Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment

Molecular Genetics and Metabolism

Volumn 101, Issue 2-3, 2010, Pages 163-171

  Maclean, Kenneth N ^a   Sikora, Jakub ^b   Kožich, Viktor ^b   Jiang, Hua ^a   Greiner, Lori S ^a   Kraus, Eva ^a   Krijt, Jakub ^b   Crnic, Linda S ^a   Allen, Robert H ^c   Stabler, Sally P ^c   Elleder, Milan ^b   Kraus, Jan P ^a  

^a Children's Hospital Colorado   (United States)

^b Charles University in Prague and General University Hospital in Prague   (Czech Republic)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Betaine; Coagulation; Cystathionine; Cystathionine beta synthase; Cystathionine gamma lyase; Homocysteine; Homocystinuria

Indexed keywords

ACETYLCYSTEINE; BETAINE; CYSTATHIONINE BETA SYNTHASE; GENOMIC DNA; HOMOCYSTEINE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING PARAMETERS; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME DEFICIENCY; FEMALE FERTILITY; GENOTYPE; HEMOSTASIS; HISTOLOGY; HOMOCYSTINURIA; HYPERCOAGULABILITY; INBORN ERROR OF METABOLISM; INCIDENCE; KAPLAN MEIER METHOD; KNOCKOUT MOUSE; LIVER DISEASE; LIVER FIBROSIS; LIVER FUNCTION; MENTAL DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; THROMBOEMBOLISM; TREATMENT FAILURE; TREATMENT RESPONSE;

ACETYLCYSTEINE; ANIMALS; BETAINE; CYSTATHIONINE BETA-SYNTHASE; DISEASE MODELS, ANIMAL; FEMALE; HEMOSTASIS; HOMOCYSTEINE; HOMOCYSTINURIA; LIVER; LIVER CIRRHOSIS; MICE; MICE, KNOCKOUT;

MUS;

EID: 77957241706     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2010.06.007     Document Type: Article

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