Cystathionine γ-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury

Journal of Biological Chemistry

Volumn 285, Issue 34, 2010, Pages 26358-26368

  Ishii, Isao ^a,b   Akahoshi, Noriyuki ^a,b,c   Yamada, Hidenori ^a,b   Nakano, Shintaro ^a   Izumi, Takashi ^b   Suematsu, Makoto ^a,c  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Japan Science and Technology Agency   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; CULTURE MEDIUM; ENHANCED GENE EXPRESSION; GLUTATHIONES; HEPATOCYTES; HOMOCYSTEINES; HYPERHOMOCYSTEINEMIA; INTRACELLULAR ACCUMULATION; MYOFIBERS; NEWBORN SCREENING; OXIDATIVE INJURY; PREMATURE INFANTS; SKELETAL MUSCLE; SYNTHASES; SYNTHETASES;

AMINO ACIDS; ELECTRIC CIRCUIT BREAKERS; ENZYMES; GENE EXPRESSION; MAMMALS; NUTRITION; ORGANIC ACIDS;

MUSCLE;

ASPARTATE AMMONIA LIGASE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; GLUTATHIONE; MUSCLE PROTEIN; PROTEIN LC3; PROTEIN P62; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; CYSTATHIONEMIA; CYSTATHIONINURIA; ENZYME DEFICIENCY; FEMALE; GENE EXPRESSION; HYPERHOMOCYSTEINEMIA; HYPERMETHIONINEMIA; LIVER; LIVER CELL; MALE; MOUSE; MYOPATHY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN LOCALIZATION; SENSITIVITY ANALYSIS; SKELETAL MUSCLE;

ANIMALS; CYSTATHIONINE GAMMA-LYASE; CYSTEINE; DISEASE MODELS, ANIMAL; HOMOCYSTINURIA; HYPERHOMOCYSTEINEMIA; MICE; MICE, KNOCKOUT; MUSCULAR DISEASES; OXIDATIVE STRESS; PROTECTIVE AGENTS;

ANIMALIA; MAMMALIA; MUS;

EID: 77956194462     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.147439     Document Type: Article

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