Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A

Biochemical Pharmacology

Volumn 86, Issue 9, 2013, Pages 1311-1319

  Módis, Katalin ^a   Panopoulos, Panagiotis ^b   Coletta, Ciro ^a   Papapetropoulos, Andreas ^a,b   Szabo, Csaba ^a  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

cAMP; Isolated mitochondria; Phosphodiesterase

Indexed keywords

ACTIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYTOCHROME C; HYDROGEN SULFIDE; LACTATE DEHYDROGENASE; MALIC ACID; PHOSPHODIESTERASE; PHOSPHODIESTERASE 2A; PYRUVIC ACID; SUCCINIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR DISTRIBUTION; DIGESTION; ELECTRON TRANSPORT; ENZYME ACTIVITY; HYDROLYSIS; IN VITRO STUDY; LIVER MITOCHONDRION; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; WESTERN BLOTTING;

3-ISOBUTYL-1-METHYLXANTHINE (CID: 3758); 8-BROMO CYCLIC AMP SODIUM SALT (CID: 1913); 9-(2-HYDROXY-3-NONYL)ADENINE (CID: 3206); ADENOSINE 5′-DIPHOSPHATE; ADENOSINE 5′-DIPHOSPHATE (CID: 6022); ADENOSINE 5′-TRIPHOSPHATE; ADENOSINE 5′-TRIPHOSPHATE (CID: 11050836); ADP; ATP; CAMP; CAMP-DEPENDENT PROTEIN KINASE/PROTEIN KINASE A; CARBONYL CYANIDE 4-(TRIFLUOROMETHOXY) PHENYLHYDRAZONE; CARBONYL CYANIDE 4-(TRIFLUOROMETHOXY) PHENYLHYDRAZONE (CID: 3330); CCOX, COMPLEX IV; CYC C; CYTOCHROME C; CYTOCHROME C OXIDASE, MITOCHONDRIAL COMPLEX IV; FCCP; H(2)S; HYDROGEN SULFIDE; HYDROGEN SULFIDE (CID: 402); ISOLATED MITOCHONDRIA; OCR; OXYGEN CONSUMPTION RATE; PDE; PHOSPHODIESTERASE; PKA; RP-ADENOSINE 3′,5′-CYCLIC MONOPHOSPHOROTHIOATE (CID: 16218857); SODIUM HYDROGEN SULFIDE (CID: 28015); SQR; SULFIDE:QUINONE OXIDOREDUCTASE;

ANIMALS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2; ELECTRON TRANSPORT; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROGEN SULFIDE; MALE; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84886728728     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.064     Document Type: Article

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