oka, J.5    Kimura, H.6
  • 64
    • 84886774071 scopus 로고    scopus 로고
    • Synthesis and biological activity of nosh-naproxen (avt-219) and nosh-sulindac (avt-18a) as potent anti-inflammatory agents with chemotherapeutic potential
    • Kodela R, Chattopadhyay M, and Kashfi K. Synthesis and biological activity of NOSH-naproxen (AVT-219) and NOSH-sulindac (AVT-18A) as potent anti-inflammatory agents with chemotherapeutic potential. Med Chem Comm 4: 1039, 2013.
    • (2013) Med Chem Comm , vol.4 , pp. 1039
    • Kodela, R.1    Chattopadhyay, M.2    Kashfi, K.3
  • 65
    • 84886243717 scopus 로고    scopus 로고
    • Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through nrf2 signaling in neuroblastoma cells
    • Koike S, Ogasawara Y, Shibuya N, Kimura H, and Ishii K. Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells. FEBS Lett 587: 3548-3555, 2013.
    • (2013) FEBS Lett , vol.587 , pp. 3548-3555
    • Koike, S.1    Ogasawara, Y.2    Shibuya, N.3    Kimura, H.4    Ishii, K.5
  • 66
    • 83655165310 scopus 로고    scopus 로고
    • H2sinduced sulfhydration of the phosphatase ptp1b and its role in the endoplasmic reticulum stress response
    • Krishnan N, Fu C, Pappin DJ, and Tonks NK. H2SInduced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal 4: ra86, 2011.
    • (2011) Sci Signal , vol.4 , pp. ra86
    • Krishnan, N.1    Fu, C.2    Pappin, D.J.3    Tonks, N.K.4
  • 67
    • 84868534671 scopus 로고    scopus 로고
    • Selected ion flow tube-ms analysis of headspace vapor from gastric content for the diagnosis of gastroesophageal cancer
    • Kumar S, Huang J, Cushnir JR, S ? pane?l P, Smith D, and Hanna GB. Selected ion flow tube-MS analysis of headspace vapor from gastric content for the diagnosis of gastroesophageal cancer. Anal Chem 84: 9550-9557, 2012.
    • (2012) Anal Chem , vol.84 , pp. 9550-9557
    • Kumar, S.1    Huang, J.2    Cushnir, J.R.3    Spanel, P.4    Smith, D.5    Hanna, G.B.6
  • 68
    • 77955672171 scopus 로고    scopus 로고
    • Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes
    • Lagoutte E, Mimoun S, Andriamihaja M, Chaumontet C, Blachier F, and Bouillaud F. Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes. Biochim Biophys Acta 1797: 1500-1511, 2010.
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 1500-1511
    • Lagoutte, E.1    Mimoun, S.2    Andriamihaja, M.3    Chaumontet, C.4    Blachier, F.5    Bouillaud, F.6
  • 69
    • 79959312178 scopus 로고    scopus 로고
    • The slow-releasing hydrogen sulfide donor, gyy4137, exhibits novel anti-cancer effects in vitro and in vivo
    • Lee ZW, Zhou J, Chen CS, Zhao Y, Tan CH, Li L, Moore PK, and Deng LW. The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One 6:-21077, 2011.
    • (2011) PLoS One , vol.6 , pp. 21077
    • Lee, Z.W.1    Zhou, J.2    Chen, C.S.3    Zhao, Y.4    Tan, C.H.5    Li, L.6    Moore, P.K.7    Deng, L.W.8
  • 72
    • 84876908221 scopus 로고    scopus 로고
    • Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging h2o2-dependent h2s production
    • Lin VS, Lippert AR, and Chang CJ. Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production. Proc Natl Acad Sci U S A 110: 7131-7135, 2013.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 7131-7135
    • Lin, V.S.1    Lippert, A.R.2    Chang, C.J.3
  • 73
    • 79959595792 scopus 로고    scopus 로고
    • H2s donor s-propargyl-cysteine, increases cse in sgc-7901 and cancer-induced mice: Evidence for a novel anti-cancer effect of endogenous h2s?
    • Ma K, Liu Y, Zhu Q, Liu CH, Duan JL, Tan BK, and Zhu YZ. H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti-cancer effect of endogenous H2S? PLoS One 6:-20525, 2011.
    • (2011) PLoS One , vol.6 , pp. 20525
    • Ma, K.1    Liu, Y.2    Zhu, Q.3    Liu, C.H.4    Duan, J.L.5    Tan, B.K.6    Zhu, Y.Z.7
  • 74
    • 1542335734 scopus 로고    scopus 로고
    • The dominant role of sp1 in regulating the cystathionine beta-synthase-1a and-1b promoters facilitates potential tissue-specific regulation by kruppel-like factors
    • Maclean KN, Kraus E, and Kraus JP. The dominant role of Sp1 in regulating the cystathionine beta-synthase-1a and-1b promoters facilitates potential tissue-specific regulation by Kruppel-like factors. J Biol Chem 279: 8558-8566, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 8558-8566
    • Maclean, K.N.1    Kraus, E.2    Kraus, J.P.3
  • 76
    • 81155132233 scopus 로고    scopus 로고
    • Hydrogen sulfide and l-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (pip3) and glucose utilization by inhibiting phosphatase and tensin homolog (pten) protein and activating phosphoinositide 3-kinase (pi3k)/serine/threonine protein kinase (akt)/protein kinase cf/k (pkcf/k) in 3t3l1 adipocytes
    • Manna P and Jain SK. Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/protein kinase Cf/k (PKCf/k) in 3T3l1 adipocytes. J Biol Chem 286: 39848-39859, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 39848-39859
    • Manna, P.1    Jain, S.K.2
  • 78
    • 3142749051 scopus 로고    scopus 로고
    • Cystathionine beta-synthase: Structure, function, regulation, and location of homocystinuria-causing mutations
    • Miles EW and Kraus JP. Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations. J Biol Chem 279: 29871-29874, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 29871-29874
    • Miles, E.W.1    Kraus, J.P.2
  • 80
    • 84907302687 scopus 로고    scopus 로고
    • Effect of s-adenosyl-l-methionine (sam), an allosteric activator of cystathionine-b-synthase (cbs) on colorectal cancer cell proliferation and bioenergetics in vitro
    • [Epub ahead of print];
    • Módis K, Coletta C, Asimakopoulou A, Szczesny B, Chao C, Papapetropoulos A, Hellmich MR, and Szabo C. Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-b-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro. Nitric Oxide 2014 [Epub ahead of print]; DOI: 10.1016/j.niox.2014.03.001.
    • (2014) Nitric Oxide
    • Módis, K.1    Coletta, C.2    Asimakopoulou, A.3    Szczesny, B.4    Chao, C.5    Papapetropoulos, A.6    Hellmich, M.R.7    Szabo, C.8
  • 81
    • 84873467050 scopus 로고    scopus 로고
    • Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics
    • Módis K, Coletta C, Erdélyi K, Papapetropoulos A, and Szabo C. Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics. FASEB J 27: 601-611, 2013.
    • (2013) FASEB J , vol.27 , pp. 601-611
    • Módis, K.1    Coletta, C.2    Erdélyi, K.3    Papapetropoulos, A.4    Szabo, C.5
  • 82
    • 84886728728 scopus 로고    scopus 로고
    • Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2a, elevation of camp and activation of protein kinase a
    • Módis K, Panopoulos P, Coletta C, Papapetropoulos A, and Szabo C. Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A. Biochem Pharmacol 86: 1311-1319, 2013.
    • (2013) Biochem Pharmacol , vol.86 , pp. 1311-1319
    • Módis, K.1    Panopoulos, P.2    Coletta, C.3    Papapetropoulos, A.4    Szabo, C.5
  • 84
    • 84890858026 scopus 로고    scopus 로고
    • Differential susceptibility to hydrogen sulfide-induced apoptosis between phlda1-overexpressing oral cancer cell lines and oral keratinocytes: Role of phlda1 as an apoptosis suppressor
    • Murata T, Sato T, Kamoda T, Moriyama H, Kumazawa Y, and Hanada N. Differential susceptibility to hydrogen sulfide-induced apoptosis between PHLDA1-overexpressing oral cancer cell lines and oral keratinocytes: Role of PHLDA1 as an apoptosis suppressor. Exp Cell Res 320: 247-257, 2014.
    • (2014) Exp Cell Res , vol.320 , pp. 247-257
    • Murata, T.1    Sato, T.2    Kamoda, T.3    Moriyama, H.4    Kumazawa, Y.5    Hanada, N.6
  • 86
    • 84877678495 scopus 로고    scopus 로고
    • Selective homocysteine lowering gene transfer improves infarct healing, attenuates remodelling, and enhances diastolic function after myocardial infarction in mice
    • Muthuramu I, Jacobs F, Singh N, Gordts SC, and De Geest B. Selective homocysteine lowering gene transfer improves infarct healing, attenuates remodelling, and enhances diastolic function after myocardial infarction in mice. PLoS One 8:-63710, 2013.
    • (2013) PLoS One , vol.8 , pp. 63710
    • Muthuramu, I.1    Jacobs, F.2    Singh, N.3    Gordts, S.C.4    De Geest, B.5
  • 87
    • 84907130469 scopus 로고
    • A technique for c-banding chromosomes with pinacyanol chloride
    • Narayan RK. A technique for C-banding chromosomes with pinacyanol chloride. Stain Technol 55: 9-11, 1980.
    • (1980) Stain Technol , vol.55 , pp. 9-11
    • Narayan, R.K.1
  • 88
    • 0016709873 scopus 로고
    • Inhibition of cytochrome c oxidase by sulphide
    • Nicholls P. Inhibition of cytochrome c oxidase by sulphide. Biochem Soc Trans 3: 316-319, 1975.
    • (1975) Biochem Soc Trans , vol.3 , pp. 316-319
    • Nicholls, P.1
  • 89
    • 84891674401 scopus 로고    scopus 로고
    • Effect of folic acid, vitamin b6 and vitamin b12 supplementation on mortality and cardiovascular complication among patients with chronic kidney disease: An evidence-based case report
    • Nursalim A, Siregar P, and Widyahening IS. Effect of folic acid, vitamin B6 and vitamin B12 supplementation on mortality and cardiovascular complication among patients with chronic kidney disease: an evidence-based case report. Acta Med Indones 45: 150-156, 2013.
    • (2013) Acta Med Indones , vol.45 , pp. 150-156
    • Nursalim, A.1    Siregar, P.2    Widyahening, I.S.3
  • 90
    • 67649265267 scopus 로고    scopus 로고
    • Is hydrogen sulfide a circulating "gasotransmitter" in vertebrate blood?
    • Olson KR. Is hydrogen sulfide a circulating "gasotransmitter" in vertebrate blood? Biochim Biophys Acta 1787: 856-863, 2009.
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 856-863
    • Olson, K.R.1
  • 92
    • 0018138765 scopus 로고
    • Biochemical effects in man and rat of three drugs which can increase brain gaba content
    • Perry TL and Hansen S. Biochemical effects in man and rat of three drugs which can increase brain GABA content. J Neurochem 30: 679-684, 1978.
    • (1978) J Neurochem , vol.30 , pp. 679-684
    • Perry, T.L.1    Hansen, S.2
  • 97
    • 84871634253 scopus 로고    scopus 로고
    • Promoter demethylation of cystathionine-b-synthetase gene contributes to inflammatory pain in rats
    • Qi F, Zhou Y, Xiao Y, Tao J, Gu J, Jiang X, and Xu GY. Promoter demethylation of cystathionine-b-synthetase gene contributes to inflammatory pain in rats. Pain 154: 34-45, 2013.
    • (2013) Pain , vol.154 , pp. 34-45
    • Qi, F.1    Zhou, Y.2    Xiao, Y.3    Tao, J.4    Gu, J.5    Jiang, X.6    Xu, G.Y.7
  • 98
    • 84857944770 scopus 로고    scopus 로고
    • Hydrogen sulfide mitigates cardiac remodeling during myocardial infarction via improvement of angiogenesis
    • Qipshidze N, Metreveli N, Mishra PK, Lominadze D, and Tyagi SC. Hydrogen sulfide mitigates cardiac remodeling during myocardial infarction via improvement of angiogenesis. Int J Biol Sci 8: 430-441, 2012.
    • (2012) Int J Biol Sci , vol.8 , pp. 430-441
    • Qipshidze, N.1    Metreveli, N.2    Mishra, P.K.3    Lominadze, D.4    Tyagi, S.C.5
  • 99
    • 33745778247 scopus 로고    scopus 로고
    • Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation
    • Ramasamy S, Singh S, Taniere P, Langman MJ, and Eggo MC. Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation. Am J Physiol Gastrointest Liver Physiol 291: G288-G296, 2006.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291 , pp. G288-G296
    • Ramasamy, S.1    Singh, S.2    Taniere, P.3    Langman, M.J.4    Eggo, M.C.5
  • 102
    • 0242611913 scopus 로고    scopus 로고
    • Pinacyanol as effective probe of fibrillar beta-amyloid peptide: Comparative study with congo red
    • Sabaté R and Estelrich J. Pinacyanol as effective probe of fibrillar beta-amyloid peptide: comparative study with Congo Red. Biopolymers 72: 455-463, 2003.
    • (2003) Biopolymers , vol.72 , pp. 455-463
    • Sabaté, R.1    Estelrich, J.2
  • 103
    • 65549123260 scopus 로고    scopus 로고
    • Mitochondrial uncoupling and the warburg effect: Molecular basis for the reprogramming of cancer cell metabolism
    • Samudio I, Fiegl M, and Andreeff M. Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism. Cancer Res 69: 2163-2166, 2009.
    • (2009) Cancer Res , vol.69 , pp. 2163-2166
    • Samudio, I.1    Fiegl, M.2    Andreeff, M.3
  • 106
    • 84921908879 scopus 로고    scopus 로고
    • Development of a new assay and inhibitors for human cystathionine beta-synthase
    • PhD dissertation, University of Nebraska
    • Shen W. Development of a new assay and inhibitors for human cystathionine beta-synthase. Asymmetric catalyst development guided by in situ enzymatic screening. PhD dissertation, University of Nebraska, 2007.
    • (2007) Asymmetric Catalyst Development Guided by in Situ Enzymatic Screening.
    • Shen, W.1
  • 107
    • 76749160942 scopus 로고    scopus 로고
    • Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce hsp70
    • Singh LR, Gupta S, Honig NH, Kraus JP, and Kruger WD. Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70. PLoS Genet 6:-1000807, 2010.
    • (2010) PLoS Genet , vol.6 , pp. 1000807
    • Singh, L.R.1    Gupta, S.2    Honig, N.H.3    Kraus, J.P.4    Kruger, W.D.5
  • 108
    • 80051929163 scopus 로고    scopus 로고
    • Plp-dependent h2s biogenesis
    • Singh S and Banerjee R. PLP-dependent H2S biogenesis. Biochim Biophys Acta 1814: 1518-1527, 2011.
    • (2011) Biochim Biophys Acta , vol.1814 , pp. 1518-1527
    • Singh, S.1    Banerjee, R.2
  • 109
    • 69249100078 scopus 로고    scopus 로고
    • Relative contributions of cystathionine beta-synthase and gamma-cystathionase to h2s biogenesis via alternative transsulfuration reactions
    • Singh S, Padovani D, Leslie RA, Chiku T, and Banerjee R. Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative transsulfuration reactions. J Biol Chem 284: 22457-22466, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 22457-22466
    • Singh, S.1    Padovani, D.2    Leslie, R.A.3    Chiku, T.4    Banerjee, R.5
  • 113
    • 84873832650 scopus 로고    scopus 로고
    • Comparative study of enzyme activity and heme reactivity in drosophila melanogaster and homo sapiens cystathionine b-synthases
    • Su Y, Majtan T, Freeman KM, Linck R, Ponter S, Kraus JP, and Burstyn JN. Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine b-synthases. Biochemistry 52: 741-751, 2013.
    • (2013) Biochemistry , vol.52 , pp. 741-751
    • Su, Y.1    Majtan, T.2    Freeman, K.M.3    Linck, R.4    Ponter, S.5    Kraus, J.P.6    Burstyn, J.N.7
  • 115
    • 78649439251 scopus 로고    scopus 로고
    • Gaseotransmitters: New frontiers for translational science
    • Szabo C. Gaseotransmitters: new frontiers for translational science. Sci Transl Med 2: 59ps54, 2010.
    • (2010) Sci Transl Med , vol.2 , pp. 59ps54
    • Szabo, C.1
  • 116
    • 35748959038 scopus 로고    scopus 로고
    • Hydrogen sulphide and its therapeutic potential
    • Szabo C. Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6: 917-935, 2007.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 917-935
    • Szabo, C.1
  • 117
    • 79952283375 scopus 로고    scopus 로고
    • Medicinal chemistry and therapeutic applications of the gasotransmitters nitric oxide, carbon monoxide and hydrogen sulfide
    • Szabo C. Medicinal chemistry and therapeutic applications of the gasotransmitters nitric oxide, carbon monoxide and hydrogen sulfide. Burgers Med Chem 5: 265-367, 2010.
    • (2010) Burgers Med Chem , vol.5 , pp. 265-367
    • Szabo, C.1
  • 118
    • 84880690612 scopus 로고    scopus 로고
    • Tumor-derived hydrogen sulfide, produced by cystathionine-b-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
    • Szabo C, Coletta C, Chao C, Módis K, Szczesny B, Papapetropoulos A, and Hellmich MR. Tumor-derived hydrogen sulfide, produced by cystathionine-b-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer. Proc Natl Acad Sci U S A 110: 12474-12479, 2013.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 12474-12479
    • Szabo, C.1    Coletta, C.2    Chao, C.3    Módis, K.4    Szczesny, B.5    Papapetropoulos, A.6    Hellmich, M.R.7
  • 119
    • 84884947271 scopus 로고    scopus 로고
    • Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation
    • Szabo C and Hellmich MR. Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation. Cell Cycle 12: 2915-2916, 2013.
    • (2013) Cell Cycle , vol.12 , pp. 2915-2916
    • Szabo, C.1    Hellmich, M.R.2
  • 120
    • 80052020182 scopus 로고    scopus 로고
    • Hydrogen sulphide and angiogenesis: Mechanisms and applications
    • Szabo C and Papapetropoulos A. Hydrogen sulphide and angiogenesis: mechanisms and applications. Br J Pharmacol 164: 853-865, 2011.
    • (2011) Br J Pharmacol , vol.164 , pp. 853-865
    • Szabo, C.1    Papapetropoulos, A.2
  • 123
    • 84874575518 scopus 로고    scopus 로고
    • Vegfr2 functions as an h2s-targeting receptor protein kinase with its novel cys1045-cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells
    • Tao BB, Liu SY, Zhang CC, Fu W, Cai WJ, Wang Y, Shen Q, Wang MJ, Chen Y, Zhang LJ, Zhu YZ, and Zhu YC. VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells. Antioxid Redox Signal 19: 448-464, 2013.
    • (2013) Antioxid Redox Signal , vol.19 , pp. 448-464
    • Tao, B.B.1    Liu, S.Y.2    Zhang, C.C.3    Fu, W.4    Cai, W.J.5    Wang, Y.6    Shen, Q.7    Wang, M.J.8    Chen, Y.9    Zhang, L.J.10    Zhu, Y.Z.11    Zhu, Y.C.12
  • 124
    • 84881101982 scopus 로고    scopus 로고
    • Oxygen-sensitive mitochondrial accumulation of cystathionine b-synthase mediated by lon protease
    • Teng H, Wu B, Zhao K, Yang G, Wu L, and Wang R. Oxygen-sensitive mitochondrial accumulation of cystathionine b-synthase mediated by Lon protease. Proc Natl Acad Sci U S A 110: 12679-12684, 2013.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 12679-12684
    • Teng, H.1    Wu, B.2    Zhao, K.3    Yang, G.4    Wu, L.5    Wang, R.6
  • 126
    • 84876503415 scopus 로고    scopus 로고
    • Identification of cystathionine b-synthase inhibitors using a hydrogen sulfide selective probe
    • Thorson MK, Majtan T, Kraus JP, and Barrios AM. Identification of cystathionine b-synthase inhibitors using a hydrogen sulfide selective probe. Angew Chem Int Ed Engl 52: 4641-4644, 2013.
    • (2013) Angew Chem Int Ed Engl , vol.52 , pp. 4641-4644
    • Thorson, M.K.1    Majtan, T.2    Kraus, J.P.3    Barrios, A.M.4
  • 128
    • 34548431842 scopus 로고    scopus 로고
    • Testosterone regulation of renal cystathionine beta-synthase: Implications for sex-dependent differences in plasma homocysteine levels
    • Vitvitsky V, Prudova A, Stabler S, Dayal S, Lentz SR, and Banerjee R. Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels. Am J Physiol Renal Physiol 293: F594-F600, 2007.
    • (2007) Am J Physiol Renal Physiol , vol.293 , pp. F594-F600
    • Vitvitsky, V.1    Prudova, A.2    Stabler, S.3    Dayal, S.4    Lentz, S.R.5    Banerjee, R.6
  • 129
    • 0014356028 scopus 로고
    • Cystathioninuria in hepatoblastoma
    • Vou͗e PA, Jr., and Wadman SK. Cystathioninuria in hepatoblastoma. Clin Chim Acta 22: 373-378, 1968.
    • (1968) Clin Chim Acta , vol.22 , pp. 373-378
    • Vou͗e, P.A.1    Wadman, S.K.2
  • 130
    • 2642513835 scopus 로고    scopus 로고
    • Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice
    • Wang L, Jhee KH, Hua X, DiBello PM, Jacobsen DW, and Kruger WD. Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circ Res 94: 1318-1324, 2004.
    • (2004) Circ Res , vol.94 , pp. 1318-1324
    • Wang, L.1    Jhee, K.H.2    Hua, X.3    Dibello, P.M.4    Jacobsen, D.W.5    Kruger, W.D.6
  • 131
    • 77950796610 scopus 로고    scopus 로고
    • The hydrogen sulfide donor nahs promotes angiogenesis in a rat model of hind limb ischemia
    • Wang MJ, Cai WJ, Li N, Ding YJ, Chen Y, and Zhu YC. The hydrogen sulfide donor NaHS promotes angiogenesis in a rat model of hind limb ischemia. Antioxid Redox Signal 12: 1065-1077, 2010.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1065-1077
    • Wang, M.J.1    Cai, W.J.2    Li, N.3    Ding, Y.J.4    Chen, Y.5    Zhu, Y.C.6
  • 132
    • 77953858725 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis: Role of hydrogen sulphide
    • Wang MJ, Cai WJ, and Zhu YC. Mechanisms of angiogenesis: role of hydrogen sulphide. Clin Exp Pharmacol Physiol 37: 764-771, 2010.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 764-771
    • Wang, M.J.1    Cai, W.J.2    Zhu, Y.C.3
  • 133
    • 84860117196 scopus 로고    scopus 로고
    • Physiological implications of hydrogen sulfide: A whiff exploration that blossomed
    • Wang R. Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Physiol Rev 92: 791-896, 2012.
    • (2012) Physiol Rev , vol.92 , pp. 791-896
    • Wang, R.1
  • 135
    • 84871604292 scopus 로고    scopus 로고
    • Targeting cancer cell mitochondria as a therapeutic approach
    • Wen S, Zhu D, and Huang P. Targeting cancer cell mitochondria as a therapeutic approach. Future Med Chem 5: 53-67, 2013.
    • (2013) Future Med Chem , vol.5 , pp. 53-67
    • Wen, S.1    Zhu, D.2    Huang, P.3
  • 136
    • 84873487192 scopus 로고    scopus 로고
    • Hydrogen sulfide protects huvecs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress
    • Wen YD, Wang H, Kho SH, Rinkiko S, Sheng X, Shen HM, and Zhu YZ. Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress. PLoS One 8:-53147, 2013.
    • (2013) PLoS One , vol.8 , pp. 53147
    • Wen, Y.D.1    Wang, H.2    Kho, S.H.3    Rinkiko, S.4    Sheng, X.5    Shen, H.M.6    Zhu, Y.Z.7
  • 137
    • 77950843215 scopus 로고    scopus 로고
    • The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators inmacrophages
    • Whiteman M, Li L, Rose P, Tan CH, Parkinson DB, and Moore PK. The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators inmacrophages. Antioxid Redox Signal 12: 1147-1154, 2010.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1147-1154
    • Whiteman, M.1    Li, L.2    Rose, P.3    Tan, C.H.4    Parkinson, D.B.5    Moore, P.K.6
  • 138
    • 4744340118 scopus 로고    scopus 로고
    • Olfactory detection of human bladder cancer by dogs: Proof of principle study
    • Willis CM, Church SM, and Guest CM. Olfactory detection of human bladder cancer by dogs: proof of principle study. BMJ 329: 712-714, 2004.
    • (2004) BMJ , vol.329 , pp. 712-714
    • Willis, C.M.1    Church, S.M.2    Guest, C.M.3
  • 140
    • 84861551934 scopus 로고    scopus 로고
    • Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells
    • Wu YC, Wang XJ, Yu L, Chan FK, Cheng AS, Yu J, Sung JJ, Wu WK, and Cho CH. Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells. PLoS One 7:-37572, 2012.
    • (2012) PLoS One , vol.7 , pp. 37572
    • Wu, Y.C.1    Wang, X.J.2    Yu, L.3    Chan, F.K.4    Cheng, A.S.5    Yu, J.6    Sung, J.J.7    Wu, W.K.8    Cho, C.H.9
  • 142
    • 33751031794 scopus 로고    scopus 로고
    • Structural insights into pathogenic mutations in heme-dependent cystathionine-beta-synthase
    • Yamanishi M, Kabil O, Sen S, and Banerjee R. Structural insights into pathogenic mutations in heme-dependent cystathionine-beta-synthase. J Inorg Biochem 100: 1988-1995, 2006.
    • (2006) J Inorg Biochem , vol.100 , pp. 1988-1995
    • Yamanishi, M.1    Kabil, O.2    Sen, S.3    Banerjee, R.4
  • 144
    • 84876135908 scopus 로고    scopus 로고
    • Hydrogen sulfide protects against cellular senescence via s-sulfhydration of keap1 and activation of nrf2
    • Yang G, Zhao K, Ju Y, Mani S, Cao Q, Puukila S, Khaper N, Wu L, and Wang R. Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. Antioxid Redox Signal 18: 1906-1919, 2013.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1906-1919
    • Yang, G.1    Zhao, K.2    Ju, Y.3    Mani, S.4    Cao, Q.5    Puukila, S.6    Khaper, N.7    Wu, L.8    Wang, R.9
  • 145
    • 84859049069 scopus 로고    scopus 로고
    • Sp1 is involved in regulation of cystathionine c-lyase gene expression and biological function by pi3k/akt pathway in human hepatocellular carcinoma cell lines
    • Yin P, Zhao C, Li Z, Mei C, Yao W, Liu Y, Li N, Qi J, Wang L, Shi Y, Qiu S, Fan J, and Zha X. Sp1 is involved in regulation of cystathionine c-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines. Cell Signal 24: 1229-1240, 2012.
    • (2012) Cell Signal , vol.24 , pp. 1229-1240
    • Yin, P.1    Zhao, C.2    Li, Z.3    Mei, C.4    Yao, W.5    Liu, Y.6    Li, N.7    Qi, J.8    Wang, L.9    Shi, Y.10    Qiu, S.11    Fan, J.12    Zha, X.13
  • 146
    • 84862803353 scopus 로고    scopus 로고
    • Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia
    • Yu M, Sturgill-Short G, Ganapathy P, Tawfik A, Peachey NS, and Smith SB. Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia. Exp Eye Res 96: 124-131, 2012.
    • (2012) Exp Eye Res , vol.96 , pp. 124-131
    • Yu, M.1    Sturgill-Short, G.2    Ganapathy, P.3    Tawfik, A.4    Peachey, N.S.5    Smith, S.B.6
  • 147
    • 13944262493 scopus 로고    scopus 로고
    • Expression profiling of homocysteine junction enzymes in the nci60 panel of human cancer cell lines
    • Zhang W, Braun A, Bauman Z, Olteanu H, Madzelan P, and Banerjee R. Expression profiling of homocysteine junction enzymes in the NCI60 panel of human cancer cell lines. Cancer Res 65: 1554-1560, 2005.
    • (2005) Cancer Res , vol.65 , pp. 1554-1560
    • Zhang, W.1    Braun, A.2    Bauman, Z.3    Olteanu, H.4    Madzelan, P.5    Banerjee, R.6
  • 148
    • 84888222924 scopus 로고    scopus 로고
    • High-throughput tandemmicrowell assay identifies inhibitors of the hydrogen sulfide signaling pathway
    • Zhou Y, Yu J, Lei X, Wu J, Niu Q, Zhang Y, Liu H, Christen P, Gehring H, and Wu F. High-throughput tandemmicrowell assay identifies inhibitors of the hydrogen sulfide signaling pathway. Chem Commun (Camb) 49: 11782-11784, 2013.
    • (2013) Chem Commun (Camb , vol.49 , pp. 11782-11784
    • Zhou, Y.1    Yu, J.2    Lei, X.3    Wu, J.4    Niu, Q.5    Zhang, Y.6    Liu, H.7    Christen, P.8    Gehring, H.9    Wu, F.10
  • 149
    • 0038269014 scopus 로고    scopus 로고
    • Tumor necrosis factor-alphainduced targeted proteolysis of cystathionine beta-synthase modulates redox homeostasis
    • Zou C-G and Banerjee R. Tumor necrosis factor-alphainduced targeted proteolysis of cystathionine beta-synthase modulates redox homeostasis. J Biol Chem 278: 16802-16808, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 16802-16808
    • Zou, C.-G.1    Banerjee, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.