A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in blood

British Journal of Pharmacology

Volumn 160, Issue 4, 2010, Pages 941-957

  Wintner, Edward A ^a   Deckwerth, Thomas L ^a   Langston, William ^a   Bengtsson, Asa ^a   Leviten, Dina ^a   Hill, Paul ^a   Insko, Michael A ^a   Dumpit, Ronald ^a   Vandenekart, Emily ^a   Toombs, Christopher F ^a   Szabo, Csaba ^a  

^a MALLINCKRODT PHARMACEUTICALS   (United States)

Author keywords

Amperometric detection; Bimane; Blood; Fluorescence detection; Hydrogen sulphide; Monobromobimane; Pharmacokinetics; Sodium sulphide

Indexed keywords

BROMOBIMANE; HYDROGEN SULFIDE; SODIUM CHLORIDE; SODIUM SULFIDE; SULFIDE DIBIMANE; UNCLASSIFIED DRUG; BICYCLO COMPOUND; FLUORESCENT DYE; FREE RADICAL; SULFIDE; THIOL DERIVATIVE; THIOL REAGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG HALF LIFE; EXTRACTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; NONHUMAN; POTENTIOMETRY; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSOR; SEPARATION TECHNIQUE; ANALYSIS; ANIMAL; BLOOD; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KINETICS; LIMIT OF DETECTION; PROCEDURES; SPECTROFLUOROMETRY; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY;

ANALYTIC SAMPLE PREPARATION METHODS; ANIMALS; BICYCLO COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORESCENT DYES; FREE RADICALS; HUMANS; HYDROGEN SULFIDE; KINETICS; LIMIT OF DETECTION; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFHYDRYL COMPOUNDS; SULFHYDRYL REAGENTS; SULFIDES; TANDEM MASS SPECTROMETRY;

EID: 77952859292     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00704.x     Document Type: Article

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