Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 291, Issue 2, 2006, Pages

  Ramasamy, S ^a   Singh, S ^b   Taniere, P ^c   Langman, M J S ^a   Eggo, M C ^a,d  

^a Division of Medical Sciences   (United Kingdom)

^b UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^c QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Butyrate; Colorectal cancer; HT 29; Thiosulfate sulfurtransferase

Indexed keywords

3 MERCAPTOPYRUVATE SULFURTRANSFERASE; INTESTINE ENZYME; SULFURTRANSFERASE; THIOSULFATE SULFURTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL LOSS; CELL STRAIN HT29; COLON CANCER; COLORECTAL CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTESTINE CELL; PRIORITY JOURNAL; WESTERN BLOTTING;

CELL DIFFERENTIATION; CELL LINE, TUMOR; COLONIC NEOPLASMS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; HYDROGEN SULFIDE; SUBSTRATE SPECIFICITY; SULFURTRANSFERASES; THIOSULFATE SULFURTRANSFERASE; UP-REGULATION;

EID: 33745778247     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00324.2005     Document Type: Article

References (30)

1. Aminlari M and Gilanpour H. Comparative studies on the distribution of rhodanese in different tissues of domestic animals. Comp Biochem Physiol B 99: 673-677, 1991.
2. Attene-Ramos MS, Wagner ED, Plewa MJ, and Gaskins HR. Evidence that hydrogen sulfide is a genotoxic agent. Mol Cancer Res 4: 9-14, 2006.
3. Birkenkamp-Demtroder K, Christensen LL, Olesen SH, Frederiksen CM, Laiho P, Aaltonen LA, Laurberg S, Sorensen FB, Hagemann R, and Orntoft TF. Gene Expression in Colorectal Cancer. Cancer Res 62: 4352-4363, 2002.
4. Birkenkamp-Demtroder K, Olesen SH, Sorensen FB, Laurberg S, Laiho P, Aaltonen LA, and Orntoft TF. Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut 54: 374-384, 2005.
5. Deplancke B and Gaskins HR. Hydrogen sulfide induces serum-independent cell cycle entry in nontransformed rat intestinal epithelial cells. FASEB J 17: 1310-1312, 2003.
6. Furne J, Springfield J, Koenig T, DeMaster E, and Levitt MD. Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa. Biochem Pharmacol 62: 255-259, 2001.
7. Hinnebusch BF, Meng S, Wu JT, Archer SY, and Hodin RA. The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132: 1012-1017, 2002.
8. Hulin SJ, Singh S, Chapman MA, Allan A, Langman MJ, and Eggo MC. Sulphide-induced energy deficiency in colonic cells is prevented by glucose but not by butyrate. Aliment Pharmacol Ther 16: 325-331, 2002.
9. Jarabak R. 3-Mercaptopyruvate sulfurtransferase. Methods Enzymol 77: 291-297, 1981.
10. Leschelle X, Goubern M, Andriamihaja M, Blottiere HM, Couplan E, Gonzalez-Barroso MD, Petit C, Pagniez A, Chaumontet C, Mignotte B, Bouillaud F, and Blachier F. Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide. Biochim Biophys Acta 1725: 201-212, 2005.
11. Levitt MD, Furne J, Springfield J, Suarez F, and DeMaster E. Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa. J Clin Invest 104: 1107-1114, 1999.
12. Nagahara N, Ito T, and Minami M. Mercaptopyruvate sulfurtransferase as a defense against cyanide toxication: molecular properties and mode of detoxification. Histol Histopathol 14: 1277-1286, 1999.
13. Nagahara N and Nishino T. Role of amino acid residues in the active site of rat liver mercaptopyruvate sulfurtransferase. CDNA cloning, overexpression, and site-directed mutagenesis. J Biol Chem 271: 27395-27401, 1996.
14. Nagahara N, Okazaki T, and Nishino T. Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-directed mutagenesis. J Biol Chem 270: 16230-16235, 1995.
15. Picton R, Eggo MC, Merrill GA, Langman MJ, and Singh S. Mucosal protection against sulphide: importance of the enzyme rhodanese. Gut 50: 201-205, 2002.
16. Prior P, Gyde S, Macartney J, Thompson H, Waterhouse J, and Allan R. Cancer morbidity in ulcerative colitis. Gut 23: 490-497, 1982.
17. Ramsden JD, Cocks HC, Shams M, Nijjar S, Watkinson JC, Sheppard MC, Ahmed A, and Eggo MC. Tie-2 is expressed on thyroid follicular cells, is increased in goiter, and is regulated by thyrotropin through cyclic adenosine 3′,5′-monophosphate. J Clin Endocrinol Metab 86: 2709-2716, 2001.
18. Roediger WE. The colonic epithelium in ulcerative colitis: an energy-deficiency disease? Lancet 2: 712-715, 1980.
19. Roediger WE, Duncan A, Kapaniris O, and Millard S. Reducing sulfur compounds of the colon impair colonocyte nutrition: implications for ulcerative colitis. Gastroenterology 104: 802-809, 1993.
20. Siavoshian S, Segain JP, Kornprobst M, Bonnet C, Cherbut C, Galmiche JP, and Blottiere HM. Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. Gut 46: 507-514, 2000.
21. Singh B, Halestrap AP, and Paraskeva C. Butyrate can act as a stimulator of growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources. Carcinogenesis 18: 1265-1270, 1997.
22. Sobin LHWC. TNM Classification of Malignant Tumours. New York: Wiley, 2002.
23. Sorbo B. Crystalline rhodanese. I. Purification and physicochemical examination. Acta Chem Scand 7: 1129-1136, 1953.
24. Sorbo B. Enzymic transfer of sulfur from mercaptopyruvate to sulfite or sulfinates. Biochim Biophys Acta 24: 324-329, 1957.
25. Suarez F, Furne J, Springfield J, and Levitt M. Insights into human colonic physiology obtained from the study of flatus composition. Am J Physiol Gastrointest Liver Physiol 272: G1028-G1033, 1997.
26. Vachek H and Wood JL. Purification and properties of mercaptopyruvate sulfur transferase of Escherichia coli. Biochim Biophys Acta 258: 133-146, 1972.
27. Velcich A, Palumbo L, Jarry A, Laboisse C, Racevskis J, and Augenlicht L. Patterns of expression of lineage-specific markers during the in vitro-induced differentiation of HT29 colon carcinoma cells. Cell Growth Differ 6: 749-757, 1995.
28. Westley J. Rhodanese. Adv Enzymol Relat Areas Mol Biol 39: 327-368, 1973.
29. Westley J, Adler H, Westley L, and Nishida C. The sulfurtransferases. Fundam Appl Toxicol 3: 377-382, 1983.
30. Wrobel K, Claudio E, Segade F, Ramos S, and Lazo PS. Measurement of cytotoxicity by propidium iodide staining of target cell DNA. Application to the quantification of murine TNF-α. J Immunol Methods 189: 243-249, 1996.